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Öğe Clinical significance of ADAMTS1, ADAMTS5, ADAMTS9 aggrecanases and IL-17A, IL-23, IL-33 cytokines in polycystic ovary syndrome(Springer, 2016) Karakose, M.; Demircan, K.; Tutal, E.; Demirci, T.; Arslan, M. S.; Sahin, M.; Celik, H. T.Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders among women of reproductive age. A disintegrin and metalloproteinase with thrombospondin-like motifs (ADAMTS) are involved in inflammation and fertility. The aim of this investigation was to evaluate the serum levels of ADAMTS1, ADAMTS5, ADAMTS9, IL-17, IL-23, IL-33 and to find out the relationship between these inflammatory cytokines and ADAMTSs in PCOS patients. A case-control study was performed in a training and research hospital. Eighty patients with PCOS and seventy-eight healthy female volunteers were recruited in the present study. Serum ADAMTS and IL levels were determined by a human enzyme-linked immunoassay (ELISA) in all subjects. The IL-17A, IL-23 and IL-33 levels were significantly higher in the PCOS patients compared to the controls (p < 0.05). We could not find significant difference between the groups in terms of ADAMTS1, ADAMTS5 and ADAMTS9 levels. IL-17A had positive correlations with LDL cholesterol and IL-33 and negative correlations with ADAMTS1, ADAMTS5, and ADAMTS9. IL-33 had positive correlation with LDL cholesterol and IL-17A. In ROC curve analysis, PCOS can be predicted by the use of IL-17A, IL-23 and IL-33 which at a cut-off value of 8.37 pg/mL (44 % sensitivity, 83 % specificity), 26.75 pg/mL (36 % sensitivity, 64 % specificity) and 14.28 pg/mL (83 % sensitivity, 39 % specificity), respectively. The results of the study might suggest that ADAMTS and IL molecules have a role in the pathogenesis of the PCOS. Further efforts are needed to establish causality for ADAMTS-IL axis.Öğe Differentially regulated ADAMTS1, 8, and 18 in gastric adenocarcinoma(Comenius Univ, 2017) Kilic, M. O.; Aynekin, B.; Kara, A.; Icen, D.; Demircan, K.OBJECTIVE: The aim is to investigate the expression status of ADAMTS1,8, and 18 proteases in gastric cancer (GC) and lymphatic metastasis. BACKGROUND: A disintegrin and metalloprotease with thrombospondin motifs (ADAMTS) is a new protease family, and has important biological functions such as hemostasis, extracellular matrix remodeling and regulation of angiogenesis. METHODS: The immunostaining status of ADAMTS1,8, and 18 were investigated in formalin-fixed paraffin-embedded samples of 25 patients who underwent curative resection for GC. RESULTS: The immune reactivity scores (IRS) of ADAMTS1, 8, and 18 were significantly higher in the cancerous gastric tissue in comparison to non-cancerous gastric tissue (p < 0.001). In addition, IRS scores of these three ADAMTS proteases were higher in the metastatic lymph nodes compared with healthy lymph nodes (p < 0.001). The expression status of the three ADAMTSs in cancerous gastric tissue was correlated with stage of tumor. Additionally, ADAMTS1 expression and ADAMTS8 expression in cancerous gastric tissue were found to correlate with grade and tumor size, respectively. CONCLUSION: This study showed that ADAMTS1, 8, and 18 are highly expressed in GC and its nodal metastases, suggesting important roles of these proteases in carcinogenesis and lymphatic metastasis. The findings from the present study indicate that these proteases may be promising candidates for novel and alternative treatments in GC (Tab. 3, Fig. 3, Ref. 27). Text in PDF www.elis.sk.