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Öğe Coping with stress, psychological resilience and psychiatric symptoms in migraine patients(Bayrakol Medical Publisher, 2023) Emir, Burcu Sirlier; Yildiz, Sevler; Kilicaslan, Asli Kazgan; Dogan, Serpil; Kurt, Osman; Ugur, KerimAim: Migraine is a prevalent chronic disease with unknown etiopathogenesis that affects the quality of life. In the present study, we aimed to investigate anxiety, depression, coping with stress and psychological resilience of migraine patients. Material and Methods: The study was conducted with 40 patients and 40 healthy individuals. The study data were collected with a sociodemographic and clinical data form, Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), Psychological Resilience Scale for Adults (RSA), and Inventory of Coping Strategies (ICS). Results: It was determined that the RSA-structural resilience, RSA-social competence, BDI, BAI, ICS-optimism and ICS-social support scores of the patients were significantly higher when compared to the control group, RSA-self-perception, RSA-future perception, RSA-familial conformity, RSA-social resources, RSA-total and ICS-safe approach scores were significantly lower in the patient group when compared to the controls. There were positive correlations between the number of migraine attacks and RSA-future perception, RSA-familial conformity, RSA-social resources and RSA-total scores of the patients; There was a significant negative correlation between the number of migraine attacks and ICS-optimism scores. Discussion: The incidence of anxiety and depression was significantly higher and psychological resilience was significantly lower in the patients when compared to the control group. It could be suggested that patients could prefer ineffective coping strategies and their psychological resilience could be low. The determination of the psychiatric complications associated with migraine could alter treatment interventions, and thus, the prognosis.Öğe The Correlation Between Serum Uric Acid Level and Certain Clinical Variables in Antisocial Personality Disorder Patients(2021-03-03) Yıldız, Sevler; Kazğan, Aslı; Kurt, Osman; Korkmaz, Sevda; Uğur, KerimObjectives: In this study, we aimed to compare serum uric acid levels in patients diagnosed with antisocial personality disorder with a healthy control group, and also to investigate the relationship between serum uric acid levels and impulsivity and aggressive attitudes. Methods: The study was conducted with 126 individuals (69 with antisocial personality disorder, 57 controls). The Sociodemographic Data Form, the Barratt Impulsivity Scale (BIS-11), and the Buss–DurkeeHostility Inventory (BDHI) were applied to all participants. Venous blood samples were collected from all participants to measure serum uric acid levels. Results: It was determined that both the BIS-11 and the BDHI sub-dimensions, and the total scores of the antisocial personality disorder patients were higher when compared to the healthy control group. The serum uric acid levels of the patient group were significantly higher when compared to those of the control group. Furthermore, there was a significant positive correlation between serum uric acid level and Barratt Impulsivity Scale–11 (r=0.635, P < .001) and Buss–Durkee Hostility Inventory (r=0.572, P < .001) scores. Conclusion: In our study, it was found that serum uric acid levels were higher in patients with antisocial personality disorder, which is characterized by impulsivity and aggressive behavior, when compared to the control group. The findings of the present study suggest that purinergic dysfunction may also play a role in the etiopathogenesis of the disease. Further studies are required to determine whether this was a cause or an outcome.Öğe Evaluation Of Depression, Self-esteem And Hopelessness In Patients Admitted To Psychiatry Outpatient Clinic In Geriatric Population During COVID-19 Outbreak(2021-09-26) Yıldız, Sevler; Kazgan, Aslı; Kurt, Osman; Uğur, KerimInfection control measures taken to ensure social isolation during the COVID-19 pandemic process seem to negatively affect the mental health of elderly individuals. In this study, it is aimed to examine the effects of pandemic on the mental health of the elderly. 