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    Endothelin-1 and Nitric Oxide levels in exudative age-related macular degeneration
    (Wolters Kluwer Medknow Publications journal@jovr.org, 2015) Totan, Yüksel; Koca, Cemile; Erdurmuş, Mesut; Keskin, Uğurcan; Yiğitoğlu, Ramazan
    Purpose: To evaluate plasma levels of endothelin-1 (ET-1) and nitric oxide (NO) in patients with exudative age-related macular degeneration (AMD). Methods: In this study, ET-1 levels, as well as nitrite plus nitrate concentrations as an indicator of plasma NO level, were measured in the plasma of 20 subjects with exudative AMD and compared with 20 healthy age and sex matched controls. Results: Mean plasma ET-1 level was significantly higher in exudative AMD patients as compared to control subjects (0.35 ± 0.06 fmol/ml versus 0.17 ± 0.03 fmol/ml, P = 0.015). Patients with exudative AMD also showed significantly lower mean plasma levels of nitrite plus nitrate as compared to the controls (58.9 ± 2.7 ?mol/l versus 82.6 ± 5.9 ?mol/l, P = 0.001). Conclusion: Increased concentrations of ET-1 and reduced levels of NO in the plasma may suggest an imbalance between vasoconstrictor and vasodilator agents, respectively, as a reflection of endothelial dysfunction in the pathogenesis of AMD. These findings may also imply the role of vasoconstriction in exudative AMD. © 2020 Elsevier B.V., All rights reserved.
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    Phakic pattern pseudoexfoliation material accumulation on intraocular lens surface
    (Turkish Ophthalmology Society info@oftalmoloji.com, 2014) Güler, Emre; Tenlik, Aylin; Kara Akyüz, Tuba; Erdurmuş, Mesut; Feyzi Hepşen, Ibrahim
    Pseudophakic pseudoexfoliation is the accumulation of pseudoexfoliation material on the intraocular lens. Most of the cases have showed scattered flecks of pseudoexfoliation material on the surface of the intraocular lens. However, the phakic pattern consisting of classic three-zone on the intraocular lens is rarely observed. In this case report, we describe a phakic pattern pseudoexfoliation material on the intraocular lens surface 8 years after cataract extraction. © 2014 Elsevier B.V., All rights reserved.