Yazar "Fernandes, Matheus Santos de Sousa" seçeneğine göre listele

Listeleniyor 1 - 4 / 4
  • Küçük Resim Yok
    Öğe
    Effect of high time under tension strength training on different muscular actions in the performance of runners: A randomized controlled trial
    (Public Library Science, 2026) Martins, Julio Cesar de Carvalho; Fernandes, Matheus Santos de Sousa; Aidar, Felipe J.; de Carvalho e Silva, Gustavo Ivo; Alves Filho, Eder Magnus Almeida; Yagin, Fatma Hilal; de Souza, Raphael Fabricio
    Background Strength training (ST) for runners is typically based on low volumes and high intensities. However, alternative approaches emphasizing higher volume and lower intensity, such as protocols with high time under tension (TUT), remain underexplored in this population. Notably, the effects of high-TUT may vary depending on the predominant type of muscle contraction.Objectives To analyze the impact of strength training with high time under tension on different muscle actions in performance-related variables in runners.Methods Thirty-four physically active young males were randomly divided into three groups: dynamic strength training, isometric strength training, and a control group. Over four weeks, the training groups performed two weekly sessions of bodyweight exercises with equalized time under tension per set (84 s), adjusted according to the type of contraction. The primary outcomes were performance in a 3000-meter time trial, peak torque, countermovement jump, neuromuscular fatigue, internal running load, ground contact time, and vertical oscillation. The data were analyzed using a two-way repeated measures analysis of variance.Results Peak torque increased by 13.3% in the dynamic group and 14.2% in the isometric group, compared with 2.5% in the control, with statistical significance only for the isometric group (p = 0.034, d = 1.12). Vertical jump height improved by 5.4% in the dynamic group and 4.1% in the isometric group compared with 0.7% in the control (p = 0.003, d = 1.54 and p = 0.030, d = 1.13, respectively).Conclusion In conclusion, high time under tension strength training, both dynamic and isometric, improved neuromuscular characteristics in runners. However, these adaptations did not translate into significant changes in running performance or running economy over the duration of the intervention.Trial registration This trial was registered in the Brazilian Clinical Trials Registry (ReBEC) with the identifier RBR-686kqdx.
  • Küçük Resim Yok
    Öğe
    Effect of high time under tension strength training on different muscular actions in the performance of runners: A randomized controlled trial [2]
    (2026) Martins, Júlio César de Carvalho; Fernandes, Matheus Santos de Sousa; Aidar, Felipe J.; Silva, Gustavo Ivo de Carvalho E; Filho, Eder Magnus Almeida Alves; Yagin, Fatma Hilal; Souza, Raphael Fabricio de
    BACKGROUND: Strength training (ST) for runners is typically based on low volumes and high intensities. However, alternative approaches emphasizing higher volume and lower intensity, such as protocols with high time under tension (TUT), remain underexplored in this population. Notably, the effects of high-TUT may vary depending on the predominant type of muscle contraction. OBJECTIVES: To analyze the impact of strength training with high time under tension on different muscle actions in performance-related variables in runners. METHODS: Thirty-four physically active young males were randomly divided into three groups: dynamic strength training, isometric strength training, and a control group. Over four weeks, the training groups performed two weekly sessions of bodyweight exercises with equalized time under tension per set (84 s), adjusted according to the type of contraction. The primary outcomes were performance in a 3000-meter time trial, peak torque, countermovement jump, neuromuscular fatigue, internal running load, ground contact time, and vertical oscillation. The data were analyzed using a two-way repeated measures analysis of variance. RESULTS: Peak torque increased by 13.3% in the dynamic group and 14.2% in the isometric group, compared with 2.5% in the control, with statistical significance only for the isometric group (p = 0.034, d = 1.12). Vertical jump height improved by 5.4% in the dynamic group and 4.1% in the isometric group compared with 0.7% in the control (p = 0.003, d = 1.54 and p = 0.030, d = 1.13, respectively). CONCLUSION: In conclusion, high time under tension strength training, both dynamic and isometric, improved neuromuscular characteristics in runners. However, these adaptations did not translate into significant changes in running performance or running economy over the duration of the intervention. TRIAL REGISTRATION: This trial was registered in the Brazilian Clinical Trials Registry (ReBEC) with the identifier RBR-686kqdx. Copyright: © 2026 Martins et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
  • Küçük Resim Yok
    Öğe
    Modulation of the serotonergic system restores oxidative balance and gene expression in the brain and heart of rats with obesity induced by overnutrition
    (Frontiers Media Sa, 2026) de Lemos, Maria Daniele Teixeira Beltrao; Fernandes, Matheus Santos de Sousa; Rodrigues, Thyago de Oliveira; de Souza, Vanessa Lima; Yagin, Fatma Hilal; Cassia de Andrade Silva, Severina; Lagranha, Claudia J.
