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Öğe Ameliorative Effects of Larazotide Acetate on Intestinal Permeability and Bacterial Translocation in Acute Pancreatitis Model in Rats(Springer, 2024) Karahan, Dogu; Harputluoglu, Muhsin Murat Muhip; Gul, Mehmet; Gunduz, Ayten; Ozyalin, Fatma; Inceoglu, Feyza; Satilmis, BasriBackground Intestinal barrier dysfunction in acute pancreatitis (AP) may progress to systemic inflammatory response syndrome (SIRS) and multi-organ failures by causing bacterial translocation. Larazotide acetate (LA) is a molecule that acts as a tight junction (TJ) regulator by blocking zonulin (Zo) receptors in the intestine. Aims In our study, we aimed to investigate the effects of LA on intestinal barrier dysfunction and bacterial translocation in the AP model in rats. Methods Thirty-two male Sprague-Dawley rats were divided into 4 groups; control, larazotide (LAR), AP, and AP + LAR. The AP model was created by administering 250 mg/100 g bm L-Arginine intraperitoneally 2 times with an hour interval. AP + LAR group received prophylactic 0.01 mg/mL LA orally for 7 days before the first dose of L-Arginine. For intestinal permeability analysis, fluorescein isothiocyanate-dextran (FITC-Dextran) was applied to rats by gavage. The positivity of any of the liver, small intestine mesentery, and spleen cultures were defined as bacterial translocation. Histopathologically damage and zonulin immunoreactivity in the intestine were investigated. Results Compared to the control group, the intestinal damage scores, anti-Zo-1 immunoreactivity H-Score, serum FITC-Dextran levels and bacterial translocation frequency (100% versus 0%) in the AP group were significantly higher (all p < 0.01). Intestinal damage scores, anti-Zo-1 immunoreactivity H-score, serum FITC-Dextran levels, and bacterial translocation frequency (50% versus 100%) were significantly lower in the AP + LAR group compared to the AP group (all p < 0.01). Conclusions Our findings show that LA reduces the increased intestinal permeability and intestinal damage by its effect on Zo in the AP model in rats, and decreases the frequency of bacterial translocation as a result of these positive effects.Öğe An evaluation of the test-retest reliability of the functional head impulse test in healthy young adults(Springer, 2023) Kirazli, Gulce; Emekci, Tugba; Inceoglu, Feyza; Akmese, Pelin Pistav; Celebisoy, NeseAimTo determine the test and retest reliability of the functional head impulse test (fHIT) in healthy young adults.Materials and methodsThirty-three healthy participants (17 women, 16 men) aged 18-30 years were included in the study. Each participant underwent the fHIT twice, 1 week apart, by the same experienced clinician. Intraclass correlation coefficients (ICCs) were used to determine test-retest reliability.ResultsThere was no statistically significant difference between the results of total percentage of correct answer (CA%) of the fHIT obtained in session 1 and session 2 measurements in the lateral, anterior, and posterior semicircular canals (SCCs) (p > 0.05). ICC values for test-retest reliability were found to range from 0.619 to 0.665 for the three semicircular canals (SCCs).ConclusionThe test-retest reliability of the fHIT device was moderate. Attention, cognition, and fatigue may be the factors reducing reliability. In the diagnosis, follow-up, and rehabilitation processes of vestibular diseases in clinics, changes in the fHIT CA% can be used to assess vestibulo-ocular reflex (VOR) functionality.Öğe Association of 2D:4D finger length ratio of People Working in different professions with personality traits(Cell Press, 2024) Uzun, Gokce Bagci; Inceoglu, FeyzaBackground: The ratio of the index finger (2nd finger) to the ring finger (4th finger) (2D:4D) can give information about harmony between personality and career of individuals. The developing technology makes it difficult to choose a profession. Aim: This study aims to contribute to the career choice of individuals by analyzing the relationship between the 2D:4D finger digit ratio and personality traits of individuals working in different professions (Educator, Worker, Housewife, Civil servant, Healthcare professional/EWHCH). Method: The participants were three hundred twenty-five individuals living in the province of