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    Endoscopic Management of Maxillary Sinus Schwannoma
    (Lippincott Williams & Wilkins, 2022) Celik, Turgut; Koca, Cigdem Firat; Aydin, Sukru
    Schwannomas are benign tumors originate from nerve sheath. In this article, the authors aimed to share our experience and review the literature on endonasal endoscopic intervention for a maxillary sinus schwannoma. A 30-year-old Caucasian female patient applying to ophthalmology clinic due to exophthalmos and proptosis in her left eye for the last 6 months. A well-defined mass was detected in left maxillary sinus that was filling and expanding the sinus. Endoscopic biopsy from the patient was reported as ancient schwannoma. The encapsulated mass was completely removed by performing a combined endoscopic medial maxillectomy and Caldwell-Luc procedure under general anesthesia. The authors have been following the patient for 2 years and there was no evidence of recurrence, however, a decrease in the volume of the maxillary sinus occurred, suggesting chronic maxillary atelectasis. In conclusion, schwannoma should be considered in the differential diagnosis of sinonasal masses.
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    Relationship Between Viral Load and Laboratory Values and Radiological Findings in Patients with COVID-19
    (Galenos Publ House, 2022) Altintop Geckil, Aysegul; Benk, Isilay Gokce; Aydin, Sukru; Akcicek, Mehmet
    Introduction: This study investigates the relationship between the viral load calculated from oropharyngeal/nasopharyngeal swabs at diagnosis and the laboratory parameters and radiological findings in patients with Coronavirus disease-2019 (COVID-19). Materials and Methods: Sixty-seven patients who were positive for severe acute respiratory syndrome-coronavirus-2 via quantitative reverse transcription-polymerase chain reaction (qPCR) from their oropharyngeal/nasopharyngeal swabs and admitted to Malatya Turgut Ozal University Hospital were included in the study. Demographic data, laboratory parameters, and the severity of thorax computed tomography findings were recorded. The relationship between the viral load and these data was compared. Results: The mean age of the patients was 63.4 +/- 9.8 years, mean body mass index (BMI) was 28.6 +/- 5.4 kg/m(2), and mean cycle threshold (Ct) values were 21.4 +/- 5.2 cycles. No correlation was found between Ct value and gender, age, and BMI. There was a significant relationship between radiological severity and Ct value, age, and gender. There was a significant correlation between the Ct value and C-reactive protein, leukocyte, neutrophil, lymphocyte, neutrophil-lymphocyte ratio, ferritin, albumin, and calcium levels. In contrast, no significant correlation was found between hemoglobin, hematocrit, thrombocyte, urea, creatinine, total protein, gamma glutamyl transferase, alkaline phosphatase, sodium, potassium, D-dimer, procalcitonin levels, and Ct value. Conclusion: The viral load amount shown by PCR during the early period predicts the condition of the patient's lung in the advanced immunological phase. The Ct value can be an independent factor for evaluating the patient's radiological and biochemical status.
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    The effect of the severity of COVID-19 on the sequelae of the audiovestibular system
    (Sage Publications Inc, 2023) Aydin, Sukru; Koca, Cigdem Firat; Celik, Turgut; Kelles, Mehmet; Yasar, Seyma; Oguzturk, Saadet
    Objectives: The neurotropic and neuroinvasive properties of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) have been described. It remains unknown how SARS-CoV-2 affects the audiovestibular system when it causes mild or severe disease. In this study, the sequelae effect of SARS-CoV-2 on the audiovestibular systems of different patient groups was investigated using objective and subjective test batteries. Methods: In this present study, we evaluated vestibulocochlear functions of patients who previously had Coronavirus Disease-2019 (COVID-19) with pure tone audiometry, ocular vestibular-evoked myogenic potential (o-VEMP), and cervical vestibular-evoked myogenic potential (c-VEMP) tests to identify possible sequelae by comparing them with the control group. Results: We found that the amplitude of p13-n23 was lower in both groups of patients than in the control group (p < 0.001). In the results of the left ear c-VEMP, the amplitude of p13-n23 was statistically different between the outpatient, inpatient, and control groups. The amplitude of p13-n23 was lower in both groups of patients than in the control group (p < 0.001). In the evaluation of the o-VEMP in the left ear, we observed a statistically significant difference in the latency of n10 (p = 0.006) and the amplitude of n10-p15 (p < 0.001) between the groups. The n10 latency was prolonged in both groups of patients compared to the control group and there was no statistically significant difference between groups of patients. Furthermore, the amplitude of n10-p15 was lower in both groups of patients compared to the control group and there were no statistically demonstrable differences between the groups of patients. Conclusions: In conclusion, our results suggest that SARS-CoV-2 may affect the vestibulocochlear system. But we could not find a direct relationship according to the severity of the disease.
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    The investigation of vestibulary system in patients with thyroid dysfunctions
    (2024) koca, çiğdem fırat; keskin, lezan; KELLEŞ, Mehmet; ÇELİK, TURGUT; Aydin, Sukru; YAŞAR, Şeyma
    A relationship has been detected among thyroid dysfunctions and vestibular pathologies. Our aim was to evaluate the vestibular system in cases with thyroid dysfunctions. Totally 71 patients between the ages of 20-50 with thyroid dysfunctions (35 hypothyroidic and 36 hyperthyroidic) and 36 participants with normal thyroid functions were included. Patients were also allocated as two groups based on antibody positivity. Pure tone audiometry and Vestibular Evoked Myogenic Potential tests were performed for all participants. In the left ear there was a numerically significance in the hypothyroids at 4000 and 8000 Hz (p=0.020 and p=0.014). In the right ear p13 and n23 latencies differed among the groups, (p=0.004 and p=0.001). The p13-n23 and n10-p15 amplitudes were decreased in both patient groups (p<0.001) (p=0.015). For the left ear, the p13 an n23 latencies was prolonged in both patient groups (p=0.044) (p=0.002). The p13-n23 amplitude value was distincted numerically significant (p<0.001). The n10-p15 amplitude was longer in the patients (p=0.004). We can not observe a numerically significance among groups according to antibody positivity (p>0.005). Thyroid dysfunctions may lead to subclinical changes on the vestibular system and the saccular and utriculer impairment may be an early indicator of endolymphatic hydrops.