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Recommendations for Hepatitis B Immunoglobulin and Antiviral Prophylaxis Against Hepatitis B Recurrence After Liver Transplantation
(Murat Aladag, 2021) Mesut Akarsu; Soner Onem; Ilker Turan; Gupse Adali; Meral Akdogan; Murat Akyildiz; Murat Aladag; Yasemin Balaban; Nilay Danis; Murat Dayangac; Genco Gencdal; Hale Gokcan; Elif Sertesen; Merve Gurakar; Murat Harputluoglu; Gokhan Kabacam; Sedat Karademir; Murat Kiyici; Ramazan Idilman; Zeki Karasu
The combination of hepatitis B immunoglobulin and potent nucleos(t)ide analogs after liver transplantation is considered as the standard of care for prophylaxis against hepatitis B virus recurrence. However, the recommended doses, route of administration, and duration of HBIG administration remain unclear. Moreover, hepatitis B immunoglobulin-free prophylaxis with potent nucleos(t)ide analogs has shown promising disease outcomes in preventing hepatitis B virus recurrence. The current recommendations, produced by the Turkish Association for the Study of the Liver, Acute Liver Failure and Liver Transplantation Special Interest Group, suggest a reduced need for hepatitis B immunoglobulin administration with effective long-term suppression of hepatitis B virus replication using potent nucleos(t) ide analogs after liver transplantation.