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Öğe Development of lidocaine-containing modified pleural talc structures as antibacterial drug delivery systems to prevent pleural effusion or pneumothorax(Springer, 2025) Ozhan, Onural; Koytepe, Suleyman; Ates, Burhan; Acari, Idil Karaca; Gurses, Canbolat; Parlakpinar, HakanPleurodesis is a common practice to close the pleural space and to treat persistent pneumothorax to prevent recurrent pleural effusion. When the patient has pleurodesis, the pleural fluid is drained first and then talc is applied to the pleural space. The talc application process consists of directly depositing the talc structure with the appropriate particle size into the relevant space. Both the space is filled and the patient's lung movement comfort is provided during the breathing process due to the slippery effect of the talc structure. Otherwise, the patient experiences a very painful process during the breathing process. However, some important indications can be observed both during and after the talc deposition. At the beginning of these indications is the formation of infection and innovative practices are very significant in eliminating such an infection. In order to prevent infection during talc process, intensive antibiotic application is made before and after the application. In this study, more effective and innovative talc structures were developed and the talc structure was modified with a zwitter ionic polymeric coating to prevent infection. A surface modification was carried out by attaching 3-vinylpropyl-triethoxysilane binding agent on the appropriately sized talc structures. The functionalized talc structure was transformed into a surface that would work with the kill and release principle. The structure of 2-(tert-butylamino)ethyl methacrylate was modified for this process. A quaternary ammonium structure was formed on the talc surface thereby, bacteria will be killed and then, removed from the surface. In the research, local anesthesic agent lidocaine was also loaded to provide convenience to the patient. Structural characterizations of the obtained structures were performed by Fourier Transform Infrared Spectrophotometer (FTIR). Its thermal properties were determined by thermogravimetric analysis (TGA), differential thermal analysis (DTA) and differential scanning calorimetry (DSC) techniques. Moreover, the antibacterial properties of the obtained structures were examined.Öğe Development of microbial chondroitin sulfate-based proton exchange membranes for microbial fuel cells(Elsevier Sci Ltd, 2024) Erenler, Sebnem A.; Unver, Tuba; Ozaslan, Bahar F.; Koytepe, Suleyman; Sezer, SeldaTechnological developments have led to a significant increase in energy demand, and thus the interest in alternative energy has increased in the same direction. For this reason, fossil fuel reserves and climate-based renewable energy sources were used as alternatives in energy production, but the desired success was not fully achieved due to the decrease in fossil fuel and climate changes, and a new alternative energy source was sought. This situation has made Microbial Fuel Cells (MFC), which can directly convert chemical energy, an important alternative to renewable energy, from organic waste into electrical energy with the help of microorganisms. Therefore, in this study, microbially obtainable chondroitin, which is a non-toxic, biocompatible organic molecule that will not disrupt the ecological balance, sulfate-based proton exchange membrane was prepared for the microbial fuel cell. For this, Chondroitin was synthesized by the microbial method, chondroitin sulfate was obtained by sulfation, and chondroitin sulfate membranes were prepared by cross-linking with sulfosuccinic acid at varying molar concentrations (0.2, 0.4, 0.6, and 0.8). Firstly, the structural characterization, thermal properties, and morphological features of the prepared 20 mm thickness membranes were investigated, and then the effects of parameters such as pH change, voltage, quaternization, internal resistance, and coulomb efficiency on microbial fuel cell performance were studied. The best result was found to be that of chondroitin sulfate cross-linked with 0.8 M sulfosuccinic acid, which had an internal resistance of 0.310 omega, a power density of 30 mW/m2, and a coulomb efficiency of 70 %. Additionally, proton conductivity was measured to be 0.9919 mS/ cm, and thanks to the proton conduction efficiency of the designed Microbial chondroitin sulfate membranes, it has been determined that it has an effective proton exchange membrane potential. These developments show that microbial chondroitin sulfate-based membranes may be an alternative candidate for microbial fuel cells.Öğe Effects of Yttrium Doping on Erbium-Based Hydroxyapatites: Theoretical and Experimental Study(Mdpi, 2022) Ahmed, Lana Omar; Bulut, Niyazi; Kebiroglu, Hanifi; Alkhedher, Mohammad; Ates, Tankut; Koytepe, Suleyman; El Din, ElSayed M. TagThis is the first investigation of yttrium (Y) and erbium (Er) co-doped hydroxyapatite (HAp) structures, conducted using theoretical and experimental procedures. By using a wet chemical method, the materials were synthesized by varying the concentration of Y amounts of 0.13, 0.26, 0.39, 0.52, 0.65, and 0.78 at.