Malatya. The SPSS 26.0 software was utilized in the data analysis. The p value of 0.05 was accepted as significance level in comparison tests. Results: A statistically significant difference was determined between the participants, who had the 2D shorter than the 4D in right hand, in terms of professional groups (p < 0.05). In healthcare workers, a low level (r = 0.305) positive correlation was found between right hand 2D4D and both control (r = 0.264) and curiosity and left hand 2D:4D, and a low level (r = 0.255) negative correlation was found between Conscientiousness and right hand 2D:4D in housewives. There was a statistically significant difference between the groups (educator, worker, housewife, civil servant, healthcare professional) in terms of total score of the Five-Factor Personality Inventory (FFPI) and scores of extroversion, agreeableness, conscientiousness, neuroticism, and openness to experience subscales (p < 0.05). A weak positive statistically significant correlation was detected between the healthcare professionals' score of Career Adapt-abilities Scale (CAAS) control subscale and the right-hand 2D:4D ratio. Conclusions: It is suggested to investigate the 2D:4D ratio over different professional groups. The present study is important since it gives information about personality and associates such information with the 2D:4D ratio.Öğe Association of 2D:4D finger length ratio of People Working in different professions with personality traits (vol 10, e32332, 2024)(Cell Press, 2024) Uzuna, Gokce Bagci; Inceoglu, Feyza[Abstract Not Available]Öğe Association of HIF1α, BNIP3, and BNIP3L with Hypoxia-Related Metabolic Stress in Metabolic Syndrome(Mdpi, 2026) Kiran, Tugba Raika; Keskin, Lezan; Erdem, Mehmet; Guctekin, Zeynep; Inceoglu, FeyzaBackground and Objectives: Metabolic syndrome (MetS) is a complex condition marked by insulin resistance, central obesity, dyslipidemia, and chronic inflammation. Emerging evidence highlights the roles of hypoxia and mitochondrial stress in its pathophysiology. Hypoxia-inducible factor-1 alpha (HIF1 alpha) and the mitophagy-associated proteins BNIP3 and BNIP3L are key components of hypoxia-responsive mitochondrial stress signaling. This study aimed to evaluate the circulating levels of HIF1 alpha, BNIP3, and BNIP3L in MetS and to explore their associations with metabolic and inflammatory parameters. Materials and Methods: Serum concentrations of HIF1 alpha, BNIP3, and BNIP3L were measured by ELISA in 40 patients with MetS and 40 age and sex-matched controls. Biochemical, hematological, and anthropometric parameters were assessed, and receiver operating characteristic (ROC) analyses were performed to evaluate diagnostic performance. Results: Serum levels of HIF1 alpha, BNIP3, and BNIP3L levels were significantly higher in MetS patients compared with controls (p = 0.001). ROC analysis demonstrated strong diagnostic potential, particularly for BNIP3 (AUC = 0.928), followed by HIF1 alpha (AUC = 0.885) and BNIP3L (AUC = 0.770). These markers showed significant associations with metabolic indicators such as BMI, fasting glucose, triglycerides, and inflammatory markers. Conclusions: The coordinated upregulation of circulating HIF1 alpha, BNIP3, and BNIP3L in MetS is associated with metabolic dysregulation and systemic inflammation, reflecting alterations in hypoxia-responsive mitophagy-associated signaling rather than direct functional impairment of mitophagy. These findings support the potential relevance of these markers as indicators of metabolic stress in MetS. Further tissue-based and mechanistic studies are warranted to clarify their role in disease pathophysiology.Öğe Cancer Metastasis Prediction and Genomic Biomarker Identification through Machine Learning and eXplainable Artificial Intelligence in Breast Cancer Research(Mdpi, 2023) Yagin, Burak; Yagin, Fatma Hilal; Colak, Cemil; Inceoglu, Feyza; Kadry, Seifedine; Kim, JungeunAim: Method: This research presents a model combining machine learning (ML) techniques and eXplainable artificial intelligence (XAI) to predict breast cancer (BC) metastasis and reveal important genomic biomarkers in metastasis patients. Method: A total of 98 primary BC samples was analyzed, comprising 34 samples from patients who developed distant metastases within a 5-year follow-up period and 