Yazar "Bilge, Yildiz Dallar" seçeneğine göre listele

Listeleniyor 1 - 2 / 2
  • Küçük Resim Yok
    Öğe
    Effects of neonatal sepsis on thrombocyte tests
    (Taylor & Francis Ltd, 2016) Kara, Semra; Emeksiz, Zeynep; Alioglu, Bulent; Bilge, Yildiz Dallar
    Objective: Hemostatic disorders are common complications in sepsis, and coagulation abnormalities occur in almost all the septic patients. Thrombocytes have a key role in the pathogenesis of coagulation abnormalities in sepsis. This study aimed to investigate thrombocyte function disorders as a likely cause of hemorrhagic diathesis in patients with neonatal sepsis.Material and methods: The study included 70 septic newborns (sepsis group) and 59 healthy newborns (control group). Blood samples were collected from the patients within the first 24h of hospitalization. Thrombocyte aggregation and secretion tests were performed by optical aggregometry and lumi-aggregometry, respectively. Collagen (2g/mL), epinephrine (5M), standard (5M) and high (10M) doses of adenosine diphosphate (ADP), standard (1 unit) and high (4 units) doses of thrombin, ristocetin (1.25mg/mL) and arachidonic acid (0.5mM) were used as the agonists.Results: The mean age of the septic newborns was significantly higher than that of the controls (6.7814.47 days versus 1.25 +/- 1.17, p<0.001). There was no difference between the groups regarding gender- and birth-related characteristics. No difference was observed between the groups regarding platelet count (293.37 +/- 144.48x10(9)/L in the sepsis group and 254.22 +/- 65.26x10(9)/L in the control group, p=0.195). Platelet secretion induced by collagen, epinephrine, standard and high (10M) doses of ADP, or arachidonic acid and platelet aggregation induced by collagen, high-dose ADP, arachidonic acid, ristocetin or thrombin (1 unit) were significantly higher in the sepsis group than in the control group.Conclusion: Based on the results, we concluded that large-scale studies with recurrent tests performed in different periods of sepsis are needed.
  • Küçük Resim Yok
    Öğe
    Evaluation of bone metabolism in newborn twins using quantitative ultrasound and biochemical parameters
    (Taylor & Francis Ltd, 2016) Kara, Semra; Guzoglu, Nilufer; Gocer, Emine; Arikan, Fatma Inci; Dilmen, Ugur; Bilge, Yildiz Dallar
    Metabolic bone disease (MBD) is one of the important complications of prematurity. Early and adequate nutritional interventions may reduce the incidence and potential complications of MBD. The present study aimed to evaluate bone metabolism in twins via biochemical parameters and quantitative ultrasound (QUS) and to compare the results between twin pairs. Moreover, twin infants were evaluated in terms of potential risk factors likely to have impact on MBD. Forty-three pairs of twins were included in the study. Serum calcium, phosphorus, magnesium, and alkaline phosphatase concentrations were assessed and bone mineral density was measured using QUS (speed of sound, SOS) at postnatal 30d. Co-twin with the higher birth weight was assigned to Group 1 (n=36) and the other twin was assigned to Group 2 (n=36). Birth weight and head circumference were significantly higher in the infants of Group 1 compared with Group 2. No significant difference was found among the groups in terms of gender, history of resuscitation, length of stay in intensive care unit (ICU) or in the incubator, duration of total parenteral nutrition (TPN), type of nutrition, vitamin D use, biochemical parameters, and the SOS value. The factors likely to affect SOS, including type of pregnancy, maternal drug use, gender of infant, birth weight, head circumference at birth, gestational week, length of stay at the ICU, duration of TPN, type of nutrition, resuscitation, vitamin D use, and levels of calcium, phosphorus, magnesium, and alkaline phosphatase were entered into the model. The phosphorus level and the maternal drug use were found to be the factors that significantly reduced SOS, whereas pregnancy after assisted reproductive techniques was found to be a significant enhancing factor.