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Öğe A Comparative Analysis of Psychiatric Symptoms in Parkinson's Disease Between Tremor-Dominant and Non-Tremor-Dominant Phenotypes(Wolters Kluwer Medknow Publications, 2025) Akan, Mustafa; Ciplak, Sibel; Adiguzel, AhmetBackground:There is currently no study comparing psychiatric symptoms in Parkinson's patients with tremor-dominant (TD) and non-tremor-dominant (NTD) phenotypes. Our research hypothesis suggests that patients with the TD phenotype would have higher levels of anxiety compared to those with the NTD phenotype. Objective:To test this hypothesis and fill the gap in the literature. Methods:The study included 128 patients, 77 in the TD group and 51 in the NTD group. After their neurological evaluation, the same psychiatrist interviewed them, and the Brief Symptom Inventory (BSI) and sociodemographic data form were administered. Results:The TD group had statistically significantly higher scores on the BSI total and anxiety scores (P < 0.001 for both analyses). Linear regression analysis revealed that being in the TD group was an independent risk factor for BSI total and anxiety scores (P < 0.001 for both analyses). Conclusions:The results of our study are noteworthy as they show higher psychiatric symptoms in the TD group, despite previous studies reporting worse prognosis in Parkinson's patients with NTD phenotypes. In addition, the presentation of psychiatric symptoms in Parkinson's disease appears to be linked to how the disease manifests clinically.Öğe A NEW ARTIFICIAL INTELLIGENCE-BASED CLINICAL DECISION SUPPORT SYSTEM FOR DIAGNOSIS OF MAJOR PSYCHIATRIC DISEASES BASED ON VOICE ANALYSIS(Medicinska Naklada Zagreb, 2023) Cansel, Neslihan; Alcin, Ömer Faruk; Yılmaz, Ömer Furkan; Ari, Ali; Akan, Mustafa; Ucuz, İlknurBackground: Speech features are essential components of psychiatric examinations, serving as important markers in the recognition and monitoring of mental illnesses. This study aims to develop a new clinical decision support system based on artificial intelligence, utilizing speech signals to distinguish between bipolar, depressive, anxiety and schizophrenia spectrum disorders. Subjects and methods: A total of 79 patients, who were admitted to the psychiatry clinic between 2020-2021, including 15 with schizophrenia spectrum disorders, 24 with anxiety disorders, 25 with depressive disorders, and 15 with bipolar affective disorder, alongside with 25 healthy individuals were included in the study. The speech signal dataset was created by recording participants’ readings of two texts determined by the Russell emotion model. The number of speech samples was increased by using random sampling in speech signals. The sample audio signals were decomposed into time-frequency coefficients using Wavelet Packet Transform (WPT). Feature extraction was performed using each coefficient obtained from both Mel-Frequency Cepstral Coefficients (MFCC) and Gammatone Cepstral Coefficient (GTCC) methods. The disorder classification was carried out using k-Nearest Neighbor (kNN) and Support Vector Machine (SVM) classifiers. Results: The success rate of the developed model in distinguishing the disorders was 96.943%. While the kNN model exhibited the highest performance in diagnosing bipolar disorder, it performed the least effectively in detecting depressive disorders. Whereas, the SVM model demonstrated close and high performance in detecting anxiety and psychosis, but its performance was low in identifying bipolar disorder. The findings support the utilization of speech analysis for distinguishing major psychiatric disorders. In this regard, the future development of artificial intelligence-based systems has the potential to enhance the psychiatric diagnosis process. © Medicinska naklada – Zagreb, Croatia.Öğe Caregiver burden in caregivers of patients receiving home health care services applying to emergency department of a city hospital: a cross-sectional study(Malatya Turgut Özal Üniversitesi, 2024) Ertek, Engin; Akan, MustafaBackground: Patients receiving home health care services need caregivers who will undertake their care at home in order to meet their needs. In this process, caregivers experience some problems related to their own functionality and face care burden. Although caregiving is associated with physical and psychological distress in studies in the literature, this situation can also be perceived as a reward by the caregiver with the development of positive emotions. In this study, it was aimed to investigate caregiver burden and related factors in caregivers of patients receiving home health care services who applied to the emergency department of a city hospital. The hypothesis of the study is that caregiver burden will be lower in caregivers who provide wound care support (WCS) compared to those who do not. Materials and Methods: The study was conducted in the emergency clinic of a city hospital between 04.04.2024 and 04.08.2024. The study included caregivers of patients who received home health care services and applied to the emergency