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    Assessment of renal functions with different glomerular filtration rate formulas in children with acute exposure of mercury
    (Walter De Gruyter Gmbh, 2015) Bal, Ceylan; Gungor, Oya Torun; Celik, Huseyin Tugrul; Abusoglu, Sedat; Uguz, Nihal; Tutkun, Engin; Yilmaz, Omer Hinc
    Objective: Our aim was to determine whether cystatin C level has a superiority to creatinine to assess kidney functions in rapid decreases of glomerular filtration rate due to acute mercury exposure in children. Eight different glomerular filtration rate calculation formulas which have been used creatinine and/or cystatin C were also compared. Methods: Serum urea, creatinine and cystatin C values of 39 mercury exposed children were measured. Glomerular filtration rates were calculated by eight different formulas. Patient group was divided into three subgroups according to mercury levels. Results: Cystatin C and mercury levels of the patients were found significantly different from control group (p<0.001). There was not a significant difference in creatinine and urea values between two groups (p=0.913, p=0.236). There was not a significant difference between patient and control groups in GFR calculations which have been used serum creatinine and height or which have been used urea additional to them (p=0.069, p=0.559, p=0.424, p=0.945, respectively), but there was a significant difference between patient and control groups in GFR calculations which have been used cystatin C only or creatinine, urea and height in addition to this (p<0.001, p<0.001, p=0.042, p<0.001, respectively). In sugroup analysis, cystatin C results and the results of three GFR calculations of four GFR calculations which were used cystatin C were found different in control group according to subgroups but there was not a difference between subgroups. Conclusion: Cystatin C level is a better indicator than creatinine to assess kidney functions in rapid decreases of glomerular filtration rate due to acute exposure of mercury. Formulas using cystatin C gave better results than formulas using creatinine and height in estimation of glomerular filtration rate.
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    Impairment of Glucose Tolerance Test During Pregnancy and Serum Assymmetric Dimethylarginine Levels
    (Derman Medical Publ, 2016) Findik, Rahime Bedir; Celik, Huseyin Tugrul; Yilmaz, Fatma Meric; Yilmaz, Hinc; Abusoglu, Sedat
    Aim: Assymetric dimethylarginin (ADMA), an inhibitor of nitric oxide synthase (NOS), has been linked to endothelial dysfunction. Our aim in this study was to compare ADMA and arginine levels in normal glucose tolerance, impaired glucose tolerance and gestational diabetes groups and investigate the effect on baby birth weight. Material and Method: Serum ADMA and arginine levels were investigated in 64 patients whose 50-g glucose loading test was normal (group 1, NGT); 33 patients whose 50-g test result was high and those whose 100-g oral glucose tolerance test (OGTT) was normal, namely, those with impaired glucose tolerance (IGT, group 2); and in 8 patients diagnosed with gestational diabetes mellitus (GDM, group 3). Results: Arginine levels were significantly higher in the IGT group than in the NGT group. ADMA levels were high in the GDM group, but the difference was not statistically significant. There were a statistically significant correlation between arginine and ADMA levels and the ADMA level of those with a diabetes history. No significant relationship was found between ADMA level, arginine and the weight of the infant. Discussions: Although there has not been a clinical status related with nitric oxide deficiency caused by increasing ADMA concentrations, pregnancies with increased body mass indeks (BMI), family history for diabetes and older ages should be carefully monitorized. ADMA tends to increase in patients with IGT and GDM. In addition, blood ADMA and arginine levels do not seem to influence the weight of the infant.
