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    Acute Abdominal Pain with an Unusual Etiology: Splenic Infarction in a Diabetes Patient
    (Aves, 2016) Yalaza, Metin; Kafadar, Mehmet Tolga; Degirmencioglu, Gurkan; Turkan, Ahmet; Sen, Meral
    Splenic infarction is a rare clinical event caused by reduced blood flow to the spleen. Its presentation can mimic other causes of acute abdominal pain. The most frequent causes of splenic infarction include thromboembolic events, malignant hematologic neoplasms, and vasculitides. A few reports of single or multiple cases of diabetes-induced splenic infarction have been published in medical journals. Herein, we report a 67-year-old patient with diabetes-associated splenic infarction who presented to an emergency department with acute abdominal pain.
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    An Unusual Presentation of Lung Cancer Metastasis: Perianal Abscess
    (Derman Medical Publ, 2014) Kilic, Murat Ozgur; Sen, Meral; Turkan, Ahmet; Yildirim, Umran; Koktener, Asli
    Lung cancer is one of the most commonly diagnosed cancers in both men and women. Although the most frequent sites of distant metastasis of lung cancers are the pleura, liver, adrenal glands, skeletal system and brain, perianal region has been rarely reported as a metastasis site. A male patient was admitted to our emergency room with a long standing perianal abscess. During abscess drainage, a mass was noticed at the base of the abscess pouch, and thus a biopsy was taken. Pathologically, it was reported as a metastasis of squamous cell carcinoma, therefore some radiological investigations and endoscopic procedures were performed to determine the primary focus of cancer. A pulmonary mass was revealed in PET/CT, and was considered as primary tumor. Both primary and metastatic perianal tumors can be rarely presented as an abscess formation. In this situation, a biopsy should be performed from the lesion to avoid misdiagnosis.
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    Can mastalgia be another somatic symptom in fibromyalgia syndrome?
    (Hospital Clinicas, Univ Sao Paulo, 2015) Sen, Meral; Kilic, Murat Ozgur; Cemeroglu, Ozlem; Icen, Duygu
    OBJECTIVE: The purposes of this study were to determine the coexistence of mastalgia and fibromyalgia, to investigate the effects of this combination on pain patterns, and to discuss the status of breast pain in the diagnostic algorithm of fibromyalgia syndrome. METHODS: Sixty-one female patients reporting breast pain during the last three months and 53 female patients diagnosed with fibromyalgia syndrome were enrolled in this study. The Breast Pain Questionnaire was administered to all participants in the mastalgia group and to those in the fibromyalgia syndrome group who had experienced mastalgia during the past three months. The patients in the fibromyalgia syndrome group were evaluated using the 2010 preliminary American College of Rheumatology classification criteria. All of the patients in the mastalgia group were evaluated for the diagnosis of fibromyalgia syndrome by a single physiatrist. The coexistence and pain patterns of mastalgia and fibromyalgia were assessed statistically. RESULTS: Approximately half of the patients with fibromyalgia syndrome (47.2%) reported having mastalgia at the time of admission and 37.7% of the patients with mastalgia met the diagnostic criteria for fibromyalgia syndrome. The patients with mastalgia in the fibromyalgia syndrome group had significantly higher total breast pain scores compared with the women in the mastalgia group. In addition, the patients with fibromyalgia syndrome in the mastalgia group had significantly higher Widespread Pain Index and Symptom Severity Scale scores than the patients with fibromyalgia syndrome. CONCLUSIONS: We suggest that mastalgia can be an aspect of the central sensitivity syndrome and can be added to the somatic symptoms of fibromyalgia.
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    Giant gluteal pilomatrixoma: An uncommon tumor in a rare localization
    (Marmara Univ, Fac Medicine, 2015) Kilic, Murat Ozgur; Sen, Meral
    Pilomatrixoma is an uncommon, benign subcutaneous tumor arising from the hair follicle matrix. This tumor occurs more commonly in children than in adults, and most often originates on the head, neck or upper extremities. Gluteal region is an extremely rare site of pilomatrixoma. Multiple presentation is an unusual condition and often associated with some familial syndromes such as myotonic dystrophy, Gardner syndrome and Turner syndrome. Pilomatrixoma mostly presents as a painless, firm, slow-growing subcutaneous mass, and is usually encapsulated by connective tissue and sharply demarcated from the surrounding normal tissue. Both clinical and radiological findings are non-specific, and therefore histopathology is necessary to reach correct diagnosis. These lesions have very low risk of malignant transformation, and surgical excision with adequate margins is the treatment of choice. Herein, a rare case of gluteal pilomatrixoma with multiple presentation in the upper extremities in a young female patient was presented.
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    Myofibroblastoma: A rare benign breast tumor in a male case
    (Yerkure Tanitim & Yayincilik Hizmetleri A S, 2017) Kilic, Murat Ozgur; Sen, Meral; Dener, Cenap; Yenidunya, Sibel
    Myofibroblastoma is a rare benign mesenchymal tumor of the breast. A small number of cases have been reported in the literature. It is often seen in postmenopausal women and older men. In general, MFP occurs slow-growing within months, well-circumscribed, mobile, single-sided and a hard mass. Due to the variety of morphological variants, it is difficult to distinguish from other breast masses by imaging techniques, tru-cut biopsy plays a key role in diagnosis. Local excision of myofibroblastoma as a benign tumor of the breast is curative. Malign transformation and recurrence after surgery have not been reported. Knowing the right approach to this rare breast mass by general surgeons, reduce unnecessary and mistreatments. We presented a new case of myofibroblastoma which is found in a 42 years old male patient's breast, due to its rarity.
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    The effect of survivin gene promoter polymorphism on breast cancer
    (Tubitak Scientific & Technological Research Council Turkey, 2014) Altiparmak, Mehmet Deniz; Bilgic, Celal Ismail; Dener, Nuzhet Cenap; Gunduz, Esra; Yenidunya, Sibel; Acar, Muradiye; Sen, Meral
    Breast cancer is the most common malignant tumor in women and accounts for about 25% of all cancer diagnoses. Survivin is a member of the apoptosis inhibitor protein family of antiapoptotic proteins. In our study, we investigated one of those, the survivin gene promoter 31G/C polymorphism. Included in this study were 111 breast cancer patients who were operated on in our hospital and 101 healthy female subjects. Blood samples from the healthy subjects and paraffin-embedded tissue samples from the patients were used for DNA extraction and subsequent genetic analysis. PCR-RFLP was used for genotype analysis. We established the clinicopathologic characteristics of patients. No significant difference was found between survivin 31G/C promoter polymorphism of tumor characteristics and breast cancer. Between the control and breast cancer groups, survivin promoter polymorphism 31G/C differences were not significantly different (P = 0.058). The risk of developing cancer, having the relevant GC or CC genotype, is 1.413 times higher than those having genotype GG (95% confidence interval: 1.040 to 1.918). Carrying the C allele was statistically significant in terms of susceptibility to breast cancer. In conclusion, the use of survivin gene polymorphism as a risk factor in breast cancer is recommended based on the results of this study.