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Öğe A society, a disease, a survey and the expected result(2023) Demir, Bilgehan; Karahan, DoğuCOVID-19, which affects the whole world, has affected people, societies and human relations throughout the process. The COVID-19 pandemic both limited people's social lives and changed the perspective of people who carry the virus. Anxiety, fear, haste, loneliness, worry were the most common emotions. In this study, we aimed to evaluate how social warnings affect people, the effects of death risk due to the disease, the side effects of the drugs used on behavior change, and the underlying factors. 189 cases were included in the study. The study was designed in the style of a 20-question questionnaire on the effects of covid-19 and treatment options on the behavior pattern. The responses were evaluated and interpreted as percentages. Variables on family and social behavior related to anxiety, fear, panic, and loneliness caused by COVID-19 and the drugs used in its treatment were observed. Negative effects of COVID-19 were observed in family and community relations. COVID-19 has caused psychological and sociological changes in interpersonal and social behaviors all over the world. There are differences in behavioral patterns among societies. In Turkish society, behavioral changes arising from the characteristic and patriarchal characteristics of the society have been observed. A more detailed assessment of the effects of COVID-19 and subsequent pandemics on the individual and society remains important.Öğe Course of COVID-19 in patients carrying different MEFV mutations of familial Mediterranean fever(2024) Demir, Bilgehan; Karahan, DoğuFamilial Mediterranean fever (FMF) is a genetic auto-inflammatory disease. Mutations in the Mediterranean fever (MEFV) gene cause inappropriate immune system triggering, leading to inflammatory episodes in the peritoneum, pleura, and joints. In the severe Coronavirus disease-19 (COVID-19) picture, the hyperimmune response and inflammatory process develop with exacerbation of the clinical condition. FMF disease, the drugs used in its treatment, and the possible effects of different genetic MEFV mutations on the course of COVID-19 arouse interest. In this study, 158 FMF patients with different MEFV gene mutations were evaluated using an online survey method in terms of COVID-19 course, hospitalization, additional comorbidities, and COVID-19 vaccination status. Participants were asked 21 questions and the data provided were compared between FMF MEFV gene mutations. 104 out of 158 cases did not get COVID-19. 9 of 54 cases who got COVID-19 were hospitalized. No statistically significant difference was found between MEFV gene mutations when evaluated and compared in terms of susceptibility to COVID-19, vaccination status, and presence of additional chronic diseases and comorbidities. The present study provides guidance on the role of FMF genetic mutations in the course of COVID-19. Our study may suggest that FMF MEFV gene mutations do not have a protective role against COVID-19. The results also may suggest that, as an inverse effect, MEFV gene mutations do not increase the risk of hyper-immune response and severe acute respiratory syndrome (SARS), which play a role in the severe course of COVID-19.Öğe Determining the role of HLA-B27 on COVID-19(2023) Karahan, Doğu; Demir, BilgehanAim: Human leukocyte antigen-B27 (HLA-B27) binds antigenic peptides in the structure of some viruses and presents them to cytotoxic T lymphocytes and plays a role in the immune response against these viruses. It has also been found to be associated with auto-immunity as an inverse relationship and is associated with a number of auto-immune inflammatory diseases, especially Ankylosing Spondylitis (AS). Our aim in this study is to determine the role of HLA-B27 in Severe Acute Respiratory Syndrome (SARS)-Cov-2 (Coronavirus Disease-COVID-19). Materials and Methods: 90 HLA-B27 positive and 96 HLA-B27 negative cases were included in the study. COVID-19 Polymerase Chain Reaction (PCR) results and Thorax Computed Tomography (CT) results, hospitalization and death records of the cases were retrospectively analyzed from the system records. Results were compared between HLA B27 positive and negative groups. Results: Of the HLA-B27 positive cases, 32.2% had COVID-19 positivity, 5.6% had COVID-19 lung involvement. 44.8% of HLA-B27 negative cases had COVID-19 positivity and 11.5% had lung involvement. There was no significant difference between the HLA-B27 positive and negative groups in terms of having COVID-19 infection, lung involvement, hospitalization and death rates. Conclusion: The results of our study show that HLA-B27 does not have a protective role in terms of having COVID-19 and lung involvement. Again, since no auto-immunity related SARS was observed in any of the patients, it can be said that it did not increase the severity of the hyper-immunity-related disease and did not increase the risk of death in particular for COVID-19. These results need to be supported by more studies.