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    Mean platelet volume level in chromium exposed workers
    (Elsevier Ireland Ltd, 2014) Hocaoglu, Asim; Bal, Ceylan; Celik, Huseyin Tugrul; Abusoglu, Sedat; Yilmaz, Hinc; Tutkun, Engin
    [Abstract Not Available]
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    Serum asymmetric dimethylarginine and nitric oxide levels in Turkish patients with acute ischemic stroke
    (Wroclaw Medical Univ, 2019) Ercan, Mujgan; Mungan, Semra; Guzel, Isil; Celik, Huseyin Tugrul; Bal, Ceylan; Abusoglu, Sedat; Akbulut, Deniz
    Background. Nitric oxide synthase (NOS) is present in the brain and cerebral arteries and it enables the synthesis of nitric oxide (NO), which plays a critical role in brain perfusion. Asymmetrical dimethylarginine (ADMA) is an endogenous NOS inhibitor. Objectives. The aim of this study was to evaluate serum ADMA levels, which are an indicator of endothelial dysfunction of the renal functions in patients with acute ischemic stroke, and to determine whether there is a possible correlation between ADMA and NO levels and the L-arginine-to-ADMA ratio. Material and methods. Fifty-two patients (22 male and 30 female; mean age: 75.2 +/- 10.1 years) with a diagnosis of acute ischemic stroke in the first 24 h post-stroke and 48 healthy individuals (controls; 13 male and 35 female; mean age: 60.1 +/- 7.92 years) were included in this study. The risk factors recorded and evaluated were age and gender of the patients, serum lipid levels, serum ADMA levels, nitrate-to-nitrite ratios, l-arginine, l-arginine-to-ADMA ratios, sedimentation rate, C-reactive protein (CRP), urea and creatinine levels, and glomerular filtration ratio (eGFR). Results. The mean serum ADMA level was 0.48 +/- 0.23 mu M for the patients and 0.36 +/- 0.18 mu M for the controls. The mean NO level was 2.78 +/- 0.59 mu M for the patient group and 4.49 +/- 2.84 mu M for the controls. The ADMA levels for the patient group were significantly higher than for the control group (p = 0.011); the NO levels for the patients were significantly lower than for the controls (p < 0.001). The logistic regression method demonstrated that ADMA and NO levels may be independent risk factors for the patient group, and the receiver operating characteristic (ROC) curve analysis showed that both of these variables were discriminative risk factors. Conclusions. An increased serum level of the NOS inhibitor ADMA was found to be a possible independent risk factor for ischemic stroke.
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    The Role of Asymmetric Dimethyl Arginine and Nitric Oxide in Patients with Chronic Pancreatitis
    (Canadian Soc Clinical Investigation, 2015) Cakmak, Muzaffer; Erdamar, Husamettin; Kazanci, Fatmanur; Gok, Sumeyye; Abusoglu, Sedat; Unlu, Ali; Aydin, Safak
    Purpose: Endothelial dysfunction (ED) is a well-known pathological feature in the development of many diseases. The dysfunctional condition includes reduction in nitric oxide (NO) bioavailability. Chronic pancreatitis (CP) is a progressive and irreversible destruction of pancreas, and may lead to varying degrees of endocrine and exocrine dysfunction. NO released from endothelial cells is thought to be involved in the pathogenesis of CP; however, there is no study investigating the relationship between CP and ED. The purpose of this study was to investigate the levels of NO and methylarginines, including AMDMA, in patients with CP. Patients and Methods: A total of 44 patients with CP and 36 healthy volunteers were included in this study. Serum levels of ADMA, SDMA, NMMA, arginine, and citrulline were analyzed by LC-MS/MS and nitric oxide levels were analyzed using ELISA. Results: Serum SDMA levels were higher in patients with CP (0.55 +/- 0.02 mu mol/L vs. 0.47 +/- 0.02 mu mol/L, p=0.041), whereas NMMA levels were lower in patients with CP (0.052 +/- 0.003 mu mol/L vs 0.068 +/- 0.003 mu mol/L, p<0.001). There was a correlation between the C-reactive protein and SDMA levels (r=0.443, p=0.004). Conclusion: Elevated SDMA and reduced NMMA levels may be responsible for the increased pancreatic damage. Circulating SDMA may be a better marker of stage pancreatic detriment with respect to ADMA or NO in subjects with CP. Further research for possible associations among serum SDMA, ADMA, NO and other measures of pancreatitis may be beneficial in order to better understand the pathophysiology of CP and establish more effective treatment options.