150 patients over the age of 65 who were admitted to the psychiatry outpatient clinic for the first time during the pandemic period were included in the study. Socio demographic data form, Geriatric Depression Scale (GDS), Beck Hopelessness Scale (BHS), Rosenberg Self Esteem Scale (RSE) were applied to all cases after the psychiatric interview conducted by us. In the geriatric population, it was observed that there was a significant negative correlation between BHS and RSE (r = -0.241 p = 0.003), and a positive significant relationship between BHS and GDS (r = 0.478 p <0.001). There was no significant correlation between RSE and GHS (r = -0.042 p = 0.614). During the COVID-19 pandemic, it is understood that the hope level and self-esteem of the geriatric population are low, and their mood is depressive. Among the measures to be taken during infection control, we think that elderly people should be given psychosocial support, and thus a healthier environment can be offered to these individuals in terms of physical and mental aspectsÖğe Evaluation of neurological disorders that develop concurrently with COVID-19 pneumonia: a retrospective analysis(Associacao Arquivos de Neuro-Psiquiatria Dr. Oswaldo Lange / Associação Arquivos de Neuropsiquiatria Dr Oswaldo Lange, 2022) Taşçı, İrem; Balgetir, Ferhat; Müngen, Bülent; Demir, Caner Feyzi; Gönen, Murat; Delen, Leman Acun; Kurt, OsmanBackground: During the pandemic, many neurological symptoms have been evaluated as complications of COVID-19 pneumonia. Objective: To investigate the frequency and characteristics of neurological findings, and their effects on the prognosis of patients with COVID-19 pneumonia who consulted with the Neurology department. Methods: Data on 2329 patients who were hospitalized with the diagnosis of COVID-19 pneumonia in our hospital were scanned. The clinical, laboratory and radiological findings relating to treatment of 154 patients who required neurological consultation were retrospectively evaluated by reviewing the clinical notes. Results: The number of COVID-19 pneumonia patients who required neurological consultations while hospitalized in the ICU was 94 (61.0%). The most common symptom among these patients was hyperactive delirium. Mean age, ferritin levels and CRP values ??of those with delirium were higher, while the mean lymphocyte percentage were lower, than those of the patients without delirium. Epileptic seizures were observed in eight patients without an epilepsy diagnosis. Two patients were diagnosed with GBS and one patient with ICU neuropathy. The D-dimer levels of patients with acute hemorrhagic CVD and the thrombocyte levels of patients with acute ischemic CVD were found to be higher than in patients without acute ischemic CVD. Conclusion: The proportion of patients who required neurological consultations was higher in the ICUs. We observed neurological symptoms more frequently in the advanced age group. There were no significant increases in the incidence of other neurological conditions except delirium, in COVID-19 patients. We think that further studies are needed to support our data.Öğe Evaluation of Optical Coherence Tomography Findings in Antisocial Personality Disorder Patients(Aves, 2023) Emir, Burcu Sirlier; Yildiz, Sevler; Kilicaslan, Asli Kazgan; Kurt, Osman; Keser, Sinem; Ugur, KerimBackground: Antisocial personality disorder is a frequently studied personality disorder, and its etiopathogenesis is still investigated. Neuroimaging demonstrated that certain regions of the brain could be associated with this disorder, and in the present study, we aimed to investigate the changes in retina, which could be considered an extension of the brain in antisocial personality disorder patients with optical coherence tomography. Methods: The study was conducted with 35 patients and 35 healthy controls. The study data were collected with the Sociodemographic and Clinical Data Form, Beck Anxiety Inventory, Beck Depression Inventory, and Barratt Impulsivity Scale-Short Form. Retinal nerve fiber layer thickness, choroidal thickness, and macular thickness were analyzed