Yazar "Kaplan, Fatih" seçeneğine göre listele
Listeleniyor 1 - 5 / 5
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe Atopic Features and Inflammatory Markers Across Cassano-Graded Adenoid Hypertrophy(Mdpi, 2026) Kaplan, Fatih; Kurnaz Kaplan, Bilge; Gulyuz, AbdulganiHighlights What are the main findings? center dot In children with adenoid hypertrophy, disease severity was independently associated with eosinophilia rather than with IgE-mediated sensitization. center dot Family history of atopy and elevated total IgE were the strongest factors associated with clinical atopy. What is the implication of the main finding? center dot Inflammatory burden may play a more important role than classical allergic sensitization in determining adenoid hypertrophy severity. center dot Evaluation of eosinophilia may provide additional clinical information in the routine assessment of children with adenoid hypertrophy.Highlights What are the main findings? center dot In children with adenoid hypertrophy, disease severity was independently associated with eosinophilia rather than with IgE-mediated sensitization. center dot Family history of atopy and elevated total IgE were the strongest factors associated with clinical atopy. What is the implication of the main finding? center dot Inflammatory burden may play a more important role than classical allergic sensitization in determining adenoid hypertrophy severity. center dot Evaluation of eosinophilia may provide additional clinical information in the routine assessment of children with adenoid hypertrophy.Highlights What are the main findings? center dot In children with adenoid hypertrophy, disease severity was independently associated with eosinophilia rather than with IgE-mediated sensitization. center dot Family history of atopy and elevated total IgE were the strongest factors associated with clinical atopy. What is the implication of the main finding? center dot Inflammatory burden may play a more important role than classical allergic sensitization in determining adenoid hypertrophy severity. center dot Evaluation of eosinophilia may provide additional clinical information in the routine assessment of children with adenoid hypertrophy.Highlights What are the main findings? center dot In children with adenoid hypertrophy, disease severity was independently associated with eosinophilia rather than with IgE-mediated sensitization. center dot Family history of atopy and elevated total IgE were the strongest factors associated with clinical atopy. What is the implication of the main finding? center dot Inflammatory burden may play a more important role than classical allergic sensitization in determining adenoid hypertrophy severity. center dot Evaluation of eosinophilia may provide additional clinical information in the routine assessment of children with adenoid hypertrophy.Abstract Background: Evidence linking adenoid hypertrophy (AH) and atopy is conflicting. We examined whether Cassano-graded AH severity is more closely associated with inflammatory markers than with IgE-mediated sensitization. Methods: We retrospectively included children aged 3-12 years diagnosed with AH between December 2022 and December 2025. AH was graded according to the Cassano classification and dichotomized as advanced AH (Stage III-IV). Atopic features were evaluated separately as clinical atopy, IgE-mediated sensitization, elevated total IgE, and eosinophilia. Multivariable logistic regression analyses were performed to assess factors associated with clinical atopy, sensitization, and advanced AH. Results: Among 426 children, clinical atopy was present in 28.2%, sensitization in 23.0%, elevated total IgE in 16.4%, and eosinophilia in 27.7%; 39.2% had advanced AH. In multivariable analysis, clinical atopy was independently associated with family history of atopy (aOR 13.9; 95% CI 7.9-24.4), elevated total IgE (aOR 3.86; 95% CI 2.10-7. 08), and passive smoking exposure (aOR 1.73; 95% CI 1.07-2.79). Sensitization was independently associated only with family history of atopy (aOR 4.99; 95% CI 1.99-12.53). Advanced AH was independently associated only with eosinophilia (aOR 2.07; 95% CI 1.30-3.29). Conclusions: AH severity was associated with eosinophilia rather than classical IgE-mediated sensitization. Assessment of eosinophilia may aid routine severity evaluation in children with AH.