    Introduction Studies have demonstrated that insults during development increase the risk for developing diseases later in life, including hypertension, ischemic heart disease, stroke, respiratory disease, diabetes, cancer, as well as psychiatric disorders. Hence, as mitochondrial dysfunction-induced oxidative stress has been proposed to be a central molecular hub linking metabolic and oxidative stress pathways, the serotonin modulation-related mitochondrial boost might mitigate such impairments. Thus, the present study investigates the effects of serotonina modulation by uoxetine on oxidative stress and mitochondrial biogenesis biomarkers in the brainstem and heart of male rats that were overfed during lactation period.Methods Normo and overfed animals received uoxetine (FX, SSRI) or saline from postnatal day 39 to postnatal day 59, wherein tissues were collected 24 hours later.Results and discussion Overfeeding increased body weight and induced lipid peroxidation and protein oxidation in both tissues, while genes related to mitochondrial dynamics (PGC1a and TFAM) were speci cally modulated, suggesting a targeted effect of uoxetine on mitochondrial biogenesis pathways by overfeeding across the tissues. Together, our results suggest that early life overfeeding deregulates oxidative balance and mitochondrial biogenesis, wherein FX administration acts toward molecular normalization both in heart and brainstem of male offspring. These ndings shed light on the potential of serotonin modulation to mitigate the effects of overnutrition during developmental periods.
  • Küçük Resim Yok
    Öğe
    Three weeks of environmental enrichment enhance hepatic-muscular oxidative balance and decrease interleukin-6 levels in juvenile female C57BL/6 mice
    (Frontiers Media Sa, 2025) Fidelis, Debora Eduarda da Silva; Fernandes, Matheus Santos de Sousa; Ramos, Tiago Lacerda; Silva, Clarice Beatriz Goncalves; Perreira, Allifer Rosendo; Nobrega, Cassia Giselle de Olivera; Souto, Fabricio Oliveira
    Introduction The Environmental Enrichment (EE) promotes systemic responses through social, cognitive, sensory, and physical stimuli. However, its effects on hepatic and muscle oxidative balance, as well as on serum inflammation markers, remain unclear. Therefore, this study aimed to evaluate whether three weeks of EE could modulate hepatic and muscular oxidative balance and the inflammatory response in female C57BL/6 mice.Methods The animals were divided into two groups: EE (n = 13) and Standard Environmental (SE, n = 11) from postnatal day 35 to 60. The EE setting included inanimate objects such as tunnels, ladders, and toys made of both wood and plastic. After three weeks, the mice were euthanized for the withdrawal of the liver, extensor digitorum longus (EDL), soleus, and blood samples.Results and discussion EE significantly reduced body weight and malondialdehyde levels in the liver, soleus, and EDL muscles. Additionally, carbonyl levels decreased in the liver and soleus. Acute EE exposure enhanced enzymatic antioxidant activity (SOD, CAT, and GST) across all tissues, except for catalase activity in the EDL, which showed no significant difference between groups. Non-enzymatic defenses were improved, with reduced oxidized glutathione (GSSG) levels in the liver and soleus. Furthermore, EE increased the REDOX status in the liver and EDL. Sulfhydryl levels increased only in the liver. Finally, serum cytokine analysis revealed a significant reduction only in IL-6 levels. These findings suggest that three weeks of EE can modulate hepatic and muscular oxidative balance, as well as serum IL-6 levels, in juvenile female mice.