44 samples from patients who remained disease-free for at least 5 years after diagnosis. Genomic data were then subjected to biostatistical analysis, followed by the application of the elastic net feature selection method. This technique identified a restricted number of genomic biomarkers associated with BC metastasis. A light gradient boosting machine (LightGBM), categorical boosting (CatBoost), Extreme Gradient Boosting (XGBoost), Gradient Boosting Trees (GBT), and Ada boosting (AdaBoost) algorithms were utilized for prediction. To assess the models' predictive abilities, the accuracy, F1 score, precision, recall, area under the ROC curve (AUC), and Brier score were calculated as performance evaluation metrics. To promote interpretability and overcome the black box problem of ML models, a SHapley Additive exPlanations (SHAP) method was employed. Results: The LightGBM model outperformed other models, yielding remarkable accuracy of 96% and an AUC of 99.3%. In addition to biostatistical evaluation, in XAI-based SHAP results, increased expression levels of TSPYL5, ATP5E, CA9, NUP210, SLC37A1, ARIH1, PSMD7, UBQLN1, PRAME, and UBE2T (p <= 0.05) were found to be associated with an increased incidence of BC metastasis. Finally, decreased levels of expression of CACTIN, TGFB3, SCUBE2, ARL4D, OR1F1, ALDH4A1, PHF1, and CROCC (p <= 0.05) genes were also determined to increase the risk of metastasis in BC. Conclusion: The findings of this study may prevent disease progression and metastases and potentially improve clinical outcomes by recommending customized treatment approaches for BC patients.Öğe Classification of Osteophytes Occurring in the Lumbar Intervertebral Foramen(Mdpi, 2024) Tacyildiz, Abdullah Emre; Inceoglu, FeyzaBackground: Surgeons have limited knowledge of the lumbar intervertebral foramina. This study aimed to classify osteophytes in the lumbar intervertebral foramen and to determine their pathoanatomical characteristics, discuss their potential biomechanical effects, and contribute to developing surgical methods. Methods: We conducted a retrospective, non-randomized, single-center study involving 1224 patients. The gender, age, and anatomical location of the osteophytes in the lumbar intervertebral foramina of the patients were recorded. Results: Two hundred and forty-nine (20.34%) patients had one or more osteophytes in their lumbar 4 and 5 foramina. Of the 4896 foramina, 337 (6.88%) contained different types of osteophytes. Moreover, four anatomical types of osteophytes were found: mixed osteophytes in 181 (3.69%) foramina, osteophytes from the lower endplate of the superior vertebrae in 91 (1.85%) foramina, osteophytes from the junction of the pedicle and lamina of the upper vertebrae in 39 foramina (0.79%), and osteophytes from the upper endplate of the lower vertebrae in 26 (0.53%) foramina. The L4 foramen contained a significantly higher number of osteophytes than the L5 foramen. Osteophyte development increased significantly with age, with no difference between males and females. Conclusions: The findings show that osteophytic extrusions, which alter the natural anatomical structure of the lumbar intervertebral foramina, are common and can narrow the foramen.Öğe Correlation of Neuroanatomical Structures Related to Speech in Cerebral Palsy Patients Aged 0-17: A Retrospective MRI Study(Mdpi, 2025) Berk, Erhan; Uzumcuoglu, Rumeysa; Inceoglu, Feyza; Aydin, Merve; Arpaci, Muhammed Furkan; Sigirci, Ahmet; Pekmez, HidirBackground/Objectives: Cerebral Palsy (CP) is a non-progressive clinical condition characterized by secondary issues, including speech impairments. Our study aims to evaluate the volumes of brain areas related to speech in patients diagnosed with CP between the ages of 0-17. Methods: this study includes the images of 84 children: 42 in the control group who applied to the hospital between the specified dates and were reported as healthy by MRI from the patient records, and 42 patients with CP. Results: in the CP group, white and gray matter, cerebrum, cerebellum, thalamus, lobus frontalis, lobus temporalis, lobus parietalis, lobus insularis, gyrus cinguli, and nuclei basales volumes were observed to decrease statistically significantly compared to the control group (p < 0.001). Conclusions: we found a significant decrease in the volumes of speech-related brain areas in CP patients, indicating that CP can significantly impact the brain's speech-related regions.