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    EFFECTS OF HYDROXYCHLOROQUINE PLUS FAVIPIRAVIR TREATMENT ON THE CLINICAL COURSE AND BIOMARKERS IN HOSPITALIZED COVID-19 PATIENTS WITH PNEUMONIA
    (Sestre Milosrdnice Univ Hospital, 2022) Delen, Leman Acun; Gok, Abdullah; Kasapoglu, Umut Sabri; Cagasar, Ozlem; Gok, Zarife; Berber, Nurcan; Derya, Serdar
    Background: The novel coronavirus disease 2019 (COVID-19) has a broad spectrum of clin-ical manifestations, the most common serious clinical manifestation of the coronavirus infection being pneumo-nia. Unfortunately, the optimal treatment approach is still uncertain. However, many studies have been conducted on the effectiveness of several medications in the treatment of COVID-19 infection. The aim of this study was to evaluate the effectiveness of the hydroxychloroquine (HCQ) + favipiravir (FAV) treatment regimen and HCQ alone by comparing the patient's clinical response and laboratory results on the fifth day of treatment in patients hospitalized due to COVID-19 infection.Patients and methods: This retrospective cohort study was conducted in Malatya Training and Research Hospital between March 2020 and July 2020. The study included 69 patients with confirmed COVID-19 with pneumonia. The patients were divided into 2 groups, those receiving HCQ alone and those receiving the HCQ + FAV combination.Results: A total of 69 patients were included in the study, and the mean age was 60.09 +/- 15.56 years. A statisti-cally significant decrease was observed in C-reactive protein (CRP) levels, at the end of the fifth day, in patients who received HCQ + FAV treatment (p=0.002), whereas there was no decrease in CRP levels in patients who received HCQ treatment alone. In addition, an increase in lymphocyte count and a better fever response was observed at the end of the fifth day in patients who received HCQ + FAV (p=0.008). However, there was no statistical difference between both treatment regimens in terms of hospital stay and treatment results (p=0.008, p=0.744, p=0.517).Conclusion: Although the combination of HCQ + FAV treatment was observed to be effective on CRP levels and fever response in patients with COVID-19 pneumonia, there was no difference in terms of hospital stay and discharge.
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    Investigation with Structural Equation Model of the Relationship between Covid-19 Phobia and Secondary Traumatic Stress Level in 112 Emergency Service Personnel
    (İstanbul Teknik Üniversitesi, 2021) Derya, Serdar; Tetik, Bora; Delen, Leman Acun
    [Abstract Not Available]
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    Nicotine addiction in pre-hospital emergency care workers in Turkey: a cross-sectional study
    (Taylor & Francis Inc, 2024) Karakas, Nese; citlik Saritas, Seyhan; Bentli, Recep; Derya, Serdar; Kartal, Mert
    ObjectiveThis study aims to determine the smoking prevalence and nicotine addiction in pre-hospital emergency care workers.MethodsThe study, conducted between March-April 2022 with the participation of 318 pre-hospital care workers, is cross-sectional. To determine the participants' nicotine addiction levels, the participants the Fagerstrom Nicotine Addiction Test (FNAT) was used. For statistical analyses, correlation, chi-square, student's t-test, and analysis of variance (ANOVA) were used. The statistical significance level was accepted as p < .05.ResultsWhile 53.0% Of The Study Group Used To Smoke, 9.1% Thought That Smoking Was Not harmful to health. The mean FNAT score of the smoking group was 5.04 +/- 2.92. Men's FNAT scores (p < .05) were higher for those over the age of 40 than for those under 40 than women (p < .05). In the comparison made according to the participants' occupations, the most smoking group was physicians (p < .05). The group with the highest addiction score among smokers was nurses (p < .05). A positive correlation was found between the years of employment in the sector and the FNAT scores of smokers (r = 0.146, p < .05).ConclusionPre-hospital emergency care workers had a much higher smoking prevalence and nicotine addiction than the medical staff in other units.