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    Evaluation of Superoxide Dismutase and Glutathione Peroxidase Enzyme Polymorphisms in Familial Mediterranean Fever Patients
    (Modestum Ltd, 2015) Akbas, Ali; Ozyurt, Huseyin; Sahin, Semsettin; Benli, Ismail; Saylan, Oguzhan; Aydogan, Leyla; Ekici, Fatih
    Familial Mediterranean Fever (FMF) is a fairly common inflammatory disease in communities with mediterranean origin. It is characterized with autosomal recessive, recurrent short-term episodes of fever, peritoneal, pleural, synovial membrane involvement and skin lesions. The aim of the present study was to investigate possible associations between FMF and Ala-9Val polymorphism of MnSOD and Pro198Leu polymorphism of GPx1. The study included 129 FMF patients who has mutations (E148Q, P369S, F479L, M680I(G/C), M680I(G/A), I692del, M694V, M694I, K695R, V726A, A744S, R761H) in the heterozygous or homozygous form and 95 healthy subjects. To identify MnSOD Ala-9Val and GPx1 Pro198Leu SNPs, genotyping was performed using PCR amplification, and polymorphisms were detected with hybridization probes labeled with fluorescent dyes. Genotype and allele frequencies of Ala-9Val polymorphism of MnSOD and Pro198Leu polymorphism of GPx1 were detected. The MnSOD Val allele frequency is 132 (51.16%) in the FMF and 115 (60.52%) in the control group (p<0.05). The GPx1 Leu allele is 83 (32.17%) in the FMF and 61 (32.11%) in the control group (p=0.988). No significant differences were found between genotype frequencies of GPx1 and MnSOD polymorphisms. According to our findings MnSOD Val allele may be a genetic factor involved in the pathogenesis of FMF. The fact that there are only few studies in literature, we need more patients, other enzyme levels and works about polymorphism to support our study.
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    The Effect of Varying Doses of Intravenous Paracetamol on the Electrical Activity of the Brain in Penicillin-Induced Status Epilepticus in Rats
    (Kare Publ, 2015) Mumcuoglu, Ibrahim; Kurt, Semiha; Aydin, Duygu; Ekici, Fatih; Kasap, Zeynep; Solmaz, Volkan; Aygun, Hatice
    Objectives: Paracetamol is a widely used analgesic and antipyretic agent. It has been reported that N-arachidonoyl-phenolamine, the active metabolite of paracetamol, reduces epilepsy by activating the endocannabinoid system in some models of experimental epilepsy. Diazepam is a benzodiazepine well known to have anticonvulsant effects. The aim of the present study was to investigate the effects of different doses of paracetamol on penicillin-induced epileptiform activity (PIEA) in rats. Methods: Rats anesthetized with urethane (1.25 g/ kg, intraperitoneal) were placed in a stereotaxic frame. Body temperatures were maintained at 37 degrees C by a heating blanket. An epileptic focus was produced by 500 IU Penicillin G (PGP) injection into the soma-motor cortex using a hole drilled into the cranium. Paracetamol (100, 150 and 300 mg/ kg, respectively) and diazepam (5 mg/ kg) were administered thirty minutes after PGP injection, and their effects on the epileptiform activity were examined comparatively. Electrocorticographic activity was monitored for two hours. Results: Intracortical injection of PGP (500 units) induced epileptiform activity in all groups of rats. Diazepam caused a statistical significant decrease in the epileptiform activity in the 40th minute after PGP injection. Paracetamol (100 mg/ kg) application did not influence the PIEA (p> 0.05). However, 150 and 300 mg/ kg IV paracetamol had a statistically significant effect on the antiepileptic activity (p< 0.001). Conclusion: The results of the present study indicated that 150 and 300 mg/ kg doses of paracetamol had an effect on PIEA. Further studies are needed to understand the reasons for this effect.
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    The effects of agomelatine and melatonin on ECoG activity of absence epilepsy model in WAG/Rij rats
    (Tubitak Scientific & Technological Research Council Turkey, 2015) Aygun, Hatice; Aydin, Duygu; Inanir, Sema; Ekici, Fatih; Ayyildiz, Mustafa; Agar, Erdal
    The aim of this study was to evaluate the effect of the melatonergic M1 and M2 receptor agonist and serotonergic 5-HT2C receptor antagonist agomelatine on the spike wave discharges (SWDs) seen in electrocorticographic (ECoG) recordings of WAG/Rij rats with absence epilepsy. Twenty-one WAG/Rij male rats were used in this study. Tripolar electrodes were placed on skulls and control ECoG activities were recorded. Experimental groups received normal saline (Group I: 1 mL, intraperitoneally (i.p)), agomelatine (Group II: 40 mg/kg, i.p), and melatonin (Group III: 40 mg/kg, i.p) injections for 7 days. Following this period, 2-h ECoG recordings were repeated. The number of SWDs and their durations were calculated. The total number and duration of SWDs decreased in both the agomelatine and melatonin groups. The systemic administration of agomelatine and melatonin attenuated the genetic absence epilepsy seizures in WAG/Rij rats. The repressive effect of agomelatine on the absence seizures was similar to that of the melatonin used in this study.