Öğe Determining medical students' anxiety and readiness levels about artificial intelligence(Cell Press, 2024) Guven, Gamze Ozbek; Yilmaz, Serife; Inceoglu, FeyzaThe aim of this study is to determine the levels of anxiety and readiness among medical students regarding artificial intelligence (AI) and examine the relationship between these factors. The research was conducted on medical students, and the data was collected through face-to-face and online surveys between April and June 2022. The study utilized a socio-demographic information form, an AI anxiety scale, and a medical AI readiness scale. The data collected from a total of 542 students were analyzed using the Statistical Program for Social Sciences (SPSS) version 25. Cronbach's alpha coefficient was used for reliability analysis. A path diagram was created using AMOS 24, and structural equation modelling (SEM) analysis was applied. The findings of the study indicate that medical students have a moderate level of readiness and a high level of anxiety regarding AI. Furthermore, an inverse relationship was found between AI readiness and AI anxiety. These results highlight the importance of increasing the preparedness of medical students for AI applications and reducing their anxieties. The study suggests the inclusion of AI in the medical curriculum and the development of a standardized curriculum to facilitate its teaching.Öğe Determining the relationship between e-health literacy and personal health system and patient satisfaction using structural equation model: an example of a training and research hospital(Bmc, 2025) Koca, Mehmet; Inceoglu, Feyza; Deniz, SerdarBackground In the current technology landscape, several individuals electronically stores their health information. The personal health system offers significant conveniences to users, hence enhancing patient satisfaction. Assessing the impact of e-health literacy, personal health system, and patient happiness on enhancing patient satisfaction an essential outcome of health services is crucial for system improvement and clarity. This study sought to assess the impact of patients' e-health literacy levels, evaluated at a training and research hospital, on personal health systems and patient satisfaction. Methods The research was carried out in a teaching and research hospital associated with the Ministry of Health in Malatya province from March 15, 2024, until April 25, 2024. The research was executed with data from 275 people. The data collection form consists of 4 sections. Results In the present study, 275 people participated, and 57.8% of them were women. 3.69 were the mean score for the personal health system utilization perception, 92.64 was the mean score for the outpatient satisfaction scale, and 3.63 were the mean score for the e-health literacy scale. E-health literacy explained 2% (R-2 = 0.02) of outpatient satisfaction and e-health literacy and outpatient satisfaction explained 30% (R-2 = 0.30) of the perception of personal health system use. Conclusion Outpatient satisfaction influences individuals' perceptions of their health system, e-health literacy affects outpatient satisfaction, and outpatient satisfaction serves as a mediator between e-health literacy and personal health system perspectives.Öğe Does Tourniquet Use Affect the Length of the Hamstring Tendon in Anterior Cruciate Ligament Reconstruction?(Mdpi, 2026) Altunkilic, Tarik; Ari, Bunyamin; Guzel, Ismail; Boz, Mehmet; Inceoglu, FeyzaBackground: The aim of the present study was to investigate whether the use of a tourniquet during anterior cruciate ligament reconstruction affects the length of the hamstring tendon used for autograft. Methods: Adult patients who were referred to the Orthopedics and Traumatology Department of The Malatya Turgut & Ouml;zal University hospital and were diagnosed with anterior cruciate ligament injury between 30 July 2025 and 30 December 2025 were included in the study. In total, 31 patients from whom the hamstring tendon was harvested without a tourniquet were placed in Group 1, and 36 patients from whom the hamstring tendon was harvested with a tourniquet were placed in Group 2. This study is a