Yazar "Kaya, Mesut" seçeneğine göre listele
Listeleniyor 1 - 12 / 12
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe Are newborn intensive care units suitable for hearing screening?(Cocuk Sagligi ve Hastaliklan Dergisi muratyurdakok@yahoo.com, 2016) Kaya, Mesut; Unsal, Selim; Yilmaz, Ceyda Sel; Genç, Meltem; Turan, Selma; Gündüz, MehmetTo evaluate the noise levels in the neonatal intensive care unit and discuss their suitability for neonatal hearing screening environment, a descriptive cross-sectional study was carried out in nine neonatal intensive care units in Bursa during June 2015. Sound intensity level measurements were recorded each 10 seconds for 15 minutes, at 1 hour before, during and 1 hour after breastfeeding of neonates between 8 am and 5 pm. Recordings showed that the sound levels of all ICUs of nine hospitals are above 40 dB, the limits of National Noise Regulation Standards. Our study reveals that neonatal intensive care unit environment is not suitable for neonatal hearing screening test administration; with false positive results. This may cause adverse effects on family, the physicians and national economy. © 2017 Elsevier B.V., All rights reserved.Öğe Chronologic Presentation of a Severe Case of Progressive Hemifacial Atrophy (Parry-Romberg Syndrome) with the Loss of an Eye(Hindawi Ltd, 2014) Kaya, Mesut; Yilmaz, Ceyda Sel; Kurtaran, Hanifi; Gunduz, MehmetProgressive hemifacial atrophy, also known as Parry-Romberg syndrome, is a slowly advancing degenerative disease that mostly affects the cutaneous, subcutaneous fatty tissue, muscle tissue, and bone structures on one side of the face. We describe the chronological progression of this very rare syndrome from early childhood until adulthood in a patient who developed severe atrophy and lost one eye. We also discuss the aetiology and pathophysiology of this syndrome.Öğe Effect of Voice Hygiene Education on Voice Quality of Teachers(Int Organization Center Acad Research, 2016) Genc, Dilsat; Kaya, Mesut; Gunduz, MehmetIn this study, we handled the teachers who use their voices and sounds in order to teach. Because their voices are their instruments to teach, they use it frequently. That's why our teachers are under great risk of having voice problems and diseases The purpose of this work, finding a meaningful contribution on the improvement of the quality of teachers' voices by comparison before and 4 weeks after the completion of the voice hygiene education to them. The teachers are selected from public schools and private courses within the province of Ankara. The voice hygiene education was given to 32 teachers in total: 10 female and 6 male teachers who work full time (6-12 hours) and 10 female and 6 male teachers who work part time (1-4 hours). As a control group, the voice hygiene education was not given to 38 teachers in total: 8 female and 12 male teachers who work full time (6-12 hours) and 10 female and 8male teachers who work part time (1-4 hours). The complete experiment group consists of 70 people. As a subjective evaluation method, voice handicap index and survey is used. Electroglottography (EGG) which is used in acoustic analysis was preferred as an objective test material, Measuring teachers' voices and using MDUP analysis program, Fo, % jitter, % shimmer and MFZ parameters were used as data. Every voice sample for every subject was analyzed by computer program. To evaluate the effects of voice hygiene course, UHI was filled before, during and after the 4-weeks voice hygiene education. The grading of UHI results we used are min.13 and max.65. The evaluated UHI results were 13 - 39 points. After giving hygiene education, the average UHI point was decreased by 5.22 points compared to UHI values before giving hygiene education (p < 0.000). The significant decrease of total points after giving hygiene education was observed. Positive emotional, psychological and social effects occurred on teachers. It can be said that the approximate MFZ values of subject group after giving hygiene education are higher than 1.69 compared to before giving hygiene values (p = 0.000) to evaluate the vocal performance on MFZ tests. The significantly high MFZ values are