Öğe Clinical Implications of Post-Earthquake Environmental Exposures in Children with Allergic Diseases(Mdpi, 2026) Kaplan, Fatih; Kurnaz Kaplan, Bilge; Arikanoglu, Emrullah; Gulyuz, AbdulganiHighlights What are the main findings? Post-earthquake environmental exposures were associated with worsening disease control in children with allergic diseases. Prolonged residence in temporary housing and exposure to demolition-related dust were independently associated with clinical deterioration, particularly among children with asthma. What are the implications of the main findings? Children with chronic allergic diseases should be considered a vulnerable population in post-disaster settings. Dust-control measures, air-quality monitoring, and improved living conditions in temporary housing may help reduce post-disaster worsening of allergic diseases.Highlights What are the main findings? Post-earthquake environmental exposures were associated with worsening disease control in children with allergic diseases. Prolonged residence in temporary housing and exposure to demolition-related dust were independently associated with clinical deterioration, particularly among children with asthma. What are the implications of the main findings? Children with chronic allergic diseases should be considered a vulnerable population in post-disaster settings. Dust-control measures, air-quality monitoring, and improved living conditions in temporary housing may help reduce post-disaster worsening of allergic diseases.Abstract Background/Objectives: Environmental changes following large-scale natural disasters may influence the clinical course of chronic diseases. However, the impact of post-earthquake environmental exposures on pediatric allergic diseases remains insufficiently studied. To evaluate the association between post-earthquake environmental exposures and disease control in children with allergic diseases. Methods: This retrospective longitudinal cohort study included 528 children with previously diagnosed asthma, allergic rhinitis, or atopic dermatitis who were followed in a tertiary pediatric allergy center in Malatya, T & uuml;rkiye. Clinical assessments performed before the 6 February 2023 Kahramanmara & scedil; earthquakes (T0) were compared with follow-up evaluations conducted 6-12 months after the earthquake (T1). Environmental exposures assessed during the post-earthquake period included prolonged residence in temporary housing, demolition-related dust exposure, and elevated ambient particulate matter levels. Clinical deterioration was defined using disease-specific indicators (decline in ACT/cACT score or treatment step escalation for asthma, increase in TNSS for allergic rhinitis, and increase in SCORAD for atopic dermatitis). Multivariable logistic and linear regression models were used to evaluate associations between environmental exposures and clinical outcomes. Results: Clinical deterioration was observed in 219 children (41.5%). Prolonged residence in temporary housing for >= 6 months (aOR 2.1, 95% CI 1.2-3.9, p = 0.01) and exposure to demolition-related dust (aOR 1.9, 95% CI 1.1-3.5, p = 0.02) were independently associated with clinical deterioration. Among children with asthma, both prolonged temporary housing (adjusted beta -1.84, p = 0.002) and demolition-related dust exposure (adjusted beta -1.39, p = 0.018) were associated with worsening asthma control. Conclusions: Post-earthquake environmental exposures, particularly prolonged residence in temporary housing and demolition-related dust exposure, were associated with worsening control of pediatric allergic diseases. These findings highlight the importance of environmental health considerations in disaster response and long-term management of children with chronic allergic conditions.Öğe Knowledge level of anaphylaxis management and epinephrine use among health professionals: a cross-sectional evaluation of audiologists(MediHealth Academy Yayıncılık, 2026) Kaplan, Fatih; Kaplan, Bilge Kurnaz; Gülyüz, AbdulganiAims: Anaphylaxis is a severe systemic hypersensitivity reaction with sudden onset and rapid progression that can be fatal if early intramuscular epinephrine is not administered. Although audiologists frequently work with pediatric and allergic patient populations, their competence in recognizing and managing anaphylaxis has not been systematically evaluated. The aim of this study was to assess audiologists’ knowledge levels regarding anaphylaxis, to identify critical life-saving knowledge gaps, and to determine independent predictors of correct epinephrine and auto-injector use. Methods: In this cross-sectional study, 189 audiologists completed a 22-item knowledge questionnaire covering the definition of anaphylaxis, triggers, clinical manifestations, first-line treatment, epinephrine administration route and dose, and auto-injector use. A total knowledge score (range: 0-22) was calculated. Three critical outcomes were analyzed separately: knowledge that epinephrine is the first-line treatment for anaphylaxis, knowledge that epinephrine should be administered intramuscularly, and knowledge of the correct epinephrine dose (0.01 mg/kg). Independent predictors were evaluated using multivariable logistic regression analysis. Results: The median total knowledge score was 12 (range: 1-22), and the internal consistency of the questionnaire was good (Cronbach’s α=0.793). Only 50.8% of participants correctly identified epinephrine as the first-line treatment for anaphylaxis, 34.4% knew that epinephrine should be administered intramuscularly, and 42.9% knew the correct epinephrine dose. Awareness of epinephrine auto-injectors was identified as the strongest independent predictor of correct dose knowledge (adjusted odds ratio [aOR] 4.28; 95% CI 1.94-9.46; p<0.001). Professional experience significantly predicted knowledge of intramuscular administration (aOR 1.07; p=0.008). Conclusion: Although overall knowledge of anaphylaxis among audiologists was moderate, only 50.8% identified epinephrine as first-line treatment, 34.4% knew the intramuscular route, and 42.9% knew the correct dose. Awareness of auto-injectors was strongly associated with correct dose knowledge (aOR 4.28). These findings highlight critical gaps in life-saving knowledge and the need for targeted training programs.