prospective, randomized, comparative study. These two groups were compared with respect to the lengths of the hamstring tendons used as autografts. Results: The semitendinosus and gracilis tendon lengths in Group 1 were 29.61 +/- 1.76 cm and 27.68 +/- 2.02 cm, respectively. In Group 2, the semitendinosus and gracilis tendon lengths were 25.67 +/- 1.45 cm and 23.72 +/- 1.06 cm, respectively. A statistically significant difference was observed between the semitendinosus and gracilis tendon lengths of the participants in Groups 1 and 2 (p < 0.05). Conclusions: These findings suggest that avoiding tourniquet use during hamstring tendon harvest may represent a simple technical modification that can influence harvested tendon length during anterior cruciate ligament reconstruction.Öğe Effects of the Kahramanmaras, Turkey 2023 earthquakes on balance perception, dizziness and post-traumatic stress: A relational screening model between subjective balance problems and post-traumatic stress(Elsevier Sci Ltd, 2024) Cengiz, Deniz Ugur; Inceoglu, Feyza; Karababa, Ercan; Polat, Ani Parabakan; Yilmaz, Tugba; Kuntman, Berna Deniz; Hizal, EvrenObjective: The aim of the present study was to investigate the effects of the February 6, 2023, earthquakes in Turkey and recurrent aftershocks on balance and post-traumatic stress in surviving victims. Methods: Our study included 1004 participants aged 18 -65 years who were exposed to the February 6 earthquakes and aftershocks in Turkey. After obtaining online consent from all participants, the Vertigo Symptom Scale (VSS), the Dizziness Handicap Index (DHI), and the Posttraumatic Post-Traumatic Disorder Checklist Scale (PCL-5) were administered online, and the interactions between the variable sets were examined using a correlational screening model. Results: As a result of the structural equation model established with the observed variables, it was found that VSS total scores had a statistically significant positive effect on PCL-5 (beta 1 = 0.56; p = 0.001 < 0.05). In addition, statistically significant positive high-level correlations were found between VSS and DHI (cov(VSS-DH)I = 0.71), and a positive low level correlation with the number of days with dizziness (cov(VSS-number of days with dizziness) = 0.34), and a positive low level correlation with frequency of days with dizziness (cov VSS-frequency of days with dizziness = 0.37). A statistically significant positive low-level relationship was found between DHI and the number of days with dizziness (cov(DHI-number of days with dizziness) = 0.34) and a positive low-level correlation between DHI and the frequency of days with dizziness (cov(DHI-frequency of days with dizziness) = 0.29). Conclusion: The structural equation modeling analysis showed that post-traumatic stress disorder had a significant effect on balance and dizziness.Öğe Endoplasmic reticulum stress and oxidative imbalance is the missing link in fibromyalgia pathophysiology(Nature Portfolio, 2025) Otlu, Onder; Kiran, Tugba Raika; Baykara, Rabia Aydogan; Erdem, Mehmet; Inceoglu, FeyzaFibromyalgia syndrome (FMS) is a chronic pain disorder characterized by widespread musculoskeletal pain, fatigue, and cognitive dysfunction. Although its exact pathophysiology remains unclear, emerging evidence suggests that endoplasmic reticulum (ER) stress and oxidative stress play significant roles in its development. This study aimed to investigate the involvement of ER stress in FMS by evaluating key ER stress markers and oxidative stress parameters in patients with FMS. A total of forty-four FMS patients and matched healthy controls were included in the study. Serum levels of ER stress markers were measured using enzyme-linked immunosorbent assay (ELISA). Additionally, oxidative stress markers were assessed to examine their relationship with ER stress in FMS. The ER stress parameters were significantly higher in the FMS group compared to controls. Furthermore, oxidative stress markers were elevated, reinforcing the interconnection between ER stress and oxidative stress in FMS pathogenesis. These findings suggest that ER stress plays a crucial role in the pathophysiology of FMS, likely contributing to disease progression through oxidative stress-related mechanisms. Targeting ER stress and oxidative stress pathways may represent a promising therapeutic strategy for FMS management. Future studies should focus on large-scale clinical investigations to further elucidate these pathways and develop effective treatment approaches.