Öğe Evaluation of local and systemic side effects of Turkovac vaccine in adults(2023) KALAYCI, BÜLENT NURİ; Karahan, DoğuBackground/aim: COVID-19 is a respiratory disease that caused a pandemic after reportedly emerging from Wuhan, China, in December 2019. Different types of COVID-19 vaccines such as viral vectors, mRNA, and inactivated vaccines have been produced since the beginning of the pandemic. Turkovac is an inactive COVID-19 vaccine developed and produced in Türkiye. We conducted our study to investigate the local and systemic side effects of the Turkovac vaccine. Materials and methods: A cross-sectional survey-based study was conducted to collect data on the postvaccine side effects in people aged over 18 who were vaccinated with Turkovac, between March and June 2022, in the Malatya Turgut Özal University Research and Training Hospital. A 54 question, multiple-choice questionnaire was used to collect demographic data from the participants and identify the possible local and systemic side effects after Turkovac vaccine administration. Results: Of the 403 participants included in the study, 134 (33.3%) were female and 269 (66.7%) were male with a mean age of 47.7 ± 13.7. The most common local side effects observed after vaccination were pain at the injection site (22.8%) and local swelling and redness (0.5%). Systemic side effects included weakness or fatigue (4.2%), muscle or joint pain (2%), headache (1.7%), fever (1%), cough (0.25%), lymphadenopathy (0.25%), and urticaria (0.25%). Side effects were most commonly observed within the first 24 h. We found that for participants under 47 years of age, female sex, chronic diseases, and regular medication use were associated with the risk of suffering side effects. Conclusion: Our study revealed that Turkovac is a generally well-tolerated vaccine and had no side effects. More studies are required to evaluate Turkovac’s side effects in other populations.Öğe Sandfly Fever-Related Acute Hepatitis Outbreak After Kahramanmaraş Earthquake(2024) Karahan, Doğu; dal, şirvan elmas; Yılmaz, Nazlı Gül; , Haci mehmetIntroduction: Sandfly fever virus, a member of the Phlebovirus (Bunyaviridae family), can cause sandfly fever, also known as “Pappataci fever”. This vector-related disease occurs primarily in endemic regions during the summer months. Epidemics may develop in different regions if favorable environmental conditions and vector transport are present. Laboratory changes, such as elevated transaminases and creatine kinase levels, leukopenia, and thrombocytopenia, may be observed in sandfly fever. In this study, we aimed to evaluate the laboratory results and progression of sandfly fever cases, which were concentrated in the conditions developing in the earthquakeaffected region. Materials and Methods: Seventeen sandfly fever cases who were followed up in our clinic between August and October 2023 were included in the study. These cases were patients who presented with non-specific complaints related to infection in the earthquakeaffected area after the February 6 Kahramanmaraş earthquake and had acute hepatitis with elevated transaminases, creatine kinase, and C-reactive protein (CRP). The study retrospectively evaluated the laboratory results and findings of cases positive for the sandfly fever virus. Results: Of the cases, 58.8% were male (n= 10), 41.2% were female (n= 7), with a mean age of 40.88 ± 19.59. The mean aspartate aminotransferase (AST) was calculated as 325.53 U/L, alanine aminotransferase (ALT) as 311.88 ± 282.36 U/L, alkaline phosphatase (ALP) as 109.64 ± 49.59 U/L, gamma-glutamyl transferase (GGT) as 80.82 ± 71.05 U/L, lactate dehydrogenase (LDH) as 564.47 ± 404.57 IU/L and creatine kinase (CK) as 872.38 U/L. Of the 17 cases, nine had leukopenia (53%), nine had neutropenia (53%), and five had lymphopenia (29.4%). Thrombocytopenia was observed in seven cases (41.1%). The mean CRP level was high at 3.78 mg/dL. Acute renal failure was also present in three cases. The cases were discharged after supportive treatment and observation, with improvements in both clinical and laboratory findings. Conclusion: Our study showed that sandfly virus-related epidemics may occur, particularly during warm months, when suitable conditions develop, such as after an earthquake. Additionally, it was determined that an acute hepatitis presentation, characterized by a significant increase in transaminases and creatine kinase, can be observed in sandfly virus infection. Our study also indicates that caution should be exercised regarding the potential for larger and more serious epidemics that may affect the region, especially during the summer months, if current conditions persist.