Öğe Effect of YC-1 on the expression of matrix metalloproteinase 9 in single-dose pentylenetetrazol-induced epileptic seizures(Wiley-Blackwell, 2014) Gurol, G.; Arkan, S.; Demircan, K.; Utkan, T.; Ates, N.[Abstract Not Available]Öğe Evaluation of the expression of ADAMTS-3,-4 and-15 genes in parotid and submandibular salivary glands after RAI therapy(Springer, 2015) Sadic, M.; Atilgan, H. I.; Halacli, S. O.; Demircan, K.; Korkmaz, M.[Abstract Not Available]Öğe IL-17F GENE POLYMORPHISM CORRELATED WITH LONGER DISEASE DURATION OF RHEUMATOID ARTHRITIS PATIENTS(Bmj Publishing Group, 2014) Demircan, K.; Yasar, Z. S.; Yuksel, S.; Hasgul, R.; Cakirbay, H.; Cemeroglu, O.; Yanik, B.[Abstract Not Available]Öğe IL-33 stimulation down-regulated ADAMTS15 gene and protein in U118 glioblastoma cells(Wiley-Blackwell, 2016) Bayram, N. A.; Guven, K. N.; Ilhan, A.; Demircan, K.[Abstract Not Available]Öğe Retinoic acid metabolite (acitretin) showed developmental stage-associated differences of ADAMTS4 in rat fetuses(Wiley-Blackwell, 2016) Toktas, M.; Tugtag, B.; Bayram, N. A.; Tagil, S. M.; Deligonul, E.; Songur, A.; Demircan, K.[Abstract Not Available]Öğe Role of ADAMTS1 and ADAMTS5 in male infertility(Wiley, 2016) Aydos, S. E.; Yukselten, Y.; Sunguroglu, A.; Demircan, K.; Aydos, K.The aim of this study was to investigate the relationship of infertility with metalloproteinases ADAMTS1 and ADAMTS5, which are known to be responsible for the degradation of extracellular matrix (ECM) proteins associated with many diseases. ECM is the noncellular component that provides structural and biochemical support to the surrounding cells required for tissue morphogenesis, differentiation and homoeostasis. Sixty infertile individuals and 10 healthy semen donors were included in this study. The infertile individuals were classified as normozoospermia (NS; n = 20), oligozoospermia (OS; n = 20), azoospermia (AS; n = 20) groups. ADAMTS1 and ADAMTS5 protein levels in semen were analysed by Western blot. ADAMTS1 protein level was 3.0-, 3.3- and 1.6-fold lower in the OS, AS and NS groups, respectively, than in the control group (P < 0.001). ADAMTS5 protein level was 3.2-, 2.7- and 1.4-fold lower in the OS, AS and NS groups, respectively, than in the control group (P < 0.001). Sperm count and sperm motility showed a negative correlation with the levels of ADAMTS1 and ADAMTS5 protein expression: r = -0.477, r = -0.470; and r = -0.332, r = -0.275 respectively (P < 0.001). In conclusion, ADAMTS1 and ADAMTS5 protein expressions in semen are significantly related with sperm production. It is very important to understand molecular function and organisation of ADAMTSs which will be significant in enlightening the process of spermatogenesis in male infertility.Öğe Role of ADAMTS2 and ADAMTS5 Genes in Radioiodine Induced Damage to the Salivary Glands of Rats: Genetic, Immunohistochemical and Histopathological Evaluations(Springer, 2016) Sadic, M.; Demirel, K.; Halacli, S. O.; Karakok, E.; Koca, G.; Ekinci, O.; Demircan, K.[Abstract Not Available]Öğe The role of ADAMTS-12 gene on the pathogenesis of radioiodine-induced salivary gland damage(Springer, 2015) Sadic, M.; Korkmaz, M.; Gultekin, S. S.; Demircan, K.[Abstract Not Available]Öğe Tie2/TEK: a potential biomarker for targeting glioblastoma stem cells(Wiley-Blackwell, 2016) Yukselten, Y.; Bal, M. G.; Ozkanca, S.; Yildiz, D. Akcora; Demircan, K.; Ugur, H. C.; Sunguroglu, A.[Abstract Not Available]