Öğe Evaluation of Earthquake Survivors of the February 6 Turkey Earthquakes: The Mediating Role of Hopelessness in the Relationship Between Psychological Resilience and Posttraumatic Embitterment Symptoms(Korean Neuropsychiatric Assoc, 2026) Akan, Mustafa; Unal, Suheyla; Inceoglu, FeyzaObjective Following the February 6 earthquakes, survivors faced intense psychological distress, including feelings of disappointment, perceived injustice, and anger-leading to adverse effects on their well-being. Although earthquakes are not human-induced, the abundance of human errors further exacerbated the situation. These outcomes may have triggered symptoms of Posttraumatic Embitterment Disorder (PTED) among survivors. The present study examined the mediating role of hopelessness in the relationship between this resilience and PTED symptoms among individuals who experienced the February 6 earthquakes. Methods This cross-sectional online study was conducted in Malatya, one of the severely affected regions, between July 20, 2023 and January 20, 2024. Participants completed the PTED Scale, the Psychological Resilience Scale, the Beck Hopelessness Scale, and a sociodemographic form through an online survey. The data obtained were analyzed, and structural equation modeling was performed. Results The final sample included 801 participants (mean age=37.82 +/- 11.03 years), of whom 48.6% (n=389) exhibited PTED symptoms. Hopelessness was found to mediate the relationship between psychological resilience and embitterment. Together, psychological resilience and hopelessness accounted for 43.7% of the variance in embitterment (R2=0.437). Conclusion PTED should be considered among the psychological outcomes of earthquakes. The findings highlight the therapeutic potential of hope-based interventions for PTED and underscore the importance of preventive measures targeting vulnerable populations in disaster-affected regions. Our findings can guide health authorities in structuring post-disaster mental health services and assist in developing health policies in this regard. Psychiatry Investig 2026;23(4):548-555Öğe Evaluation of possible associated factors for early childhood caries: are preterm birth and birth weight related?(Bmc, 2024) Selen, Merve Bilmez; Demir, Pinar; Inceoglu, FeyzaBackgroundThis study aimed to evaluate the oral and dental health of preschool children aged 12-71 months living in the Eastern Anatolia Region of Turkey, and to examine the effects of low birth weight (LBW) and preterm, early term and term birth on dental caries.Methods475 participants were included in the study. Intraoral examinations were performed and evaluated for the presence of early childhood caries (ECC). These values are; Relationships such as age, gender, birth weight, week of birth, tooth brushing frequency, cariogenic nutrition, and parental education levels were examined. The obtained data were analyzed statistically (chi-square, t-test, artificial neural network (ANN)).ResultsOf the 475 participants, whose parents agreed to fill out the questionnaire, 250 were female and 225 were male. While the mean age was 49.78 +/- 14.78 months for those with ECC, it was 38.93 +/- 17.96 months for those without. Higher duration of breastfeeding (p = 0.04), education level of parents (p = 0.001), lower socioeconomic level (p = 0.001), and lower brushing frequency (p = 0.001) were also found to be significantly associated with ECC. ECC was seen in 90% of 77 children with a history of preterm birth. In LBW, this rate was 83%. According to the ANN result, in preterm birth; 12.9% affected ECC by LBW.ConclusionAccording to the results of our study, both LBW and preterm delivery were found to be associated with ECC and S-ECC (severe early childhood caries). An additional study on parents of preterm/LBW infants would be beneficial. In the early period, regular dental examination, implementation of preventive and preventive treatments, and nutrition education to parents can make a significant difference in the prevention of ECC.