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Öğe Autoimmune progesterone dermatitis(Elsevier Taiwan, 2014) Kaygusuz, Ikbal; Gumus, Ilknur Inegol; Sarifakioglu, Evren; Eser, Ayla; Bozkurt, Bulent; Kafali, Hasan[Abstract Not Available]Öğe Brain-derived neurotrophic factor is increased in serum levels of patients with symptomatic dermographism(Termedia Publishing House Ltd, 2017) Erpolat, Seval; Celik, Huseyin Tugrul; Bozkurt, BulentIntroduction: Symptomatic dermographism (SD) is the most common form of physical urticaria. However, the role of neuroimmune mechanisms in SD is unclear. Aim: To investigate circulating levels of brain-derived neurotrophic factor (BDNF) in symptomatic dermographism. Material and methods: Thirty-two patients suffering from SD and 33 healthy subjects were included in the study. Serum BDNF levels were determined by a human enzyme-linked immunoassay (ELISA) kit. The serum C-reactive protein concentration and eosinophil counts in peripheral blood were evaluated. Results: The BDNF serum levels were detectable in both SD patients and healthy controls. The BDNF serum levels were significantly higher in patients with SD compared with healthy controls (p = 0.004). There was a positive but weak correlation between serum BDNF and CRP levels; it was not statistically significant (r = 0.211, p = 0.255). There was also a positive but weak correlation between serum BDNF and eosinophil counts; it was not statistically significant (r = 0.271, p = 0.141). Conclusions: The present study shows that BDNF is increased in the serum levels of patients with SD, suggesting a role for BDNF in the pathophysiology of this disorder.Öğe Effects of additional manual therapy over inspiratory muscle training in patients with chronic obstructive pulmonary disease: A randomized controlled trial(European Respiratory Soc Journals Ltd, 2015) Cirak, Yasemin; Yelvar, Gul Deniz Yilmaz; Demir, Yasemin Parlak; Dalkilinc, Murat; Kizilirmak, Deniz; Bozkurt, Bulent[Abstract Not Available]Öğe Immediate effect of manual therapy on respiratory functions and inspiratory muscle strength in patients with COPD(Dove Medical Press Ltd, 2016) Yelvar, Gul Deniz Yilmaz; Cirak, Yasemin; Demir, Yasemin Parlak; Dalkilinc, Murat; Bozkurt, BulentObjective: The objective of this study was to investigate the immediate effect of manual therapy (MT) on respiratory functions and inspiratory muscle strength in patients with COPD. Participants and methods: Thirty patients with severe COPD (eight females and 22 males; mean age 62.4 +/- 6.8 years) referred to pulmonary physiotherapy were included in this study. The patients participated in a single session of MT to measure the short-term effects. The lung function was measured using a portable spirometer. An electronic pressure transducer was used to measure respiratory muscle strength. Heart rate, breathing frequency, and oxygen saturation were measured with a pulse oximeter. For fatigue and dyspnea perception, the modified Borg rating of perceived exertion scale was used. All measurements were taken before and immediately after the first MT session. The ease-of-breathing visual analog scale was used for rating patients' symptoms subjectively during the MT session. Results: There was a significant improvement in the forced expiratory volume in the first second, forced vital capacity, and vital capacity values (P < 0.05). The maximal inspiratory pressure and maximal expiratory pressure values increased significantly after MT, compared to the pre-MT session (P < 0.05). There was a significant decrease in heart rate, respiratory rate (P < 0.05), and dyspnea and fatigue perception (P < 0.05). Conclusion: A single MT session immediately improved pulmonary function, inspiratory muscle strength, and oxygen saturation and reduced dyspnea, fatigue, and heart and respiratory rates in patients with severe COPD. MT should be added to pulmonary rehabilitation treatment as a new alternative that is fast acting and motivating in patients with COPD.Öğe Immediate effects of manual therapy in patients with chronic obstructive pulmonary disease(European Respiratory Soc Journals Ltd, 2015) Yelvar, Gul Deniz Yilmaz; Cirak, Yasemin; Demir, Yasemin Parlak; Dalkilinc, Murat; Kizilirmak, Deniz; Bozkurt, Bulent[Abstract Not Available]Öğe Increased Exhaled 8-Isoprostane and Interleukin-6 in Patients with Helicobacter pylori Infection(Wiley-Blackwell, 2016) Yildirim, Zeki; Bozkurt, Bulent; Ozol, Duygu; Armutcu, Ferah; Akgedik, Recep; Karamanli, Harun; Kizilirmak, DenizBackgroundHelicobacter pylori (H. pylori) infection triggers both local inflammation, usually in gastric mucosa, and chronic systemic inflammation. It is assumed that this local and systemic inflammation is caused by extracellular products excreted by H. pylori. The aim of this study was to investigate the possible association between H. pylori infection and a local inflammatory response in the airway by using exhaled breath condensate technique. Materials and MethodsThis study includes 41 H. pylori seropositive patients who have gastric symptoms and 27 healthy control