based on optical coherence tomography. Results: The Beck Depression Inventory (P =.044), Beck Anxiety Inventory (P =.005), Barratt Impulsivity Scale-motor (P <.001), Barratt Impulsivity Scale-non-planning dimension (P <.001), and Barratt Impulsivity Scale-total scores (P <.001) of the patients were significantly higher when compared to the controls. The superior (P =.013) and inferior retinal nerve fiber layer thickness (P <.001) of the patients were significantly lower when compared to the control group. Conclusion: Retinal nerve fiber layer thickness was significantly lower in the patient group when compared to healthy controls, which suggested that it could be associated with the pathophysiology of antisocial personality disorder.Öğe Evaluation of Oxidative Stress and Endothelial Dysfunction in COVID-19 Patients(Mdpi, 2024) Berber, Nurcan Kirici; Kurt, Osman; Geckil, Ayseguel Altintop; Erdem, Mehmet; Kiran, Tugba Raika; Otlu, Onder; In, ErdalBackground and Objectives: Heat shock proteins (HSPs) are stress proteins. The endogenous nitric oxide (NO) synthase inhibitor asymmetric dimethyl arginine (ADMA) is a mediator of endothelial dysfunction. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus causes endothelial dysfunction and coagulopathy through severe inflammation and oxidative stress. Using these markers, we analyzed the prognostic value of serum ADMA and HSP-90 levels for early prediction of severe coronavirus disease (COVID-19) patients. Materials and Methods: A total of 76 COVID-19 patients and 35 healthy control subjects were included in this case-control study. COVID-19 patients were divided into two groups: mild and severe. Results: Serum ADMA and HSP-90 levels were significantly higher in the COVID-19 patients compared to the control subjects (p < 0.001). Additionally, serum ADMA and HSP-90 levels were determined to be higher in a statistically significant way in severe COVID-19 compared to mild COVID-19 (p < 0.001). Univariable logistic regression analysis revealed that ADMA and HSP-90, respectively, were independent predictors of severe disease in COVID-19 patients (ADMA (OR = 1.099, 95% CI = 1.048-1.152, p < 0.001) and HSP-90 (OR = 5.296, 95% CI = 1.719-16.316, p = 0.004)). When the cut-off value for ADMA was determined as 208.94 for the prediction of the severity of COVID-19 patients, the sensitivity was 72.9% and the specificity was 100% (AUC = 0.938, 95%CI = 0.858-0.981, p < 0.001). When the cut-off value for HSP-90 was determined as 12.68 for the prediction of the severity of COVID-19 patients, the sensitivity was 88.1% and the specificity was 100% (AUC = 0.975, 95% CI= 0.910-0.997, p < 0.001). Conclusions: Increased levels of Heat shock proteins-90 (HSP-90) and ADMA were positively correlated with increased endothelial damage in COVID-19 patients, suggesting that treatments focused on preventing and improving endothelial dysfunction could significantly improve the outcomes and reduce the mortality rate of COVID-19. ADMA and HSP-90 might be simple, useful, and prognostic biomarkers that can be utilized to predict patients who are at high risk of severe disease due to COVID-19.Öğe Examination of alexithymia, psychological resilience and psychiatric symptoms in patients with persistent complex bereavement disorder(Malatya Turgut Özal Üniversitesi, 2022) Emir, Burcu Sırlıer; Yıldız, Sevler; Kılıçaslan, Aslı Kazğan; Uğur, Kerim; Kurt, OsmanBackground: The aim of this study is to examine alexithymia, psychological resilience, and sychiatric symptoms in patients with persistent complex bereavement disorder.Materials and Methods: A total of 62 participants were included in the study, 31 subjects diagnosed with PCBD and 31 healthy controls. Participants were administered the socio-demographic data form, Beck Anxiety Inventory (BAI), Beck Depression Inventory (BDI), Resilience Scale for Adults (RSA), Toronto Alexithymia Scale (TAS-20).Results: BAI (p<0.001), BDI (p<0.001), and TAS-20 (p<0.001) scale scores were found to be significantly higher in the patient group than in the control group. All sub-dimensions of the RSA scale total score were found to be significantly lower between both groups (p <0.001). The anxiety, depression, and