% every virtual 10 atoms of calcium, whereas Er was kept fixed at 0.39 at.%. Spectroscopic, thermal, and in vitro biocompatibility testing were performed on the generated samples. Theoretical calculations were carried out to compute the energy bandgap, density of states, and linear absorption coefficient. The effects of Y concentration on thermal, morphological, and structural parameters were investigated in detail. Raman and Infrared (FTIR) spectroscopies confirmed the formation of the HAp structure in the samples. Theoretical investigations indicated that the increasing amount of Y increased the density from 3.1724 g cm(-3) to 3.1824 g cm(-3) and decreased the bandgap energy from 4.196 eV to 4.156 eV, except for the sample containing 0.39 at. % of the dopant, which exhibited a decrease in the bandgap. The values of linear absorption appeared reduced with an increase in photon energy. The samples exhibited cell viability higher than 110%, which revealed excellent biocompatibility for biological applications of the prepared samples.Öğe Efficacy of Modified Talc Powder in Experimental Rat Model of Pleurodesis(Mdpi, 2026) Kilic, Murat; Ozhan, Onural; Yildiz, Azibe; Koytepe, Suleyman; Akyuz, Mustafa; Turkoz, Yusuf; Parlakpinar, HakanBackground: Pleurodesis is a treatment method that aims to create permanent adhesion between the pleural layers to prevent recurrent fluid or air accumulation in the pleural cavity. Talc, one of the most commonly preferred agents in this procedure, is widely used in clinical practice. In this study, a new talc formulation with a modified surface to impart antibacterial and analgesic properties was experimentally evaluated for the first time. The main objective of the study was to comparatively assess the inflammatory and fibrotic responses following standard talc and modified talc applications. Methods: Thirty-six 12-week-old female Wistar albino rats were simply randomly divided into three different groups: control (n = 12), standard talc (n = 12), and modified talc (n = 12). Under anesthesia, 1 mL of physiological saline containing 17 mg of talc was injected intrapleurally into the right hemithorax. The presence of pneumothorax after the procedure was assessed by chest radiography. After a 12-day follow-up period, the animals were euthanized. Bronchoalveolar lavage (BAL) fluid samples, blood samples, and lung and pleural tissue samples were collected for biochemical, histopathological, and immunohistochemical analyses. Results: Modified talc application resulted in a significant increase in both visceral and parietal pleural thickness (p < 0.05). Granulation tissue formation and collagen deposition were significantly higher in the modified talc group. In addition, TGF-beta expression and CD68-positive macrophage count increased significantly in the modified talc group (p < 0.05). Inflammatory changes in the lung parenchyma were limited and not statistically significant. Conclusions: The modified talc formulation enriched with lidocaine and antibacterial agents produced a stronger inflammatory and fibrotic response compared to standard talc. These findings indicate that modified talc may increase the effectiveness of pleurodesis. Furthermore, the absence of significant lung parenchymal damage suggests that this treatment is locally effective and feasible. However, further long-term and advanced studies are needed to translate these results into clinical use.Öğe Experimental and theoretical characterization of Bi-based hydroxyapatites doped with Ce(Elsevier Sci Ltd, 2022) Kareem, Rebaz Obaid; Kaygili, Omer; Ates, Tankut; Bulut, Niyazi; Koytepe, Suleyman; Kurucay, Ali; Ercan, IsmailThis study deals with the theoretical and experimental characterizations of Bi-based hydroxyapatites (HAps) codoped with Ce. Five samples of Bi-based HAp (at a constant amount of 0.125 at.%) with additions of the Ce in various amounts (0, 0.125, 0.25, 0.375, and 0.500 at. %) were synthesized by using the wet chemical method. The prepared samples were investigated experimentally by X-ray diffraction (XRD), scanning electron microscopy (SEM), Fourier transform infrared (FTIR) spectroscopy, Raman spectroscopy, differential thermal analysis (DTA), thermogravimetric analysis (TGA), and vibrating sample magnetometer (VSM). All the samples were also modeled by using a density functional theory (DFT), and theoretical results were obtained. Both experimental and theoretical results showed that the lattice parameters and unit cell volume were significantly affected by Ce content. Calculated bandgap energy results of the samples gradually reduced from 4.6308 eV to 4.5299 eV. The bandgap decreased with increasing Ce content, and the densities of states (DOS) values were also affected by the amount of Ce. It was found that the sample doped with 0.500 at. % Ce showed the best biocompatibility among all the as-synthesized samples. The linear absorption coefficient increased with increasing amounts of Ce in all samples, while this parameter decreased with increasing photon energy. The density increases with the increasing Ce content ranging from 3.1615 g cm-3 to 3.1772 g cm- 3. Both crystallite size and crystallinity decreased gradually with the increasing amount of Ce. FTIR and Raman spectra confirm the formation of the HAp structure for all the samples.