thought to be related with voice hygiene education. In our study, there is no significant difference observed in Fo, % jitter and % shimmer values, due to the perturbation parameters before and after hygiene (p > 0.05). When the mean values are observed from the parameters, it is seen that there were minimal decrements. The decrease in these values gives rise to thought that the voice hygiene course affects the healing side positively. After giving voice hygiene education, the observed decrease in these values are thought to be related with closeness of voice cords, tension and the decrease in voice quality caused by reduced tension. The voice hygiene education given to teachers is observed to be helpful. It is thought to reduce the probability of having bad use of voice as a permanent habit and helpful about early diagnosis and treatment. It is concluded that the usage of voice course and voice hygiene course should be included in vocational training program.Öğe Evaluation of Acoustic Reflex and Reflex Decay Tests in Geriatric Group(Galenos Yayincilik, 2016) Unsal, Selim; Karatas, Havva; Kaya, Mesut; Gumus, Nebi Mustafa; Temugan, Esra; Yuksel, Mustafa; Gunduz, MehmetObjective: To determine average acoustic reflex thresholds in geriatric groups by assessing ipsilateral and contralateral acoustic reflex and reflex decay tests. Methods: A total of 25 elders between ages 65-84 years (74.3 +/- 5.4) and 25 individuals between ages 18-45 years (30.4 +/- 4.2) were recruited for the study. After ear, nose, and throat examination, ipsilateral and contralateral acoustic reflex thresholds at 500, 1000, 2000, and 4000 Hertz (Hz) were determined and a reflex decay test at contralateral 500 Hz was conducted. Ipsilateral acoustic reflex thresholds were obtained with high-frequency band, low-frequency band, and wide band noise, and the results were compared with ipsilateral acoustic reflexes at 500, 1000, 2000, and 4000 Hz. Results: There was no statistically significant difference between the two groups in ipsilateral and contralateral acoustic reflex measurements at 500, 1000, 2000, and 4000 Hz (p>0.05). Negative reflex decay was obtained in all participants and no statistically significant difference between the two groups was observed in terms of reflex decay thresholds (p>0.05). Acoustic reflex with high-frequency band noise was observed in five of nine elders whose acoustic reflexes were not obtained at 2000 and 4000 Hz, whereas acoustic reflex with low-frequency band noise was observed in one of six elders who did not show reflexes at 500 and 1000 Hz. Conclusion: It was concluded that although some changes were observed due to age, middle ear and stapes muscles work normally in geriatric group. In the reflex decay test, reliable results were obtained at contralateral 500 Hz. Acoustic reflex measurements with low-and high-frequency band noise may also be used to assess middle ear functions.Öğe Evaluation of eustachian tube function tests and immitancemetric measurements in a geriatric group(Geriatrics Society, 2016) Unsal, Selim; Yaman, Ünzile; Gümş, Nebi Mustafa; Kaya, Mesut; Temügan, Esra; Gecin, Mustafa Vecdi; Yüksel, Mustafa T.Introduction: Atrophy in the middle ear and degeneration of muscle fibers, fibrous tissue ligament, and bone as well as calcification of Eustachian cartilage occurs with aging. We aimed to evaluate the middle ear system and changes in Eustachian tube functions in a geriatric group. Materials and Method: Study participants comprised 30 older and 30 younger individuals between the age of 65 and 84 years (74.3±5.4 years) and 18 and 45 years (30.4±4.2 years), respectively. All participants underwent immitancemetric measurements and Eustachian tube function tests after ear, nose, and throat examination. For the immitancemetric measurements, the ear canal volume, compliance, middle ear pressure, and gradient were evaluated. Valsalva and Toynbee maneuvers were used to perform the Eustachian tube function tests. Results: Non-significant differences were found between the two groups for the ear canal volume and middle ear pressure (p>0.05). While no significant difference was found for the left ear compliance values between the two groups (p>0.05), a significant difference between the left ear compliance and gradient values for both ears was found (p<0.05). Eustachian tube function tests showed no significant differences between the groups, based on the values obtained by Valsalva and Toynbee maneuvers. Conclusion: Eustachian tube functions in the geriatric group were found to be normal in this study. Bilateral gradient and right ear compliance values were higher in the geriatric group than in the control group indicating that the middle ear system in the geriatric group was more active. © 2017 Elsevier B.V., All rights reserved.