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    A Cross-Sectional Analysis of Psychological and Dermatologic Manifestations Post-February 6 Earthquakes in Dermatology Patients
    (Korean Dermatological Assoc, 2026) Gencoglu, Sule; Cansel, Neslihan
    Background: Earthquakes are major natural disasters that can trigger both psychological and dermatological disturbances. The complex interaction between post-disaster mental health and skin disease remains underexplored, particularly beyond the acute phase. Objective: To investigate the prevalence of anxiety, depression, and post-traumatic stress disorder (PTSD) and their associations with dermatologic diagnoses in patients attending a dermatology clinic one year after the February 6, 2023 earthquakes in T & uuml;rkiye. Methods: This cross-sectional study included 673 dermatology outpatients who had resided in Malatya during the earthquakes. Sociodemographic and clinical data were collected. Psychological distress was assessed using the Hospital Anxiety and Depression Scale and Posttraumatic Stress Disorder-Short Scale. Results: Clinically significant anxiety, depression, and PTSD were observed in 44.0%, 69.2%, and 15.8% of participants, respectively. The most frequent dermatologic diagnoses were telogen effluvium (18.7%), pruritus (16.0%), and urticaria (10.1%). Telogen effluvium was more common among patients with anxiety (p=0.004) and PTSD (p=0.009), whereas alopecia areata and psoriasis showed higher rates in patients with anxiety and depression (p<0.05). Female sex, a history of psychiatric illness, and high education level were associated with the presence of PTSD. Conclusion: High levels of psychological distress persist among dermatology patients even one year after the earthquakes, underscoring the importance of integrated dermatologic and mental health assessment.
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    The Role of Long Pentraxin 3 and Nuclear Factor Kappa Beta in Vitiligo Occurrence and Disease Severity
    (Wiley, 2023) Gencoglu, Sule; Kanat, Zekiye
    Objectives. To reveal the role of long pentraxin 3 (PTX3) and nuclear factor kappa beta (NF-kB) in vitiligo and their relationship with disease severity. Materials and Methods. The study groups consisted of a total of 54 patients, including 27 patients diagnosed with vitiligo and 27 healthy controls without any cutaneous disease. Patients with amelanotic, sharply demarcated, and chalk-white macular lesions were defined as vitiligo. The diagnosis of vitiligo was confirmed by Wood's lamp examination. No biopsies were taken from the lesions, and no additional laboratory testing was performed. Skin and hair pigmentations in lesions other than hands and feet were evaluated. Vitiligo grading was done using the largest macules overall. Spreading rates were evaluated in selected lesions with Wood's lamp. The long pentraxin 3 and NF-kB levels in serum samples of participants were measured by the ELISA method. Results. According to the Vitiligo European Task Force consensus 16 of 27, vitiligo patients were in the slow progressive phase, and 11 patients were in the active progressive phase. The serum PTX3 levels of the patients in the vitiligo group were found to be significantly higher than those of the control group (8.21 +/- 2.11 ng/ml vs. 6.76 +/- 1.90 ng/ml, < 0.03). Similarly, the serum NF-kB levels of the patients in the vitiligo group were significantly higher than those of the patients in the control group (15.03 +/- 3.45 ng/ml vs. 12.19 +/- 4.20 ng/ml, < 0.01). A positive and significant correlation was found between serum NF-kB and PTX3 (r = 0.677 and < 0.01). PTX3 and NF-kB levels were significantly higher in patients in the active progressive phase than in patients in the slow progressive phase. PTX3 and NF-kB values in the active progressive phase tended to be higher than those detected when the disease was in the slow progressive phase. Conclusions. High serum PTX3 and NF-kB levels in vitiligo are evidence of impaired proinflammatory activity and innate and adaptive immunity.