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    Atopic Features and Inflammatory Markers Across Cassano-Graded Adenoid Hypertrophy
    (Mdpi, 2026) Kaplan, Fatih; Kurnaz Kaplan, Bilge; Gulyuz, Abdulgani
    Highlights What are the main findings? center dot In children with adenoid hypertrophy, disease severity was independently associated with eosinophilia rather than with IgE-mediated sensitization. center dot Family history of atopy and elevated total IgE were the strongest factors associated with clinical atopy. What is the implication of the main finding? center dot Inflammatory burden may play a more important role than classical allergic sensitization in determining adenoid hypertrophy severity. center dot Evaluation of eosinophilia may provide additional clinical information in the routine assessment of children with adenoid hypertrophy.Highlights What are the main findings? center dot In children with adenoid hypertrophy, disease severity was independently associated with eosinophilia rather than with IgE-mediated sensitization. center dot Family history of atopy and elevated total IgE were the strongest factors associated with clinical atopy. What is the implication of the main finding? center dot Inflammatory burden may play a more important role than classical allergic sensitization in determining adenoid hypertrophy severity. center dot Evaluation of eosinophilia may provide additional clinical information in the routine assessment of children with adenoid hypertrophy.Highlights What are the main findings? center dot In children with adenoid hypertrophy, disease severity was independently associated with eosinophilia rather than with IgE-mediated sensitization. center dot Family history of atopy and elevated total IgE were the strongest factors associated with clinical atopy. What is the implication of the main finding? center dot Inflammatory burden may play a more important role than classical allergic sensitization in determining adenoid hypertrophy severity. center dot Evaluation of eosinophilia may provide additional clinical information in the routine assessment of children with adenoid hypertrophy.Highlights What are the main findings? center dot In children with adenoid hypertrophy, disease severity was independently associated with eosinophilia rather than with IgE-mediated sensitization. center dot Family history of atopy and elevated total IgE were the strongest factors associated with clinical atopy. What is the implication of the main finding? center dot Inflammatory burden may play a more important role than classical allergic sensitization in determining adenoid hypertrophy severity. center dot Evaluation of eosinophilia may provide additional clinical information in the routine assessment of children with adenoid hypertrophy.Abstract Background: Evidence linking adenoid hypertrophy (AH) and atopy is conflicting. We examined whether Cassano-graded AH severity is more closely associated with inflammatory markers than with IgE-mediated sensitization. Methods: We retrospectively included children aged 3-12 years diagnosed with AH between December 2022 and December 2025. AH was graded according to the Cassano classification and dichotomized as advanced AH (Stage III-IV). Atopic features were evaluated separately as clinical atopy, IgE-mediated sensitization, elevated total IgE, and eosinophilia. Multivariable logistic regression analyses were performed to assess factors associated with clinical atopy, sensitization, and advanced AH. Results: Among 426 children, clinical atopy was present in 28.2%, sensitization in 23.0%, elevated total IgE in 16.4%, and eosinophilia in 27.7%; 39.2% had advanced AH. In multivariable analysis, clinical atopy was independently associated with family history of atopy (aOR 13.9; 95% CI 7.9-24.4), elevated total IgE (aOR 3.86; 95% CI 2.10-7. 08), and passive smoking exposure (aOR 1.73; 95% CI 1.07-2.79). Sensitization was independently associated only with family history of atopy (aOR 4.99; 95% CI 1.99-12.53). Advanced AH was independently associated only with eosinophilia (aOR 2.07; 95% CI 1.30-3.29). Conclusions: AH severity was associated with eosinophilia rather than classical IgE-mediated sensitization. Assessment of eosinophilia may aid routine severity evaluation in children with AH.
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    Clinical Implications of Post-Earthquake Environmental Exposures in Children with Allergic Diseases
    (Mdpi, 2026) Kaplan, Fatih; Kurnaz Kaplan, Bilge; Arikanoglu, Emrullah; Gulyuz, Abdulgani
    Highlights What are the main findings? Post-earthquake environmental exposures were associated with worsening disease control in children with allergic diseases. Prolonged residence in temporary housing and exposure to demolition-related dust were independently associated with clinical deterioration, particularly among children with asthma. What are the implications of the main findings? Children with chronic allergic diseases should be considered a vulnerable population in post-disaster settings. Dust-control measures, air-quality monitoring, and improved living conditions in temporary housing may help reduce post-disaster worsening of allergic diseases.Highlights What are the main findings? Post-earthquake environmental exposures were associated with worsening disease control in children with allergic diseases. Prolonged residence in temporary housing and exposure to demolition-related dust were independently associated with clinical deterioration, particularly among children with asthma. What are the implications of the main findings? Children with chronic allergic diseases should be considered a vulnerable population in post-disaster settings. Dust-control measures, air-quality monitoring, and improved living conditions in temporary housing may help reduce post-disaster worsening of allergic diseases.Abstract Background/Objectives: Environmental changes following large-scale natural disasters may influence the clinical course of chronic diseases. However, the impact of post-earthquake environmental exposures on pediatric allergic diseases remains insufficiently studied. To evaluate the association between post-earthquake environmental exposures and disease control in children with allergic diseases. Methods: This retrospective longitudinal cohort study included 528 children with previously diagnosed asthma, allergic rhinitis, or atopic dermatitis who were followed in a tertiary pediatric allergy center in Malatya, T & uuml;rkiye. Clinical assessments performed before the 6 February 2023 Kahramanmara & scedil; earthquakes (T0) were compared with follow-up evaluations conducted 6-12 months after the earthquake (T1). Environmental exposures assessed during the post-earthquake period included prolonged residence in temporary housing, demolition-related dust exposure, and elevated ambient particulate matter levels. Clinical deterioration was defined using disease-specific indicators (decline in ACT/cACT score or treatment step escalation for asthma, increase in TNSS for allergic rhinitis, and increase in SCORAD for atopic dermatitis). Multivariable logistic and linear regression models were used to evaluate associations between environmental exposures and clinical outcomes. Results: Clinical deterioration was observed in 219 children (41.5%). Prolonged residence in temporary housing for >= 6 months (aOR 2.1, 95% CI 1.2-3.9, p = 0.01) and exposure to demolition-related dust (aOR 1.9, 95% CI 1.1-3.5, p = 0.02) were independently associated with clinical deterioration. Among children with asthma, both prolonged temporary housing (adjusted beta -1.84, p = 0.002) and demolition-related dust exposure (adjusted beta -1.39, p = 0.018) were associated with worsening asthma control. Conclusions: Post-earthquake environmental exposures, particularly prolonged residence in temporary housing and demolition-related dust exposure, were associated with worsening control of pediatric allergic diseases. These findings highlight the importance of environmental health considerations in disaster response and long-term management of children with chronic allergic conditions.