Öğe Mucous Stools in Infancy as an Early Marker of the Atopic March: A Four-Year Cohort Study of Respiratory Atopy Risk(Mdpi, 2026) Kaplan, Fatih; Gulyuz, AbdulganiBackground: Mucous stools in infancy are commonly attributed to non-IgE-mediated gastrointestinal food allergies and are generally considered transient and benign. However, whether mucous stools may indicate an atopy-prone clinical phenotype and relate to later respiratory atopy remains insufficiently explored. Objective: To evaluate the long-term risk of respiratory atopy (asthma and/or allergic rhinitis) in infants presenting with mucous stools during the first year of life and to identify early clinical predictors of this risk. Methods: This retrospective cohort study included infants who presented with mucous stools within the first 12 months of life and were followed for four years. Baseline demographic, clinical, dietary, and laboratory data were extracted from standardized medical records. Mucus severity was graded using a pragmatic 0-3 clinical mucus score. The primary outcome was physician-diagnosed asthma and/or allergic rhinitis at four years. Multivariable logistic regression was used to identify independent predictors, with model discrimination assessed by the area under the receiver operating characteristic curve (AUC). Results: A total of 142 infants with complete follow-up data were analyzed. At four years, respiratory atopy was observed in 45 infants (31.7%). In multivariable analysis, family history of atopy (adjusted odds ratio [aOR] 2.68, 95% CI 1.20-5.98, p = 0.016) and wheezing at presentation (aOR 3.74, 95% CI 1.56-8.94, p = 0.003) were independent predictors of respiratory atopy. The mucus score was associated with respiratory atopy in univariable analysis but did not remain an independent predictor in multivariable modeling. The model showed good discrimination (AUC = 0.769). Conclusions: In this cohort of infants presenting with mucous stools in the first year of life, respiratory atopy was observed in nearly one-third by age 4. While mucous stool burden was associated with the outcome in univariable analyses, it did not remain an independent predictor after adjustment. Early wheezing and a family history of atopy were the strongest clinical predictors and may help identify infants who warrant closer follow-up. These findings should be interpreted as associative and hypothesis-generating in the absence of a mucous-stool-free comparison group.Öğe Prevalence of allergic diseases and associated risk factors in audiologists(MediHealth Academy Yayıncılık, 2026) Kaplan, Fatih; Kaplan, Bilge Kurnaz; Arıkanoğlu, Emrullah; Gülyüz, AbdulganiAims: To determine the prevalence of allergic diseases among actively working audiologists in Turkiye and to evaluate the association between allergic diseases and smoking, family history of atopy, and occupational factors. Methods: This cross-sectional study included 220 actively working audiologists across Turkiye. Data on demographic characteristics, smoking status, family history of atopy, and physician-diagnosed allergic diseases (asthma, allergic rhinitis, allergic conjunctivitis, atopic dermatitis, and food allergy) were collected. Respiratory and allergic symptoms were assessed using the core questionnaire of the European Community Respiratory Health Survey (ECRHS). The presence of at least one physician-diagnosed allergic disease was defined as the primary outcome. Factors associated with allergic disease were analyzed using univariable and multivariable logistic regression models. Results: The mean age of participants was 31.2±6.4 years, and 68.2% were female. Among all participants, 27.3% were current smokers and 41.8% reported a family history of atopy. At least one physician-diagnosed allergic disease was present in 35.9% of audiologists. The most common conditions were allergic conjunctivitis (24.5%), allergic rhinitis (21.8%), and atopic dermatitis (18.6%). Wheezing during the past 12 months was reported by 31.8% of participants, nocturnal respiratory symptoms by 29.5%, and current asthma medication use by 16.8%. In multivariable analysis, smoking (adjusted OR=1.77; 95% CI: 1.04–3.01; p=0.034) and family history of atopy (adjusted OR=1.75; 95% CI: 1.03–2.98; p=0.038) were independently associated with the presence of allergic disease. Conclusion: Allergic diseases and respiratory allergic symptoms are common among actively working audiologists in Türkiye. Smoking and family history of atopy are independent risk factors for allergic disease. These findings highlight the need for early recognition of allergic conditions, smoking cessation, and preventive strategies to reduce occupational exposures in this professional group.
