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Öğe Effects of new NHC derivatives as ligands in the Suzuki–Miyaura reaction(Taylor & Francis, 2021) Yılmaz, Ülkü; Küçükbay, HasanA series of NHC-derivative ligands was synthesized from bisbenzimidazole salts as the precursor of N-heterocyclic carbene with chalcogens, carbon disulfide, and phenyl isothiocyanate reagents. These new ligands were used in the Suzuki–Miyaura cross-coupling reaction in the presence of palladium(II) acetate. Particularly, it was observed a remarkable ligand activity with tellurourea (5).Öğe Investigation of the cytotoxic and antimicrobial properties of new quinoline peptide conjugates(Malatya Turgut Özal Üniversitesi, 2024) Adıyaman, Emine; Katrancıoğlu, Özgür; Apohan, Elif; Küçükbay, HasanBackground: Cancer is one of the most important health problems causing deaths in Turkey and the world. Nowadays, many treatment methods such as radiotherapy and chemotherapy are applied in cancer patients. Quinoline and its derivatives, which belong to heterocyclic compounds, have many biological activities for drug development. Quinoline compounds play a crucial role in the development of antitumor drugs due to their anticancer activity. Materials and Methods: In this study, the cytotoxic effects of synthesized seven different quinoline derivatives on lung cancer (A549) and healthy lung epithelial cell (BEAS2B), liver cancer (Hep 3B), and endothelial cell (HUVEC) were determined. Different concentrations were applied and IC50 values were calculated at different time courses. The antimicrobial activites of the compounds were also determined. Results: The IC50 values of compound 2 on the A549 cell line were determined to be 10.48 ?g/mL, 9.738 ?g/mL, and 10.14 ?g/mL. IC50 values of compound 6 on the same cell line were determined to be 7.307 µg/mL, 9.888 µg/mL, 10.63 µg/mL. Conclusions: Compounds 2 and 6 had a cytotoxic effect on the BEAS2B cell line. The antimicrobial activity of the compounds was determined by the minimum inhibition concentration method on different strains of bacteria and yeast. The compounds showed no antimicrobial activity on bacteria and yeast.Öğe Synthesis a group of 5(6)-substituted benzimidazole Zn(II) and Co(II) complexes and investigation their cytotoxic and antimicrobial activities(2022) Yılmaz, Ülkü; Apohan, Elif; Küçükbay, Hasan; Yılmaz, Özgür; Tatlıcı, Eray; Yeşilada, ÖzferA series of 5(6)-substituted benzimidazole ligand-zinc(II) and cobalt(II) complexes were synthesized and characterized by 1H, 13C NMR, IR, CHN analysis techniques. In vitro, anticancer and antimicrobial activities of ligand and complexes were evaluated. The cytotoxic activities of compounds were investigated against the human lung adenocarcinoma (A549) cell lines and healthy human lung bronchial epithelium (BEAS2B) cells. Compounds 1, 6, and 8 were observed to exhibit higher cytotoxic activity than the others at the 72nd hour. Also, the compounds showed varying degrees of antimicrobial activity against the microorganisms used. Compounds 1, 5, and 8 were most effective against standard strains Pseudomonas aeruginosa ATCC 27853 and Staphylococcus aureus ATCC 29213. As for the antifungal activity, compounds 1, 5, 6, and 8 showed high antifungal activity against the yeast type fungi Candida albicans ATCC 90028 and Candida tropicalis.Öğe Synthesis and evaluation of anticancer properties of novel benzimidazole ligand and their cobalt(II) and zinc(II) complexes against cancer cell lines A-2780 and DU-145(Elsevier, 2019) Yılmaz, Ülkü; Tekin, Suat; Buğday, Nesrin; Yavuz, Kemal; Küçükbay, Hasan; Sandal, SüleymanEighteen new cobalt(II) or zinc(II) complexes of benzimidazole bearing 1-benzyl and 2-phenyl moieties were synthesized from the reaction of appropriate benzimidazole ligands and CoCl2 or ZnCl2. Their structural characterizations were done by IR, NMR (1H, 13C) and UV–VIS spectrometers. Cytotoxic activities of eighteen new complexes and three benzimidazole ligands were determined using A-2780 (human ovarian) and DU-145 (human prostate) cell lines. Antitumor properties of all compounds were determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Cell viability assay for the tested benzimidazole derivatives was performed and the LogIC50 values of the compounds were calculated after a 24-hour treatment. All tested benzimidazole derivatives showed higher or comparable antitumor activity against A-2780 cell lines compared to the standard drug docetaxel with a LogIC50 value of ?0.81?µM (p?Öğe Synthesis of New Bisbenzimidazole Salts and Determination Their Ligand Activities in C-C Coupling Reactions(Malatya Turgut Ozal University, 2020) Yılmaz, Ülkü; Küçükbay, HasanNew bisbenzimidazole salts were synthesized with 1,4-bis(1H-benzo[d]imidazol-1-yl)butane and benzyl halides. These new ligands carried out in Suzuki-Miyaura and Heck-Mizoroki C-C coupling reaction in the presence of palladium(II) acetate. It was observed that remarkable ligand activities of these benzimidazolium halides (L1, L2, L3).