subjects. Pulmonary function tests (PFT), chest X ray, and physical examination were performed in all patients and interleukin-6 (IL-6), 8-isoprostane and nitrotyrosine levels were measured in exhaled breath condensate. ResultsLevels of IL-6 and 8-isoprostane in exhaled breath condensate (EBC) were significantly higher in H. pylori positive patients than control subjects (p < 0.05). Nitrotyrosine levels were also higher in H. pylori positive patients but the difference was not statistically significant. Both groups had similar leukocyte counts, C-reactive protein (CRP) levels and PFT parameters. ConclusionH. pylori infection causes an asymptomatic airway inflammation which can be detected by exhaled breath condensate. The clinical importance of this inflammation remains unclear.Öğe Polysomnographic findings in persistent allergic rhinitis(Springer Heidelberg, 2017) Bozkurt, Bulent; Ugur, K. Serife; Karamanli, Harun; Kucuker, Fatma; Ozol, DuyguPersistent allergic rhinitis (PAR) is characterized by a chronic, eosinophilic inflammation with nasal congestion and rhinorrhea. Nasal congestion can constitute to sleep-disordered breathing problems that range from simple snoring to obstructive sleep apnea syndrome (OSAS). The purpose of this study was to investigate the effect of PAR on sleep quality and severity of OSAS. The study included 150 patients presenting with typical symptoms of sleep apnea. Fifty-five patients were diagnosed as PAR (group-1) and were compared with age and body mass index matched 95 individuals (group-2) without any nasal disease. Skin prick tests and polysomnography were performed in all patients. There were no differences between groups for polysomnographic findings including sleep architecture, arousal and respiratory index, and mean and minimal oxygen saturations. Simple snoring was determined in 41.8 % allergic and 32.6 % non-allergic patients. Mild OSAS was determined in 32.7 % allergic and 29.4 % non-allergic patients. Moderate OSAS was determined in 9 % allergic and 17.8 % non-allergic patients. Severe OSAS was determined in 16.3 % allergic and 20 % non-allergic patients. Their entire Epworth sleepiness scale index was also found similar. Our data pointed out that in patients with sleep-related breathing disorders symptoms, presence of PAR does not affect polysomnographic parameters compared with other patients without any nasal inflammation. Besides, prevalence of OSAS was similar between groups.Öğe Relation of ghrelin, obestatin levels and ghrelin/ obestatin ratio with asthma(European Respiratory Soc Journals Ltd, 2015) Kizilirmak, Deniz; Bozkurt, Bulent[Abstract Not Available]Öğe Relation of ghrelin, obestatin levels and ghrelin/obestatin ratio with sleep quality(European Respiratory Soc Journals Ltd, 2015) Kizilirmak, Deniz; Bozkurt, Bulent[Abstract Not Available]Öğe Relation of hemogram parameters with asthma(European Respiratory Soc Journals Ltd, 2015) Bozkurt, Bulent; Kizilirmak, Deniz[Abstract Not Available]Öğe What is the most reliable marker in the differential diagnosis of pulmonary embolism and community-acquired pneumonia?(Lippincott Williams & Wilkins, 2016) Ates, Hale; Ates, Ihsan; Bozkurt, Bulent; Celik, Huseyin Tugrul; Ozol, Duygu; Yildirim, ZekiBecause of similar clinical manifestations and laboratory findings, differential diagnosis of pulmonary embolism and community-acquired pneumonia (CAP) is generally difficult. Therefore, this study was conducted to find good markers for the easy, cheap, and fast differential diagnosis of pulmonary embolism and CAP. Thirty-four patients diagnosed with pulmonary embolism and 38 patients with CAP who were admitted to either emergency department or chest diseases outpatient clinic were included in this study. On admission and third day, complete blood count, C-reactive protein (CRP), erythrocyte sedimentation rate, procalcitonin (PCT), and D-dimer levels of each patient were measured. Neutrophil-to-lymphocyte ratio (NLR) was calculated using the formula NLR = neutrophil count/lymphocyte count. NLR/D-dimer and PCT/D-dimer ratios were also calculated. First day neutrophil count (P = 0.005), NLR (P = 0.002), CRP (P < 0.001), erythrocyte sedimentation rate (P < 0.001), PCT (P < 0.001), NLR/D-dimer (P < 0.001), and PCT/D-dimer (P < 0.001) levels were higher in patients with CAP compared with patients with pulmonary embolism. In stepwise logistic regression analysis done with all the parameters used for the differential diagnosis of pulmonary embolism and CAP, CRP, PCT/D-dimer, and NLR/D-dimer were found to be independent predictive factors for the presence of CAP. Among these factors, NLR/D-dimer ratio was found to be the most sensitive (97.4%) to have the highest negative predictive value 96.7% and to be the most accurate (area under curve = 0.921) (91.7%) parameter for the differential diagnosis of pulmonary embolism and CAP. In this study, NLR/D-dimer ratio was found to be more sensitive and more selective with negative predictive value and area under curve for the differential diagnosis of pulmonary embolism and CAP compared with other laboratory tests.