lexithymia levels of the patients diagnosed with persistent complex bereavement disorder were significantly higher than the control group; psychological resilience levels were found to be significantly lower.Conclusions: We believe that identifying this situation will shape the psychosocial support to be given to individuals in the pathological mourning processÖğe Inflammation Markers in Patients with Bipolar Disorder Who Have Committed Offenses and Their Relationship with Criminal Behavior(Mdpi, 2023) Sirlier Emir, Burcu; Yildiz, Sevler; Kazgan Kilicaslan, Asli; Kurt, Osman; Ugur, Kerim; Tabara, Muhammed Fatih; Aydin, SueleymanBackground and Objectives: This study aimed to examine the function of various inflammation parameters and their interactions in the pathology of Bipolar disorder (BD) and to assess whether they could be biomarkers in the relationship between criminal behavior and BD. Materials and Methods: Overall, 1029 participants, including 343 patients with BD who have committed offenses, 343 nonoffending patients with BD, and 343 healthy controls, were included in this retrospective study. Neutrophil, lymphocyte, monocyte, and platelet counts; high-density lipoprotein (HDL-c) levels; systemic immune-inflammatory index (SII), systemic inflammatory response index (SIRI), neutrophil to high-density lipoprotein ratio (NHR), lymphocyte to high-density lipoprotein ratio (LHR), monocyte to high-density lipoprotein ratio (MHR), platelet to high-density lipoprotein ratio (PHR) were measured. Results: Significant differences were observed between the groups in terms of SII, SIRI, NHR, LHR, MHR, PHR, neutrophil, and monocyte values (p < 0.001). The lymphocyte counts were significantly higher in the patients with BD who committed offenses (p = 0.04). The platelet counts were significantly lower in the patients with BD who committed offenses compared to nonoffending patients with BD (p = 0.015). The HDL-c levels were significantly lower in the patients with BD who have committed offenses than those of nonoffending patients with BD (p < 0.001). Bipolar disorder, not receiving active psychiatric treatment, having a diagnosis of bipolar manic episodes, and having low platelet and HDL values constitute a risk of involvement in crime. Conclusions: The present study emphasizes the role of systemic inflammation in the pathophysiology of patients with BD with and without criminal offenses and the relationship between inflammation and criminal behavior.Öğe Inflammation markers in patients with psychotic disorder who have committed offenses and their relationship with criminal behavior(Routledge Journals, Taylor & Francis Ltd, 2025) Yildiz, Sevler; Emir, Burcu Sirlier; Kilicaslan, Asli Kazgan; Kurt, Osman; Ugur, Kerim; Sehlikoglu, Seyma; Atmaca, MuradThe role of inflammation in the etiology of psychotic disorders (PD) is well-established. This study aimed to identify inflammation parameters in patients diagnosed with PD, assess their potential as biomarkers, and examine their relationship with criminal behavior. This retrospective study comprised three groups: 530 patients diagnosed with PD who had committed crimes (offenders with PD), 530 patients with PD who had not committed crimes (non-offenders with PD), and 530 healthy controls, totaling 1,590 participants. Routine hematological tests were used to measure neutrophil, lymphocyte, monocyte, and platelet counts, high-density lipoprotein (HDL), systemic inflammatory response index (SIRI), systemic immune-inflammatory index (SII), and neutrophil/HDL (NHR), lymphocyte/HDL, platelet/HDL (PHR), and monocyte/HDL (MHR) ratios. Offenders with PD exhibited significantly higher levels of SII, SIRI, PHR, NHR, LHR, neutrophils, and monocytes compared to non-offenders with PD and healthy controls (p < 0.001). The criminal group had lower HDL and lymphocyte levels than the remaining two groups (p < 0.001). Among those treated in forensic psychiatry units, patients with two or more treatments showed significantly higher SIRI values compared to those with only one treatment (p = 0.045). Non-offenders with PD had higher platelet values than the remaining two groups (p < 0.001). This study underscores the role of systemic inflammation in the pathophysiology of psychotic disorders through a comparison of patients who have and have not committed crimes, highlighting the relationship between inflammation and lipid metabolism. Further research is required to clarify these findings.