Öğe Evaluation of second trimester plasma lipoxin A4, VEGFR-1, IL-6, and TNF-a levels in pregnant women with gestational diabetes mellitus(De Gruyter Poland Sp Z O O, 2023) Kiran, Tugba Raika; Melekoglu, Rauf; Otlu, Onder; Inceoglu, Feyza; Karabulut, Ercan; Erenler, Ayse SebnemIn this study, our objective was to explore the association between gestational diabetes mellitus (GDM) and second trimester maternal plasma levels of lipoxin A4 (LXA4), along with proinflammatory markers such as interleukin-6 (IL-6) and tumour necrosis factor alpha (TNF-a), and the anti-angiogenic factor vascular endothelial growth factor receptor 1 (VEGFR-1) in pregnant women. The study included a cohort of 30 pregnant women with GDM and a control group of 30 normoglycaemic pregnant women matched for age, body mass index, and gestational age. Plasma samples were collected and analysed by enzyme-linked immunosorbent assay to assess specific biomarkers. The GDM group had significantly lower levels of LXA4 and higher levels of TNF-a and VEGFR-1 compared to the control group (p = 0.038, p = 0.025, and p = 0.002, respectively). A statistically significant decrease in the LXA4/TNF-a ratio was observed in the GDM group (p = 0.004). The results suggest that each unit decrease in the LXA4/TNF-a ratio is associated with a 1.280-fold increase in the risk of GDM. These findings suggest a potential diagnostic role for the LXA4/TNFa ratio as a marker for women with GDM. This work provides new insights into the pathogenesis of GDM and highlights the important interplay between inflammation and metabolic dysregulation.Öğe Evaluation of the use of the central physician appointment system and patient satisfaction in a training and research hospital: A cross-sectional study(Lippincott Williams & Wilkins, 2025) Koca, Mehmet; Deniz, Serdar; Inceoglu, FeyzaThis study aimed to determine the usage status of the central physician appointment system (CPAS) by patients visiting the outpatient clinic of a tertiary hospital and their level of satisfaction with the healthcare services they receive. The sample of this study consisted of 291 patients who received outpatient services at a tertiary healthcare institution in Malatya. The data collection form consisted of 2 sections. The data collection form consisted of 2 parts. The first section included sociodemographic information, and the second section included the Outpatient Satisfaction Scale. In the present study, 291 people participated, of whom 52.9% (n = 154) were female. The findings showed that 17.5% (n = 51) of the study group had no information about the appointment system. Those who had not yet made an appointment with CPAS (by themselves or anyone else) constituted 23.4% (n = 68) of the sample. In addition, 63.2% (n = 141) of those who had made an appointment at least once before this study had made their appointments online (CPAS). The average Outpatient Satisfaction Scale score of the group was 3.40. Gender and income affected patient satisfaction, but there was no significant correlation with other demographic variables. It was determined that the most satisfied issue was Effective Inspection. The least satisfied issue was the Waiting Time and Consultancy dimension.Öğe Evaluation Turkish Academic and Student Attitudes on Plagiarism: Validity and Reliability of the Plagiarism Attitudes Scale(Sage Publications Inc, 2024) Ozbek Guven, Gamze; Inceoglu, Feyza; Yilmaz, Serife; Ince, FuatThe main purpose of this study was to translate the Plagiarism Attitude Scale into Turkish and validate it for use in Turkish settings, in order to better understand research integrity attitudes and awareness of the Turkish academic and student community, while also contributing an instrument for research in this area. The research was designed and conducted with 483 participants. In the process of adapting the scale to Turkish, language, content, and construct validity analyses were performed. Following the completion of the validity phase, the reliability of the scale was examined using Cronbach's alpha coefficient and the split-half method. The results indicate that the scale's language and content validity are deemed sufficient. According to the findings of the research, the Plagiarism Attitude Scale, in its adapted Turkish version, is considered a valid and reliable tool. The use of this Turkish scale will assist local researchers in sharing their unique perspectives and help the international community better understand research ethics concerns in Turkiye. Additionally, this scale will serve as a valuable resource for planning educational programs.