department, and the Zarit Caregiver Burden (ZCB) scale and sociodemographic data form were applied to the participants. Results: In the study of 120 participants, the mean age of the participants was found to be 44.6±12.3 years and the total score of the ZCB scale was 42.5 (19-77). When analysed in terms of WCS, it was observed that 92 (76.7%) of the caregivers provided WCS. When the caregivers were divided into two groups as providing WCS and not providing WCS, it was found that the group providing WCS had a statistically significantly lower total score on the ZCB scale than the group not providing WCS (pÖğe Emotional Dysregulation and Temperament-Character Traits in Adolescents With Functional Neurological Symptom Disorder (Conversion Disorder)(Lippincott Williams & Wilkins, 2024) Ucuz, Ilknur; Cicek, Ayla Uzun; Celik, Merve Komurcu; Akan, Mustafa; Kesriklioglu, Esma; Gungor, Serdal; Ozcan, Ozlem OzelThe purpose of this study was to evaluate emotion dysregulation and temperament-character traits in adolescents with functional neurological symptom disorder (FNSD). Forty adolescents with FNSD and 40 healthy adolescents were evaluated by a semiconstructed diagnosis interview, Temperament and Character Inventory (TCI), Difficulties in Emotion Regulation Scale (DERS), Regulation of Emotions Questionnaire (REQ), and Children's Somatization Inventory-24 (CSI-24). The external and internal dysfunctional emotion regulation scores of REQ, all subscales of DERS, except the awareness subscale, and CSI-24 scores were significantly higher in FNSD patients compared with healthy controls. There were significant differences between the groups in terms of harm avoidance and reward dependence subscale scores of TCI. Multiple logistic regression analysis showed that the external dysfunctional emotion regulation strategy, somatization, and reward dependence are significant predictors of FNSD. Our results provide evidence that adolescents with FNSD experience emotional dysregulation and that the differential value of some temperament-character traits in the diagnosis of FNSD.Öğe Evaluation of Earthquake Survivors of the February 6 Turkey Earthquakes: The Mediating Role of Hopelessness in the Relationship Between Psychological Resilience and Posttraumatic Embitterment Symptoms(Korean Neuropsychiatric Assoc, 2026) Akan, Mustafa; Unal, Suheyla; Inceoglu, FeyzaObjective Following the February 6 earthquakes, survivors faced intense psychological distress, including feelings of disappointment, perceived injustice, and anger-leading to adverse effects on their well-being. Although earthquakes are not human-induced, the abundance of human errors further exacerbated the situation. These outcomes may have triggered symptoms of Posttraumatic Embitterment Disorder (PTED) among survivors. The present study examined the mediating role of hopelessness in the relationship between this resilience and PTED symptoms among individuals who experienced the February 6 earthquakes. Methods This cross-sectional online study was conducted in Malatya, one of the severely affected regions, between July 20, 2023 and January 20, 2024. Participants completed the PTED Scale, the Psychological Resilience Scale, the Beck Hopelessness Scale, and a sociodemographic form through an online survey. The data obtained were analyzed, and structural equation modeling was performed. Results The final sample included 801 participants (mean age=37.82 +/- 11.03 years), of whom 48.6% (n=389) exhibited PTED symptoms. Hopelessness was found to mediate the relationship between psychological resilience and embitterment. Together, psychological resilience and hopelessness accounted for 43.7% of the variance in embitterment (R2=0.437). Conclusion PTED should be considered among the psychological outcomes of earthquakes. The findings highlight the therapeutic potential of hope-based interventions for PTED and underscore the importance of preventive measures targeting vulnerable populations in disaster-affected regions. Our findings can guide health authorities in structuring post-disaster mental health services and assist in developing health policies in this regard. Psychiatry Investig 2026;23(4):548-555Öğe Investigation of the Relationship between Headache and Anxiety during the Late COVID-19 Pandemic Period: A Prospective Case-Control Study(2022) Adıgüzel, Ahmet; Akan, Mustafa; Çıplak, SibelObjective: The effects of the COVID-19 pandemic on both the physical and psychological well-being of individuals have not yet been clearly understood. Especially during the early period of the pandemic, the most prevalent psychological effects included fear, preoccupation with health, anxiety, and feeling of loneliness caused by a general sense of uncertainty. The incidence of headache was as high as 70% among the mild COVID-19 cases. Findings from the past coronavirus outbreaks indicated that neuropsychiatric symptoms might cause a significant health burden and adversely affect the patients’ quality of life. The present study aimed to investigate the anxiety-related clinical conditions of the