Öğe EVALUATION OF EUSTACHIAN TUBE FUNCTION TESTS AND IMMITANCEMETRIC MEASUREMENTS IN A GERIATRIC GROUP(Gunes Kitabevi Ltd Sti, 2016) Unsali, Selim; Yaman, Unzile; Gumus, Nebi Mustafa; Kaya, Mesut; Temugan, Esra; Gecin, Mustafa Vecdi; Yuksel, MustafaIntroduction: Atrophy in the middle ear and degeneration of muscle fibers, fibrous tissue ligament, and bone as well as calcification of Eustachian cartilage occurs with aging. We aimed to evaluate the middle ear system and changes in Eustachian tube functions in a geriatric group. Materials and Method: Study participants comprised 30 older and 30 younger individuals between the age of 65 and 84 years (74.3 +/- 5.4 years) and 18 and 45 years (30.4 +/- 4.2 years), respectively. All participants underwent immitancemetric measurements and Eustachian tube function tests after ear, nose, and throat examination. For the immitancemetric measurements, the ear canal volume, compliance, middle ear pressure, and gradient were evaluated. Valsalva and Toynbee maneuvers were used to perform the Eustachian tube function tests. Results: Non-significant differences were found between the two groups for the ear canal volume and middle ear pressure (p>0.05). While no significant difference was found for the left ear compliance values between the two groups (p>0.05), a significant difference between the left ear compliance and gradient values for both ears was found (p<0.05). Eustachian tube function tests showed no significant differences between the groups, based on the values obtained by Valsalva and Toynbee maneuvers. Conclusion: Eustachian tube functions in the geriatric group were found to be normal in this study. Bilateral gradient and right ear compliance values were higher in the geriatric group than in the control group indicating that the middle ear system in the geriatric group was more active.Öğe Functional analysis of ESM1 by siRNA knockdown in primary and metastatic head and neck cancer cells(Wiley, 2018) Bender, Onur; Gunduz, Mehmet; Cigdem, Sadik; Hatipoglu, Omer Faruk; Acar, Muradiye; Kaya, Mesut; Grenman, ReidarBackgroundGenetic factors play a large role in cancer, and thus, there is a great desire to understand the effects of different genes in cancer and to also develop gene therapy for better treatments. Therefore, the development of alternative diagnosis and therapy modalities is of utmost importance. The aim of our study was to illuminate the role of ESM1 (endothelial cell-specific molecule-1, also known as Endocan) in proliferation and migration of head and neck cancer, thus helping to pave the way for new treatment modalities and predictive biomarkers. MethodsESM1 expression was shown with immunofluorescence assay using confocal laser scanning microscope in primary and metastatic head and neck cancer cells. ESM1 expression was knocked down by RNA interference in head and neck cancer cells. Knockdown efficiency was evaluated by quantitative real-time RT-PCR and Western blot. Cell proliferation and migration assays were performed by xCELLigence real-time cell analysis system. ResultsImmunofluorescence assay showed nuclear localization and high expression of ESM1 in primary and metastatic head and neck cancer cells. ESM1 mRNA and protein levels were significantly decreased in ESM1-knockdown cells compared to control. ESM1-knockdown cells showed reduced proliferation and migration activity when compared to control cells. ConclusionThese findings suggest that ESM1 has roles on proliferation and migration of head and neck cancer cells.