Öğe Ni Katkısının Fe2O3’ün Yapısal Özellikleri Üzerine Etkilerinin Araştırılması(2021) Ates, Tankut; Koytepe, Suleyman; BULUT, NİYAZİ; KAYGILI, OMERSunulan çalışmada, Ni katkısının yaş kimyasal yöntemle hazırlanan Fe2O3’ün yapısal özellikleri üzerine etkileri X-ışını kırınımı (XRD), Fourier dönüşümlü kızılötesi (FTIR), diferansiyel termal analiz (DTA), termogravimetrik analiz (TGA) ve taramalı elektron mikroskopisi (SEM) teknikleri kullanılarak araştırıldı. XRD ve FTIR sonuçları her bir numune için Fe2O3 yapının oluşumunu destekledi. 4at.%Ni katkısına kadar yeni bir faz oluşumu gözlenmedi ve bu numune için NiO ikincil fazının oluşumu tespit edildi. Kristal yapı ilişkili parametreler ve morfoloji, Ni içeriğinden etkilendi. Özetle Ni, Fe2O3 yapının bazı özelliklerini kontrol etmek için kullanılabilir.Öğe Sr/Smco-doped hydroxyapatites: experimental characterization and theoretical research(Springer, 2022) Hssain, Ala Hamd; Bulut, Niyazi; Ates, Tankut; Koytepe, Suleyman; Kurucay, Ali; Kebiroglu, Hanifi; Kaygili, OmerThis paper goes into extensive detail about the theoretical and experimental characterization of Sr doped hydroxyapatite (HAp) samples that have been doped with Sm in various amounts. To accomplish this, five HAps containing a constant 0.133at.% of Sr were additionally doped with Sm at varied amounts and synthesized by a method of wet chemical. In addition, the density functional theory (DFT) was used to model all of these samples. According to theoretical results, the bandgap energy declined continuously from 4.6297 to 4.4034eV. The linear absorption coefficient increased with increasing amounts of Sm in all samples, while this parameter decreased with increasing photon energy. There was a reduction in both the lattice parameter a and the volume of the unit cell, but there was also an increase in the lattice parameter c and theoretical density. Accordingly, the experiment's results were as follows:HAp phase (above 98% for all of the samples) and beta-tricalcium phosphate beta - TCP were both confirmed as the major phase and minor phase, respectively, by X-ray diffraction (XRD), FT-Raman spectroscopy and the Fourier transform infrared (FTIR) measurements. The addition of Sm increased in the beta - TCP phase from 0.62 to 0.86%. Same as theoretical results, it was also found that density was increasing and the volume of the unit cell decreased. An increase in anisotropic energy density and a decrease in crystallinity were discovered. The values are calculated based on the molar ratio, which was discovered to be close to those for stoichiometric HAp in all samples (1.67). Based on the results of the thermal study, all samples were confirmed to be thermally stable. Sm content was discovered to have an effect on cell viability.Öğe Synthesis of Gum Arabic-Based Biopolymer Network and Determination of Its Toxicity Properties in In Vitro - In Vivo Model Systems(2024) AÇARI, İDİL KARACA; TURHAN, DUYGU OZHAN; KURUÇAY, Ali; Koytepe, Suleyman; Ates, BurhanIn this study, gum arabic based network polymers were prepared using epoxy functional PEG structures. The basic physicochemical properties of these structures, their structural characterization, thermal properties and morphological properties were investigated. Toxicity properties of constructs synthesized on zebrafish (Danio rerio (Hamilton)) offspring were determined in vivo. In addition, in vitro toxicity tests were performed on L929 fibroblast cells. When the general properties of these structures were examined. Structural and thermal properties were better with increasing cross-linker rates ratios (1%, 3%, 5%). According to the toxicity test performed on zebrafish juveniles; GA-PEG-Epox (1%) constructs are non-toxic to zebrafish juveniles. The mortality rate of GA-PEG-Epox (3%) and GA-PEG-Epox (5%) structures was observed as 12.5% and 20.8%, respectively. It was observed that the structures were not toxic to zebrafish juveniles. MTT test performed on L929 fibroblast cells, high cell viability (>90%) was observed in all synthesized structures. These results are evaluated as Grade 1 according to ISO standards.