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Öğe CRANIUMDA BULUNAN SUTURLARIN MORFOMETRİK OLARAK DEĞERLENDİRİLMESİ(2023) Uzun, Gökçe Bağcı; Nisari, MehtapSuturaların erken kaynaşması kraniyosinostoz olarak adlandırılır. Çalışmamızda kafatasında ölçümler yapılarak, cerrahi operasyonlarda ameliyat yerinin tespit edilmesine yardımcı olmak ve literatüre katkı sağlanmak amaçlandı. Erciyes Üniversitesi Tıp Fakültesi Anatomi Anabilim dalında yer alan 22 adet kafatası dijital kumpas ve mezura kullanılarak ölçümler yapıldı. Ölçülen parametereler sırasıyla: Sutura coronalis uzunluğu (SCU),Sutura sagittalis uzunluğu (SSU), Sutura lamboidea uzunluğu (SLU),Sağ-sol asterion arası mesafe (AAM), Sutura coronalis orta noktası (Bregma) – Sutura nasalis (Nasion) arası mesafe (BN), Nasion-Lambda arası mesafe (NLM), Nasion- İniondan geçen baş çevresi (NİBC), Lambda- İnion arası uzunluk (LİU), Pterion-Asterion arası Uzunluk (PAU), Asterion-İnion arası Uzunluk (AİU), Asterion- Prosesssus mastoideus arası mesafe (APM), Pterion- Prosesssus mastoideus arası mesafe (PMU), Pterion- İnion arası mesafe (PİM)’dir. Bu veriler IBM SPSS istatistik yazılımı (versiyon 15.0) kullanılarak hesaplama yapılmıştır. Yapılan ölçümlerimiz; PAU: 94.23±8.0-95.59±8.94 mm, AİU 71.97±9.85-67.55±8.42 mm, APM: 52.96±8.58-52.99± 9.19 mm, PMU: 86.68±11.37- 87.18±12.40 mm, PİM: 130.04±10.63-128.93±15.60 mm, SCU: 120.22±5.29 mm, SSU: 112.67± 8.71 mm, SLU: 153.95±26.18 mm, AAM: 106.91±14.19 mm, BN: 118.71± 19.44 mm, NLM: 162.16±15.12 mm, LİU:65.63±19.00, NİBC: 49.09± 1.37 cm olarak hesaplanmıştır. Sonuç olarak, elde ettiğimiz cranium’a ait bu indeks değerlerinin beyin cerrahisinde klinisyenlere ve literatüre katkı sağlayacağını düşünmekteyiz.Öğe DTI Measurements for Huntington Disease Using Mricloud(2024) ARSLAN, Ayla; Nisari, Mehtap; Guler, Emel; Uzun, Gökçe Bağcı; GULTEKIN, MURAT; donmez, halil; BAGCI, KEZIBANAim: Neurodegenerative diseases are important health problems that affect many people. In this study, it was aimed to examine the brain regions of Huntington's patients by performing brain parcellation. Material and Method: 8 controls and 8 Huntington's patients participated in the study. We measured four Diffusion Tensor Imaging metrics which were axial diffusivity, mean diffusivity, radial diffusivity and fractional anisotropy performing brain parcellation over Diffusion Tensor Imaging for control and patient groups. We used a full automated data-driven approach to study the whole brain, divided in regions of interest using mricloud. Results: When the huntington disease group compared to control group, We found that mean diffusivity and axial diffusivity increased frontal, parietal, temporal, occipital, corpus callosum, white matter, limbic and subcortical structures, and radial diffusivity increased corpus callosum, capsula interna (p<0.05). The fractional anisotropy value was higher in nucleus caudatus, putamen and a significant difference was observed (p<0.05). Conclusion: The increase of axial diffusivity and mean diffusivity values axonal degeneration and demyelination of frontal, parietal, temporal, occipital, corpus callosum, white matter, limbic, subcortical structures; increased radial diffusivity values dysmyelination of the corpus callosum and capsula interna; fractional anisotropy increased values in nucleus caudatus and putamen may indicate a degenerative process, axon loss and inflammation.Öğe Effect of carnosine on ovarian follicle in rats exposed to electromagnetic field(Soc Anatomica Espanola, 2022) Arslan, Ayla; Balcioglu, Esra; Nisari, Mehtap; Yalcin, Betul; Ulger, Menekse; Guler, Emel; Uzun, Gokce BagciThe electromagnetic field (EMF) has an effect on various organs, including the female reproductive system. The purpose of this study was to evaluate the impact of carnosine on ovarian follicle number and diameter in rats exposed to a 900 Megahertz (Mhz) electromagnetic field. In this study, six different groups were used. 40 female rats divided into groups were evaluated. The ovaries of the rats were removed at the end of the study. Routine histological procedures were performed on