Öğe Long-term results of one staged multilevel surgery with tongue suspension surgery or one level palatal surgery for treatment of moderate and severe obstructive sleep apnea(Springer, 2016) Yuksel, Alper; Ugur, Kadriye Serife; Kizilbulut, Gultekin; Ark, Nebil; Kurtaran, Hanifi; Kaya, Mesut; Gunduz, MehmetThe objective of this study is to evaluate and compare the long-term efficacy of the one staged multilevel surgery (MLS) with tongue suspension (TBS) surgery or one level palatal surgery for treatment of moderate and severe obstructive sleep apnea (OSA). This is a prospective cross-sectional study. Setting: University hospital. Thirty-three patients diagnosed as moderate to severe OSA. Patients, with a parts per thousand yen50 % retropalopharyngeal obstruction on the Muller maneuver, were treated with palatal surgeries (PS) and patients, with a parts per thousand yen50 % retropalopharyngeal obstruction on the Muller maneuver with a parts per thousand yen50 % base of the tongue collapse, were treated with palatal surgeries and tongue suspension surgery (TBS). Patients were evaluated with one night polysomnography before the surgery and 24 months after the surgery. Patients completed Epworth sleepiness scale (ESS), snoring VAS (visual analog scale) before and 24 months after the surgery. Nine-teen patients with a mean age of 46.1 +/- A 8.3 underwent palatal surgeries (PS) and 14 patients with a mean age of 41.4 +/- A 8.9 underwent PS plus TBS. Success rate in TBS+PS group was 57.1 % and in PS group was 42.1 %. In both groups total apnea-hypopnea index (AHI) values significantly decreased after 2 years (p < 0.025) but there was no statistically significant difference between TBS+PS and PS groups. Supine AHI levels were reduced statistically significant in both groups postoperatively (p < 0.025). There was not any significant difference postoperatively in non-supine AHI levels in both groups (p > 0.025). There were significant postoperative changes in ODI, AVO2, MOS, ESS, Snoring VAS values in PS group (p < 0.025). In TBS+PS group there was a significant difference postoperatively only in ODI values. Treatment of OSA patients with retropalatal or retropalatal and retroglossal obstruction, in a one staged surgery, is a safe and easy procedure. We have achieved favorable long-term outcomes in moderate-severe OSA patients undergoing both palatal surgery and tongue suspension surgery.Öğe Retrospective air bone gap evaluation of patients with tympanic membrane central perforation(Canadian Soc Clinical Investigation, 2016) Kucukkavruk, Levent; Temugan, Esra; Kaya, Mesut; Unsal, Selim; Gumus, Nebi Mustafa; Yuksel, Mustafa; Gunduz, MehmetPurpose: The purpose of this study was to evaluate hearing recovery and air-bone gap (ABG) before and after tympanoplasty surgery in patients with tympanic membrane central perforation. Methods: Histories and audiological assessments of 160 cases (total of 26 ears from 22 patients; 11 men and 11 women) from patients who had undergone tympanoplasty surgery and hearing reconstruction due to tympanic membrane central perforation were evaluated. Pre-postoperative audiograms and the pure tone, air-bone hearing thresholds and ABG gains were evaluated. Results: The mean age of the patients was 38.6 years (+/- 16.04). The mean postoperative follow-up period was 13.4 months (+/- 15.5). The mean preoperative ABG was 25.36 dB (+/- 9.9) and postoperative ABG was 17.36 dB (+/- 11.68) (p = 0.001). When four groups were compared before surgery and after surgery period as 0-6 months, 6-12 months, 1-2 years and 2 years in terms of pre-and postoperative ABG values, no statistically significant difference was observed (p>0.05). All patients were divided into three groups: < 20 years of age; between the ages of 21-40; and, > 41 years of age, and no statistically significant difference were found between the groups (p>0.05). Surgeries of the patients 21-40 years of age were more successful (ABG gain) than other age groups. No statistically significant gender differences were found in ABG averages (p = 0.33), but clinical results were significantly better in women as compared with men. Conclusion: In patients with central tympanic membrane perforation, tympanoplasty surgery with temporal fascia is beneficial in terms of hearing recovery.