patients diagnosed with primary headache, who presented to the neurology polyclinic during the prolonged pandemic period. Methods: The research was designed as a two-center, prospective case-control study. Patients diagnosed with primary headache, who presented to the neurology outpatient clinic, and healthy volunteers without a primary headache diagnosis were included in the study. Data collection tools included the sociodemographic data form, Headache Impact Test, Coronavirus Anxiety Scale Short Form, and COVID-19 Disease Perception Scale. Results: Data collected from a total of 869 participants, including 408 (47%) patients diagnosed with headache and 461 (53%) healthy volunteers, were investigated. The results of the Headache Impact Test-6 suggested a severe effect on quality of life in 187 participants (45.8%) in the headache group and 73 participants (15.8%) in the Control Group (p=0.001). There was coronavirus anxiety in 59 (14.5%) participants with headache and 8 (1.7%) participants in the Control Group (p=0.001). Furthermore, the rate of coronavirus anxiety in participants that had and did not have COVID-19 was 44 (13.7%) and 22 (4.1%), respectively (p=0.001). Conclusion: The study results revealed that patients with headache and COVID-19 presented with a higher rate of coronavirus anxiety than healthy controls and those not diagnosed with COVID-19. Further studies on larger samples are necessary for investigating the long term neuropsychiatric effects of COVID-19 in individuals.Öğe Parkinsonism and progressive atypical psychiatric symptoms in the post-stroke subacute period(Malatya Turgut Özal Üniversitesi, 2022) Çıplak, Sibel; Akan, Mustafa; Aba, MelikeStroke has a significant impact on the psychological and physical health of patients. Approximately 1%–4% of patients, movement disorders develop in the early post-stroke period. While chorea appears within hours of a stroke, post-stroke dystonia and tremor may develop after several months. Depression is generally observed in the post-stroke period; however, reports of atypical psychiatric symptoms, such as psychosis, in the early subacute-stroke period are rare. Herein, we demonstrate the case of a patient in whom parkinsonism symptoms and atypical psychiatric findings were found, which progressed to 3 and 2 weeks, respectively, after ischemic stroke.Öğe SCuopmeprvairsiisoonn woift hsu cbosntatrnocles iuns etersrm usn doefr a jtutdeinc-ial ttiioonn rdeegfiucliatt ihoynp edrifafcictiuvlittiye sd(2024) Akan, Mustafa; Uğur, Kerim; AYAZ, NusretObjective: Substance abuse and addiction are reported to be approximately 2 times more common in individuals diagnosed with Attention Deficit Hyperactivity Disorder (ADHD) compared to the general population. Adults with ADHD have been stated to have difficulties in emotion regulation as well as core symptoms of the disease. In this study, it was aimed to evaluate individuals who applied to a university hospital psychiatry clinic probation clinic in terms of attention deficit hyperactivity disorder and emotion regulation difficulties. The hypothesis of the study is that individuals who apply to the outpatient clinic will have higher ADHD symptoms and emotion regulation difficulties than healthy controls. Method: The research was conducted between 18.06.22-30.10.22. 135 male patients diagnosed with substance use disorder and 141 healthy volunteers without any psychiatric disease were included in the study. Adult ADHD selfreport scale (ASRS), Difficulty in Emotion Regulation Scale Short Form (DERS-16), and sociodemographic data form were administered to the participants. Results: The probation group's ASRS total score, attention deficit and hyperactivity/impulsivity subscale scores were found to be statistically significantly higher than the control group (p=0.004, p=0.005, p=0.007, respectively). Also DERS-16 impulse and nonacceptance subscale scores of the probation group were statistically significantly higher than the control group (p=0.001, p=0.015, respectively). Discussion: ADHD and accompanying emotion regulation difficulties may increase the risk of substance use in adults. Considering these clinical features in individuals applying to the probation outpatient clinic may make therapeutic interventions more effective.Öğe Self-Construal and Conflict Resolution Styles in Relation to Marital Satisfaction and Adjustment: A Structural Equation Model From Türkiye(Sage Publications Inc, 2026) Akan, Mustafa; Unal, Suheyla; Inceoglu, FeyzaThis study investigates how self-construals (autonomy, relatedness, and autonomous-relatedness) and conflict resolution styles predict marital satisfaction and adjustment in a Turkish sample using structural equation modeling (SEM). A total of 1,037 married individuals (68.8% women) participated in the study. Results revealed that self-construals significantly associated with conflict resolution styles, which in turn were associated with marital outcomes. Specifically, autonomous-related self-construal was associated with increased use of constructive conflict strategies and decreased