Öğe The experimental and theoretical investigation of Sm/Mg co-doped hydroxyapatites(Elsevier, 2022) Hssain, Ala Hamd; Bulut, Niyazi; Ates, Tankut; Koytepe, Suleyman; Kurucay, Ali; Kebiroglu, Hanifi; Kaygili, OmerThis study presents an extensive experimental and theoretical analysis of Mg -doped hydroxyapatite (HAp) samples with additional Sm doping at varying amounts. A wet chemical method was used to synthesize Mg-containing HAps at a constant amount of 0.133 at. %, and in addition the second dopant of Sm was utilized at varying amounts of 0.133, 0.266, 0.399, 0.532, and 0.665 at. %. All of these samples were investigated experimentally and theoretically by using the X-ray diffraction (XRD) analysis, Fourier transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM), Raman spectroscopy, differential thermal analysis (DTA), thermogravimetric analysis (TGA), in-vitro cell viability tests, and density functional theory (DFT) calculations. The bandgap energy was found to have reduced from 4.6115 eV to 4.3870 eV. The linear attenuation (or absorption) coefficient increased as the amount of Sm in the sample increased, and this parameter decreased as the photon energy increased for all samples. Both the lattice parameter and the theoretical density increased, whereas the unit cell volume and the lattice parameters declined. The XRD and FTIR results revealed that the HAp phase (over 98 percent for all samples) was a major phase formed, while the beta -TCP phase (beta-tricalcium phosphate) was a minor phase. The beta-TCP phase increased from 0.91 to 1.57 percent with an increasing amount of Sm. The volume of the unit cell trended in the same direction as predicted by the obtained results theoretically. Increased anisotropic energy density and a decrease in crystallinity have been observed. All samples were found to be thermally stable. Due to the presence of Sm content, cell viability was observed to be affected.Öğe Theoretical and experimental investigation of structural, spectroscopic, and thermal properties of Bismuth- and Gadolinium-doped hydroxyapatites(Elsevier, 2026) Ates, Tankut; Acar, Emine Nur; Barzinjy, Azeez A.; Koytepe, Suleyman; Keser, Serhat; Adam, Ibrahim Muhammad; Kaygili, OmerIn this study, hydroxyapatite (HAp) materials doped with bismuth (Bi) and gadolinium (Gd) were synthesized using the wet chemical precipitation method and comprehensively characterized through both theoretical and experimental approaches. Density functional theory (DFT) calculations were employed to investigate the effects of co-doping with Bi and Gd on the electronic structure, lattice parameters, and unit cell volume. Results revealed a consistent reduction in bandgap energy with increasing dopant concentration, highlighting the tunability of HAp's electronic properties for advanced functional applications. Structural analyses revealed subtle reductions in lattice constants and unit cell volume, confirming the incorporation of dopants and lattice contraction. Experimental characterizations included X-ray diffraction (XRD), Fourier-transform infrared (FTIR) and Raman spectroscopy, thermal analyses (DTA/TGA), scanning electron microscopy (SEM), and energy-dispersive X-ray spectroscopy (EDX). XRD confirmed phase purity with minor beta-TCP formation, while FTIR and Raman spectra validated the presence of phosphate and hydroxyl groups typical of HAp. Thermal analyses indicated excellent stability up to 900 degrees C with minimal mass loss, especially in doped samples. SEM images revealed nanostructured spherical morphologies with homogenous elemental distribution, while EDX confirmed the successful integration of Bi and Gd into the HAp lattice. Biocompatibility assays using l-929 fibroblast cells showed high cell viability (>80%) for all samples, indicating excellent biocompatibility with negligible cytotoxicity. Notably, Gd-doped and co-doped samples showed improved biological responses. These findings suggest that Bi/Gd co-doped HAp materials hold strong potential for biomedical applications such as bone implants and dental restorations, where enhanced electronic, thermal, and biocompatibility properties are crucial.Öğe Zinc Sulfur Nanoparticles Cause Both the Negatory Vitality and Bioaccumulation on Gammarus pulex(Springer, 2025) Ozgur, Mustafa Erkan; Maras, Zeynep; Aydemir, Songul; Acari, Idil Karaca; Erdogan, Selim; Charles, Sandrine; Koytepe, SuleymanIn recent years, Zinc Sulphur Nanoparticles (ZnS-NPs) have a wide range of applications such as in optical sensor, solid state solar window layers, photoconductors, phosphors and catalysts. There are no clear data on the waste-enriching effects of this nanoparticle, whose annual consumption is over million tons, and concerns remain unanswered. This research was also designed to investigate lethal and sublethal toxicity, as well as survivability and bioaccumulation on Gammarus pulex for the effects of possible waste products of ZnS-NPs. After acute 96-hours experiments, while the lethal concentration (LC50) value was estimated at 3.39 (2.79-4.17) ppm, it was found that both the toxicity and the accumulation levels of ZnS-NPs in tissues increased with increasing exposure durations and doses. Statistically significant differences were observed in ventilation rates of the organisms as exposure durations increased at higher doses such as 2, 5, and 10 ppm. According to our results, the lowest ventilation rate was determined at the highest dose of ZnS-NPs. Moreover, ZnS-NPs was proved to be highly toxic after 3.5 ppm, while ZnS-NPs very slowly accumulate in Gammarus pulex tissues (BCF equal to 5.8.10- 4 (4.28.10- 4; 7.2.10- 4) at the highest exposure dose).
