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    Bacteriological profile of diabetic foot ulcers and analysis of serum meteorin levels
    (Springer, 2025) Erdogan, Esra; Yetisgen, Azize; Keskin, Lezzan; Tanriverdi, Elif Seren; Ugur, Isilay Gokce Benk
    ObjectiveWith the increase in the incidence of diabetes mellitus (DM) in recent years, diabetic foot ulcers (DFU), which are common and serious chronic complications of diabetes, have also become widespread. DFU is highly associated with a significant deterioration in quality of life as well as increased morbidity and mortality. Meteorin is a potent neurotrophic growth factor and shows antiangiogenic, antihyperalgesic, antinociceptive and neuroprotective effects. This study aimed to determine the possible relationship between meteorin, diabetes and diabetic foot ulcer by comparing the serum meteorin levels of healthy control group, DM patients and patients with diabetic foot ulcers.MethodsOur study included a total of 62 diabetic patients, 31 of whom had DFU, and 29 healthy individuals as a control group. Meteorin levels of the participants were measured using ELISA method in serum samples. Other laboratory and epidemiological data of the patients were obtained from the hospital database.ResultsIn the wound cultures taken from patients with DFU, the most commonly isolated bacteria were Staphylococcus aureus and Pseudomonas aeruginosa. Serum meteorin levels were found to be statistically significantly higher in diabetic patients as compared to the healthy control group, and among diabetic patients, those with DFU had significantly higher levels compared to those without DFU. A positive significant correlation was found between meteorin level and age, HbA1c, WBC, urea, sedimentation, CRP and ferritin.ConclusionThe results of our study, aimed at better understanding the biological functions and potential clinical applications of meteorin, suggest that meteorin could potentially be used as a biomarker for the development of DFU.
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    Comparison of thyroid fine needle aspiration biopsy and ultrasonography results
    (Lippincott Williams & Wilkins, 2023) Keskin, Lezzan; Karahan, Dogu; Yaprak, Buelent
    Thyroid nodules are one of the most common health problems in the community. Although most of the nodules are benign, Fine needle aspiration biopsy (FNAB) is requested due to malignancy concerns. In this research, the aim was to make a comparison of the results of thyroid ultrasonography (USG) and FNAB for thyroid nodules. This study was conducted retrospectively on the data of 532 patients. Detail Edu ultrasonographic assessment was conducted before the FNAB procedure and FNAB was performed by an endocrinology specialist. FNAB results and Thyroid USG features were compared, and thyroid FNAB results were graded using the classification of World Health Organization Bethesda-2017. The average age of the individuals included in the research was 49.99 & PLUSMN; 13.65 (min = 18-max = 97). According to the 2017 Bethesda classification, 74.6% of FNAB results were benign, 16% follicular lesion of undated mined significance or A type of undated mined significance, 0.9% were malignant, and 1.1% were suspicious for malignancy. When USG findings were compared according to FNAB results, it was found that malignant lesions were significantly higher in single nodules (non- cystic and non- mixed lesions). Lesions with a single nodule on USG were found to be 3.6 times more likely to be malignant (OR 95% CI: 1.172-11.352). The gold standard method for the diagnosis the presence of thyroid nodules is thyroid fine needle aspiration biopsy with ultrasound guidance. Taking samples from the correct nodule and component increases its value. The presence of a single nodule from the thyroid USG features was found to be an important predictor of malignancy according to the biopsy results.
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    THE RELATIONSHIP BETWEEN GLYCAEMIC INDEX, DAILY ENERGY INTAKE, METABOLIC PARAMETERS, AND BODY COMPOSITION IN THE ELDERLY: A CROSS-SECTIONAL STUDY
    (Gunes Kitabevi Ltd Sti, 2022) Mete, Burak; Keskin, Lezzan
    Introduction: This study aimed to evaluate the relationship between dietary glycaemic index, daily energy intake, metabolic parameters and body composition in elderly individuals.Materials and Methods: This is a cross-sectional study that included 198 elderly individuals who applied to the endocrinology outpatient clinic. Participants were asked to record the foods they consumed on three-day diet forms, which would be collected the following week at the time when also the metabolic parameters would be measured and body composition analyses performed at the polyclinic. Nutrient content was recorded with the BeBIS software. The body composition was analysed by using the bioelectrical impedance method.Results: The mean age of 198 people included in the study was 67.78 +/- 2.76 (65-78). HbA1c, insulin and HOMA-IR, visceral adiposity rates, body fat mass and metabolic age were found to be higher in participants with a dietary glycaemic index >= 70, and the effect of the glycaemic index on these parameters was statistically small. The daily energy intake showed a positive correlation with fasting blood glucose, triglyceride and triglyceride-glucose (TyG) index. Both the daily energy intake and glycaemic index showed a weakly positive correlation with visceral adiposity, metabolic age, body fat mass and body mass index. A dietary glycaemic index >= 70 was observed to increase the risk of obesity OR=3.7 times (95% CI=1.72 - 7.94), and the risk of HbA1C higher than 8 to increase OR=3.13 times (95% CI=1.0 - 9.74).Conclusion: An increase in the dietary glycaemic index and the daily energy intake in the elderly results in poor glycaemic control.