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    A Cross-Sectional Study on the Relationship between the HEART Score and the Severity of CAD using the SYNTAX Score in Patients with NSTEMI Admitted to the Emergency Department: A Study from Turkey
    (Wolters Kluwer Medknow Publications, 2025) Pepele, M. S.; Aktas, I; Demiroz, O.; Derya, S.; Yildirim, E.; Bilen, M. N.; Demir, B.
    Background:The HEART score is a risk stratification tool for acute chest pain, evaluating history, ECG, age, risk factors, and troponin. The SYNTAX (synergy between percutaneous coronary intervention with TAXUS and cardiac surgery) score assesses the extent and complexity of coronary artery disease (CAD) and is widely used in patients undergoing coronary interventions.Aim:To determine the relationship between the HEART and SYNTAX scores in patients with non-ST elevation myocardial infarction (NSTEMI).Method:A total of 222 NSTEMI patients who underwent coronary angiography were included. The HEART score was calculated at admission, and all patients underwent angiography within 12 hours. SYNTAX was used to evaluate CAD severity. Patients were divided into two groups based on SYNTAX scores. Comparisons were made according to demographic data, laboratory findings, and risk factors. Variables associated with high SYNTAX scores were identified. A P value of < 0.05 was considered statistically significant.Results:The mean age was 63.67 +/- 11.89 years, and 74.77% of the patients were male. Patients with high SYNTAX scores had significantly higher HEART scores and more frequent diabetes and hypertension. High HEART score (OR: 3.09; 95% confidence intervals [CI]: 2.06-4.63; P < 0.001) and diabetes mellitus (OR: 4.57; 95% CI: 1.44-14.47; P = 0.010) were independently associated with high SYNTAX scores. A HEART score >7.5 predicted high SYNTAX scores with 82.1% sensitivity and 84.3% specificity (area under curve [AUC]: 0.892; P < 0.001). A strong positive correlation was found between HEART and SYNTAX scores (P < 0.001, R-2 =0.672).Conclusion:The HEART score was significantly associated with the severity and complexity of CAD in patients with NSTEMI.
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    Investigation of Electrocardiographic Changes Caused by Antepileptic Drugs in Epilepsy Patients
    (Wolters Kluwer Medknow Publications, 2024) Demir, B.; Şahin, L.
    Background: One of the metabolic effects of antiepileptic drugs (AEDs) is cardiac changes. Aim: In our study, to investigate the cardiac effects of AED use; We looked at electrocardiography (ECG) samples performed on patients. By looking at ECG variables, we tried to determine their relationship with epileptic seizure types and antiepileptic drugs. Methods: This prospective study was completed with a total of 50 epilepsy patients whose ECGs were recorded after exclusion criteria. The number of years the patients had epilepsy, the frequency of seizures, the duration of seizures, and the AEDs they used were recorded. Standard 12-lead ECG was applied to the patients, and QT intervals, Tp-e interval, Tp-e/QT ratio, and Tp-e/QTd ratio were measured. Results: Patients most commonly use levatiracetam, valproic acid (VPA), carbamazepine, and lamotrigine, respectively. The median seizure time of the patients was 120 seconds. There was no difference regarding ECG parameters among seizure types. Among the AED groups, Tp-e interval (P = 0.028), Tp-e/QT (P = 0.007), and Tp-e/QTd (P = 0.001) values were lower in those receiving lamotrigine. Conclusion: It was determined that there were differences in cardiac repolarization parameters between AEDs. Lamotrigine had the highest confidence interval due to its low effect on the ECG and low potential to cause arrhythmia. © 2025 Nigerian Journal of Clinical Practice.