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    Effects of quercetin on methotrexate-induced nephrotoxicity in rats
    (Sage Publications Ltd, 2017) Yuksel, Yasemin; Yuksel, Ramazan; Yagmurca, Murat; Haltas, Hacer; Erdamar, Husamettin; Toktas, Muhsin; Ozcan, Osman
    Objective: This experimental study was conducted to elucidate the possible protective/therapeutic effects of quercetin against methotrexate (Mtx)-induced kidney toxicity with biochemical and histopathological studies. Methods: Twenty-four adult male rats were randomly divided into four groups, as follows: control group (saline intraperitoneally (i.p.), 9 days), Mtx group (20 mg/kg i.p., single dose), Mtx + quercetin group (50 mg/kg quercetin was orally administered 2 days before and 6 days after Mtx administration) and only quercetin group (50 mg/kg oral, 9 days). Structural changes were evaluated by hematoxylin-eosin and periodic acid-Schiff stainings. Apoptotic changes were investigated by terminal deoxynucleotidyl transferase dUTP nick end labeling assay and caspase-3 antibody. Superoxide dismutase (SOD) and malondialdehyde (MDA) levels were measured in tissue and plasma samples. Results: Mtx compared with the control group, there was significant increase in nephrotoxic tissue damage findings, in addition to apoptotic index (APOI) and caspase-3 expression (p < 0.05). Mtx + quercetin group revealed significantly lower histopathological damage and APOI and caspase-3 expression decreased when compared to Mtx group. MDA levels were increased in Mtx group compared to others, and by the use of quercetin, this increase was significantly reduced. SOD levels were higher in Mtx group than others. This increase was evaluated as a relative increase arising from oxidative damage caused by Mtx. Conclusion: As a result, Mtx administration may involve oxidative stress by causing structural and functional damage in kidney tissue in rats. Quercetin reduced the Mtx-induced oxidative stress through its antioxidant properties and so quercetin may be promising to alleviate Mtx-induced renal toxicity.
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    The acute and long term effects of acupuncture on heart rate variability
    (Natl Inst Science Communication-Niscair, 2015) Ozcan, Osman; Gunduz, Busra; Artut, Elif; Simbil, Kevser; Mansuroglu, Ayse Nazli; Akcaozoglu, Elif Beyza; Aydin, Duygu
    In a recent study, the possible effect of acupuncture in modulating heart rate variability (HRV) in both healthy and non-healthy subjects were reported, while previous review reported that acupuncture did not have any convincing effect on HRV in healthy subjects. We aimed to reinvestigate the possible helpful effect of acupuncture on HRV parameters and to test the possible differences between acute and long term (20 minutes) acupuncture applications. Twenty nine female subjects were participated in this study. For the acupuncture therapy, HT 7 acupuncture point (shen men) was selected. Acupuncture needle was placed for 1 minute in acute acupuncture application and 20 minutes in long term acupuncture. The recording ECG (HRV) was applied before and after acute and long term acupuncture therapies. Almost all HRV parameters increased after the acute acupuncture and some HRV parameters after the long term acupuncture compared to before therapy in healthy persons. There were no differences between acute and long term applications. These results indicate that acupuncture might be cardio protective and might restore sympathovagal imbalances by stimulating the peripheral nervous system. Also, the long term acupuncture application is not essential for the cardio protective effect.
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    The effects of hypnotherapy during transrectal ultrasound-guided prostate needle biopsy for pain and anxiety
    (Springer, 2015) Hizli, Fatih; Ozcan, Osman; Selvi, Ismail; Eraslan, Pinar; Kosus, Aydin; Bas, Okan; Yikilmaz, Taha Numan
    Several studies evaluating the tolerance of transrectal ultrasound (TRUS)-guided needle biopsies showed that moderate-to-severe pain was associated with the procedure. Additionally, prebiopsy anxiety or rebiopsy as a result of a prior biopsy procedure is mentioned as factors predisposing to higher pain intensity. Thus, in this study, we investigated the effects of hypnotherapy during transrectal ultrasound-guided prostate needle biopsy for pain and anxiety. Sixty-four patients presenting for TRUS-guided prostate needle biopsy were randomly assigned to receive either 10-min presurgery hypnosis session (n = 32, mean age 63.5 +/- A 6.1, p = 0.289) or a presurgery control session (n = 32, mean age 61.8 +/- A 6.8, p = 0.289). The hypnosis session involved suggestions for increased relaxation and decreased anxiety. Presurgery pain and anxiety were measured using visual analog scales (VAS), Beck Anxiety Inventory (BAI), and Hamilton Anxiety Scale (HAS), respectively. In our statistics, p < 0.05 was considered statistically significant. Postintervention, and before surgery, patients in the hypnosis group had significantly lower mean values for presurgery VAS [mean 1 (0-8); p = 0.011], BAI (6.0 vs 2.0; p < 0.001), and HAS (11.0 vs 6.0; p < 0.001). The study results indicate that a brief presurgery hypnosis intervention can be an effective means of controlling presurgical anxiety, and therefore pain, in patients awaiting diagnostic prostate cancer surgery.