Öğe Stafne bone cavity containing ectopic parotid gland(Assoc Brasileira Otorrinolaringologia & Cirurgia Cervicofacial, 2018) Kaya, Mesut; Ugur, Kadriye Serife; Dagli, Elif; Kurtaran, Hanifi; Gunduz, Mehmet[Abstract Not Available]Öğe The effect of different nasal irrigation solutions following septoplasty and concha radiofrequency: a prospective randomized study(Assoc Brasileira Otorrinolaringologia & Cirurgia Cervicofacial, 2018) Kurtaran, Hanifi; Ugur, K. Serife; Yilmaz, Ceyda Sel; Kaya, Mesut; Yuksel, Alper; Ark, Nebil; Gunduz, MehmetIntroduction: Nasal irrigation solutions are widely used following endonasal surgery. These irrigation solutions remove infective debris and crusts, reducing the probability of synechia formation, and accelerate mucosal healing. Objective: The aim of the present study was to compare the effects of nasal irrigation solutions with different contents following septoplasty and concha radiofrequency. Methods: The present study was a prospective, randomized, controlled simple blind study of 120 patients who underwent septoplasty and bilateral concha radiofrequency. Patients were divided into four groups according to the nasal irrigation solution used: tap water, buffered isotonic saline, saline with xylitol, and hypertonic sea water. Patients were examined on the 7th and 15th postoperative days. A saccharine test was applied to determine mucociliary activity preoperatively and on the 7th and 15th postoperative days. Patients were asked about drying and obstruction using a 10 cm visual analog scale. In addition, patients were examined to determine the crusting score. Results: There was no significant difference found in the preoperative and 7th and 15th postoperative days' mucociliary clearance times among the four groups. The crusting score was found to be significantly lower in the hypertonic sea water group (p < 0.001). Drying and obstruction on the 7th and 15th postoperative days were found to be significantly more comfortable in the hypertonic sea water group (p < 0.001). Conclusion: Hypertonic sea water is the recommended irrigation solution, as it is associated with Less crusting, drying, and obstruction in the nose for the postoperative period following septoplasty and concha radiofrequency. (C) 2017 Associacao Brasileira de Otorrinolaringologia e Cirurgia Cervico-Facial. Published by Elsevier Editora Ltda.Öğe The protective role of thymoquinone in the prevention of gentamicin ototoxicity(W B Saunders Co-Elsevier Inc, 2014) Sagit, Mustafa; Korkmaz, Ferhat; Gurgen, Seren Gulsen; Kaya, Mesut; Akcadag, Alper; Ozcan, IbrahimObjective: To investigate the potential protective effect of thymoquinone in gentamicin-induced ototoxicity through auditory brain stem responses (ABR) testing and histomorphological evaluation of the cochlea. Methods: This study was conducted on 48 adult female Sprague-Dawley rats that were randomized into 4 groups. Group 1 received intraperitoneal gentamicin; group 2 received intraperitoneal gentamicin plus corn oil solution; group 3 received intraperitoneal thymoquinone; and group 4 received intraperitoneal gentamicin plus thymoquinone. All groups received the drugs (once daily) in the above-mentioned protocols over 15 days. After conducting repeated ABR measurements, the rats were sacrificed, and their cochleae were isolated. Results: ABR thresholds were preserved in the gentamicin plus thymoquinone group when compared with the group receiving gentamicin alone. There were fewer TUNEL-positive cells and caspase-3 and caspase-9 expressions were weaker in the inner and outer hairy cells of the organ of Corti in the gentamicin plus thymoquinone group compared with the group receiving gentamicin alone. Conclusion: The ABR values and number of apoptotic cells did not significantly increase in the group receiving gentamicin plus thymoquinone when compared to the group receiving gentamicin alone. Again, the cochlear histomorphological findings were supportive of the auditory findings. In light of these findings, we conclude that gentamicin-induced ototoxicity may be prevented by thymoquinone use in rats. (C) 2014 Elsevier Inc. All rights reserved.
