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    Drug-drug interactions in the risky population: elderly, urological patients admitted to the intensive care unit
    (Yüzüncü Yıl Üniversitesi, 2021) Buğday, Muhammet Serdar; Öksüz, Ersoy
    Drug-drug interactions are a common health problem. They cause more serious side effects and are more common in patients with multiple diseases, especially in the elderly. It was aimed herein to examine the frequency of drug -drug interactions in elderly patients treated in the intensive care unit due to urological diseases. This retrospective study was performed on hospital ized patients over the age of 85 years who had urologic diseases and were treated in the intensive care unit. Drug-drug interactions were evaluated using the Rx mediapharma and Lexi interact programs. A total of 91 different medications were administered to 100 patients. Of the patients, 87 had drug-drug interactions and the total number of drug-drug interactions was 550. When all of the interactions were examined, it was observed that drug - drug interactions were most often to cause side effects on the cardiovascular system, such as arrhythmia, hypotension, or hypertension (40%). The drugs that were most involved in drug-drug interactions were furosemide (n: 87), enoxaparin sodium (n: 74), and acetyl salicylic acid (n: 45). The results of the study showed that drug-drug interactions were seen quite frequently in elderly patients hospitalized due to primary urological diseases in the intensive care unit. The most common adverse drug reactions in these patients were bleeding, changes in the therapeutic levels of drugs, and hyperkalemia.
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    Evaluation of post-transplant complications, patient and graft survival in patients with autosomal dominant polycystic kidney disease after renal transplantation; A single center experience
    (2021-08-17) Buğday, Çiğdem; Buğday, Muhammet Serdar; Öksüz, Ersoy; Türkmen, Aydın
    AbstractAim: Autosomal dominant polycystic kidney disease (ADPKD) is systemic, progressive hereditary disease, characterized by cyst formation in multiple organs. Patients with ADPKD mostly develop end stage renal disease (ESRD) and require renal replacement therapy, preferably renal transplantation (RT). In this study, we aimed to compare the post-RT complications, patient and graft survivals in patients with ADPKD and other etiologies of ESRD. Materials and Methods: We retrospectively evaluated patients’ baseline characteristics, post-RT complications, patient and graft survival in patients with ESRD underwent renal transplantation due to ADPKD and other etiologies. We included 28 patients in ADPKD and 28 patients in the control group. Results: The mean survival time was 224.83 ± 7.53 months in all patients. During follow-up period 1 patient died in both groups and 10 years patients and graft survivals were similar for both groups. The graft survival, acute and chronic rejections and glomerular filtration rate levels were similar in both groups end of the first year of RT but total cholesterol and glucose levels were significantly higher in the ADPKD group. Moreover, developing of ischemic heart disease was significantly higher in ADPKD (32% vs 0%, p=0.002), the other complication rates were similar in both. Conclusion: As a comparesion to patients with ESRD underwent RT due to ADPKD and different etiologies, both groups have similar patient and graft survival rates. Patients with ADPKD after transplantation may have a higher incidence of ischemic heart disease.