Öğe Explaining sleep disorders in children after earthquakes using SHAP modelling: Container City modelling(Elsevier Science Inc, 2026) Yayan, Emriye Hilal; Inceoglu, Feyza; Duken, Mehmet Emin; Dag, Yeliz Suna; Zengin, MursideBackground: It is well-known that sleep disturbances and sleep-related traumas are the most common symptoms experienced by children following a traumatic event. Our study aims to predict the factors affecting post-traumatic sleep disorders in children living in container cities by using machine learning models. Methods: This descriptive, cross-sectional study determined the average age of the children to be 13.72 +/- 2.35 years. Research data were obtained using a child information form and a sleep disorder scale for children. A study of 1085 children living in container cities used logistic regression, random forest and XG-Boost models to make predictions and calculate accuracy metrics. Based on the assessment, sleep disorders were present in 600 children (55.3%), while the remaining 485 (44.7%) exhibited no such disorders. Results: The comparison revealed that the XGBoost model achieved the best performance, with an accuracy of 0.89, an F1 score of 0.87, a negative predictive value of 0.89, a precision of 0.90 and a recall of 0.85. Conclusions: Based on the SHAP importance values derived from the model, 'sleep problem situation' was identified as the most influential feature, while 'having shelter problems in an earthquake' was found to be the least influential. These findings highlight key associations that can inform the development of rehabilitation service plans and guide further investigation into factors related to sleep disorders in children during traumatic periods. Implications for practice: This study suggests that psychiatric and paediatric nursing practice and education should include strategies to intervene with children after natural disasters. (c) 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.Öğe Interleukin-37 and interleukin-39 as novel immunometabolic biomarkers in metabolic syndrome: A cross-sectional study(Lippincott Williams & Wilkins, 2026) Keskin, Lezan; Kiran, Tugba Raika; Erdem, Mehmet; Inceoglu, FeyzaMetabolic syndrome (MetS) is characterized by abdominal obesity, dyslipidemia, hypertension, and insulin resistance, all driven by chronic low-grade inflammation. This study aimed to evaluate serum interleukin-37 (IL-37) and interleukin-39 (IL-39) levels as potential immunometabolic biomarkers in MetS. Eighty adults (40 MetS patients, 40 healthy controls) were enrolled based on NCEP ATP III criteria. Anthropometric, biochemical, and hormonal parameters were assessed. Serum IL-37 and IL-39 concentrations were measured using ELISA. Statistical analyses included t-tests, Pearson correlations, logistic regression, and receiver operating characteristic curve analysis. Both IL-37 and IL-39 levels were significantly elevated in MetS compared with controls (P <.001). Logistic regression revealed that each 1 pg/mL increase in IL-37 and IL-39 was associated with 1.01-fold (P = .017) and 1.06-fold (P = .001) higher odds of MetS, respectively. receiver operating characteristic analysis showed excellent discriminative ability for IL-39 (AUC = 0.96; 95% confidence intervals: 0.91-1.00) and good accuracy for IL-37 (AUC = 0.82; 95% confidence intervals: 0.73-0.91). Among classical parameters, waist circumference (AUC = 1.00), TG (AUC = 0.93), and fasting glucose (AUC = 0.88) showed the strongest diagnostic power. HDL cholesterol exhibited inverse association (AUC = 0.83), while systolic and diastolic blood pressure showed moderate accuracy (AUC = 0.85 and 0.71, respectively). IL-37 and IL-39 were elevated in individuals with MetS and showed strong discriminative performance, particularly IL-39. These cytokines may reflect underlying immunometabolic alterations and could provide complementary information alongside established metabolic parameters. However, given the cross-sectional design and modest sample size, these findings should be considered exploratory and require validation in larger, longitudinal studies to determine their clinical relevance.