use of destructive or passive strategies (e.g., withdrawal, submission). These patterns were consistent across gender, though effect sizes varied. Notably, passive strategies such as withdrawal (in men) and submission (in women) were significantly negatively associated with marital adjustment and satisfaction. Conversely, constructive conflict resolution styles and autonomous-related self-construal have been found to be positively associated with marital quality. The model accounted for 75.9% of the variance in marital satisfaction for women and 73.2% for men. The findings support the notion that culturally grounded self-construals shape interpersonal behavior in intimate relationships and highlight the adaptive value of autonomous-relatedness in collectivistic-modernizing societies. These results have practical implications for culturally sensitive couple interventions. Future research should explore these dynamics using dyadic and longitudinal data to clarify causal pathways.Öğe Şizofreni Hastalarında Şiddetle İlişkili Faktörler: Retrospektif Bir Çalışma(2023) Akan, Mustafa; Ayaz, Nusret; KARTALCI, ŞÜKRÜAmaç: Şizofreni hastalarının diğer ruhsal bozukluğu olan has- talara göre ya da genel topluma göreşiddete başvurma olasılıkları daha yüksektir. Antisosyal kişilik özelliklerinin şizofrenili hastalarda şiddet için risk faktörü olabilece ği öne sürülmü ştür. Bu ara ştırmanın amacı, şiddet eylemi olan şizofreni hastalarında, şiddet eylemi olmayan şizof- reni hastalarını karşılaştırarak şiddetli ilişkili faktörleri değerlendirmek ve antisosyal ki şilik özelliklerin şiddet eylemlerinde etkisini incele- mektir. Gereç ve Yöntemler: 2016-2017 yılları arasında adli amaçl ı psikiyatri kliniğine getirilen şiddete başvurmuş şizofreni hastaları ve aynı yıl psikotik alevlenmeyle kliniğe getirilen şiddet öyküsü olmayan şizofreni hastaları araştırmaya alınmıştır. Hastaların dosyaları retros- pektif incelenerek, bazı sosyodemografik veriler ve dosyalarda yer alan psikiyatrik ölçek puanlar ı kaydedilmiştir. Belirlenen tarihlerde adli amaçlı kliniğe getirildiği tespit edilen 20 hasta, psikotik alevlenmeyle kliniğe getirilen 20 hasta ile karşılaştırılmıştır. Bulgular: Şiddet eyle- minde bulunan hastaların 16’sı (%80) erkek, 4’ü (%20) kadındı. Şiddet eylemi olmayan grupta hastalar ın 13’ü (%65) erkek, 7’si (%35) ka- dındı. Hastaların yaş ortalaması 33,32±8,65 idi. Her iki grup, antisos- yal ki şilik özellikleri aç ısından kar şılaştırıldığında, aralar ında istatistiksel olarak anlamlı farklılık saptanmamıştır. Şiddet eylemi olan grupta, karşılaştırma grubuna göre istatistiksel olarak anlaml ı şekilde daha yüksek Pozitif Belirtileri Değerlendirme Ölçeği puanı, daha düşük ilaç uyumu bulunmuştur (sırasıyla p=0,01, p=0,02). Sonuç: Şizofreni hastalarında şiddet, antisosyal kişilik özelliklerinden ziyade hastalığın kendi unsurlarıyla ilişkili olabilir. Şizofrenide şiddetle ilişkili risk fak- törlerini belirlemede daha geniş örneklemler ile yapılacak, daha iyi ya- pılandırılmış gelecek çalışmalara ihtiyaç vardır.Öğe The effect of Ramadan fasting on mental health and some hormonal levels in healthy males(Springer, 2023) Akan, Mustafa; Unal, Suheyla; Gonenir Erbay, Lale; Taskapan, Mehmet CagatayBackgroundMillions of Muslims around the world fast during the holy month of Ramadan as a requirement of their religion Islam. Studies have reported varying effects of Ramadan fasting on mental health and various hormones. This study aimed to examine the effects of Ramadan fasting on mental health and plasma Leptin, Ghrelin, Neuropeptide Y (NPY), Growth Hormone levels in healthy individuals, and to evaluate the possible relationship between their hormone values and scale scores. Male healthcare professionals working at a university hospital without any psychiatric disease were included in the study. In the last week before Ramadan and in the first week after Ramadan, participants' blood samples were taken at 8.00 in the morning after 12 h of fasting, taking into account the release pattern and pulsatile release of these hormones in order to measure plasma Leptin, Ghrelin, NPY and Growth Hormone levels. Simultaneously, a sociodemographic data form, the Brief Symptom Inventory (BSI) and the Scale of Dimensions of Interpersonal Relationships were applied to participants.ResultsThe sample of the study included a total of 40 healthcare professionals. Participants' BSI interpersonal sensitivity and phobic anxiety subscales scores and their general severity and positive symptom distress index scores decreased significantly after Ramadan compared to those measured before Ramadan. (p < 0.001, p = 0.020, p = 0.042, p = 0.006 respectively). Also participants' ghrelin levels increased significantly after Ramadan compared to those measured before Ramadan (p < 0.001).ConclusionsThe effects of Ramadan fasting on mental health may be mediated by some psychoneuroendocrine mechanisms. In order to elucidate these mechanisms that mediate the effect of Ramadan fasting on mental health, there is a need for better-structured studies with larger samples and more variables.