Öğe Multidrug-resistant uropathogens in pediatric urinary tract ınfections: a multicenter retrospective trend analysis (2020-2024)(Springer, 2026) Erdogan, Esra; Yetisgen, Azize; Dogan, Serpil; Sinanoglu, Muhammed Selcuk; Kilic, Fedli Emre; Kurt, OsmanLarge-scale public health disruptions, including pandemics and natural disasters, may influence healthcare delivery, pathogen distribution, and antimicrobial resistance (AMR). This retrospective multicenter study evaluated uropathogen profiles and temporal trends in antibacterial resistance among hospitalized pediatric patients with urinary tract infections (UTIs) across periods corresponding to the COVID-19 pandemic, the February 6, 2023 Kahramanmara & scedil; earthquakes, and the post-earthquake phase in heavily affected regions of T & uuml;rkiye. Hospitalized pediatric patients (0-18 years) with culture-confirmed UTIs admitted between January 2020 and December 2024 to three tertiary care hospitals were included. Pathogen identification and antibacterial susceptibility testing were performed using standard microbiological methods in accordance with EUCAST criteria. Uropathogen distribution and resistance patterns were compared across predefined study periods. A total of 1131 pediatric patients were analyzed, of whom 54.29% were female. Gram-negative bacteria predominated (89.57%), with Escherichia coli (59.86%) and Klebsiella spp. (18.92%) being the most frequently isolated pathogens. Across the study periods, E. coli demonstrated significant increases in resistance to ampicillin (63.26% to 81.90%), ceftriaxone (41.99% to 53.76%), ceftazidime (39.46% to 63.10%), and trimethoprim-sulfamethoxazole (32.27% to 40.34%) (all p < 0.01). Among Klebsiella spp., a significant temporal increase was observed only for imipenem resistance, which rose from 18.64% during the COVID-19 period to 37.50% during the earthquake period before declining to 13.21% in the post-earthquake period (p = 0.021). Multidrug-resistant (MDR) phenotypes were predominantly detected among Gram-negative organisms, with the highest proportions observed in Serratia spp., Citrobacter spp., Enterobacter spp., and Pseudomonas spp., while MDR prevalence in E. coli was comparatively lower. Temporal variations in antibacterial resistance were observed among pediatric UTI pathogens during periods of major public health disruption. These findings highlight the importance of sustained regional surveillance and context-aware empiric treatment strategies in settings exposed to systemic healthcare stressors.Öğe Premenstrual disforik bozukluk tanılı hastaların kişilik özellikleri, anksiyete duyarlılığı, anksiyete ve depresyon seviyeleri(ÇUKUROVA ÜNİVERSİTESİ, 2021-09-17) Yıldız, Sevler; Kazğan, Aslı; Kurt, Osman; Uğur, Kerim; Atmaca, MuradAmaç: Bu çalışmada Premenstrual disforik bozukluk (PMDB), tanılı hastaların kişilik özelliklerini, anksiyete duyarlılığını, anksiyete ve depresyon düzeylerini değerlendirmeyi amaçlanmıştır. Gereç ve Yöntem: Çalışmaya, PMDB tanısı olan ve psikiyatrik tedavi öyküsü olmayan 40 hasta ve yine hasta grubuyla benzer sosyodemografik özelliklere sahip sistemik ve psikiyatrik hastalık öyküsü olmayan 40 sağlıklı kadın dahil edildi. Tüm katılımcılara Anksiyete-Duyarlılıkİndeksi-3 (ADİ-3), Beck Anksiyete Ölçeği (BAÖ), Beck Depresyon Ölçeği (BDÖ) ve Gözden Geçirilmiş Eysenck Kişilik Anketi-Kısaltılmış Formu (EKA-GGK) uygulandı. Bulgular: Hasta grubunun EKA-GGK nörotisizm, psikotizm, yalan alt ölçekleri ve toplam puanı kontrol grubunun puanından yüksek saptandı. Hasta grubunun ADİ-3 fiziksel, bilişsel, sosyal alt boyutları ve toplam puanı kontrol grubunun puanından yüksek olarak saptandı. PMDB tanılı hastaların BDÖ ile BAÖ ölçek puanı kontrol grubunun puanından yüksek bulundu. Sonuç: Anksiyete duyarlılığı yüksek olan, psikotizm ve nevrotik kişilik özelliklerine sahip kadınlarda bu durum PMDB gelişimini ya da hastalığın seyrini etkileyebilir.