ovarian tissues. Follicle number and diameter of all groups were calculated and evaluated under the light microscope. When primary follicle number and diameters were compared statistically among the groups, there was a remarkably meaningful difference between the EMF group and the control, 20 mg carnosine and EMF+20 mg carnosine groups (p<0.05). There were significant irregularities in the structure of the oocyte and the granulosa cells surrounding the oocyte, especially in the EMF-treated groups. However, the structure of the oocyte and the granulosa cells surrounding the oocyte in the EMF+20 mg carnosine group showed a more regular structure compared to the EMF group. In this study, it can be concluded that the number and diameter of ovarian follicles decreased in rats exposed to electromagnetic field and 20 mg of carnosine may prevent damage caused by EMF.Öğe Investigating the anti-tumoral effect of yarrow (Achillea milllefolium) on the mice in which ehrlich solid tumor is created(Humana Press Inc, 2022) Uzun, Gokce Bagci; Nisari, Mehtap; Yay, Arzu Hanim; Karatoprak, Gokce Seker; Al, Ozge; Ucar, Sumeyye; Arslan, AylaIn this study, BALB/c mice with Ehrlich solid tumors were used to examine the effect of Achillea millefolium L. (AM) extract on the Ehrlich ascites tumor (EAT) model, which is one of the experimental cancer models. Also known as yarrow and plant, AM has antioxidant, anti-inflammatory, antibacterial and antitumor properties. In our study, 57 male BALB/c type mice, 8-10 weeks old, weighing 25-30 g, were used. Mice were divided into two groups. Ehrlich Solid Tumor group: Negative Control Group (ENC), Positive Control Group (EPC), and Treatment Group (TG) (TNCAM-200 mg/kg, TPCAM-400 mg/kg). EPC and TG were given to EAT cells. Each EAT contained 1 x 106 (will be 6 out of 10: so:000000) EAT cells, 0.1 ml of phosphate-buffered saline (PBS) was administered subcutaneously (s.c.) to the nape of mice. Then It was awaited for solid tumor formation. AM extract was administered intraperitoneally (i.p.) to TG for 17 days to mice. AM extract was found to have a curative effect on areas of inflammation, bleeding, and necrosis in treatment groups treated with AM extract alone. The treatment groups showed nearly normal histological results compared to the positive control group. According to the results, the TPCAM-400 mg/kg group had a more significant histological impact than the TNCAM-200 mg/kg group. In terms of tumor growth, tumor length, tumor volume, and tumor weight, AM extract did not show significant effects. However, in the light of histological findings, promising results of AM were observed in mice in which Ehrlich Solid Tumor was formed.Öğe Morphometry and Variation in Os Sacrum(2023) Uzun, Gökçe Bağcı; aydın, merve; Arpaçay, BURCU Kamaşak; Zencirci, Büşra; ULCAY, TUFAN; PEKMEZ, HIDIR; Nisari, MehtapAim: The merger of the fifth lumbar vertebrae with the first sacral vertebrae is called the sacralisation of the lumbar vertebrae. The purpose of this study, changes in the os sacrum with sacralisation were detected, and morphometric measurements were made.Materials and Methods: Measurements on 30 sacrum bones in the laboratory from the Department of Anatomy were performed using a digital caliper with a sensitivity of 0.01 millimeters (mm). Os sacrum measurements were taken. Results: In one of the examined sacrums, it was found that tuberositas ossis sacri had the form of a pit, and on the underside of it, there was a pronounced groove. The processus transverse of the last lumbar vertebra fused with the os sacrum was not noticeably fused. Partial sacralisation was detected in the linea transversa at the anterior junction of the os sacrum and the last lumbar vertebra. It was determined that 21 of the sacrums had four foramina sacralia, and 9 of them had five variational foramina sacralia. Conclusion: It was determined that structural changes might occur in the sacrum and that the number of foramina sacralia may be different. We believe that knowing the morphometric measurements of the sacrum will guide clinicians in the analysis of sacrum fractures and sacrum.
