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    Causes of high erythrocyte sedimentation rates in elderly patients
    (2013) Uğuz, Nihal; Çelik, Hüseyin Tuğrul; Torun-Güngör, Oya; Bal, Ceylan Demir; Bakır, Fatih; Kazanci, Fatma; Yiğitoğlu, Ramazan
    Objective: The erythrocyte sedimentation rate (ESR) determination is a simple and inexpensive laboratory test that is frequently ordered in clinical medicine. The test measures the distance that erythrocytes have fallen after one hour in a vertical column of anticoagulated blood under the influence of gravity. In this study it was aimed to determine the frequency of diseases which ESRs were over 100 mm/h in patients aged 65 and over. Method: In this study patients aged 65 and over who were treated in Turgut Özal University Hospital were retrospectively examined. Patients whose ESRs were over 100 mm/h were analyzed recording their ages, genders, ESRs and diagnoses. Diagnoses were divided into five groups: (i) infection; (ii) malignancy; (iii) inflammatory/connective tissue diseases; (iv) renal diseases; (v) miscellaneous diseases. Results: Two hundred five patients aged 65 and over whose ESRs were over 100 mm/h were analyzed. 115 of patients were women (56%) and 90 of them were men (44%). Age means of patients were 74.9 ± 6.45 and ESR means were 114.9 ± 14.8. When distribution according to disease groups was assessed, infection took the first rank (37.5%), malignancy took the second rank (21.9%), miscellaneous diseases took the third rank (21.4%), renal diseases took the forth rank (15.1%). The frequency of inflammatory/connective tissue diseases was 3.9%. Conclusion: In elderly, the most common cause of extreme elevation of ESR is infection. Different from other age groups, malignancy was found as the second common reason causing elevation of ESR. When etiology was researched in patients with extreme elevation of ESR, the age factor must be taken into consideration. © 2013 Elsevier B.V., All rights reserved.
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    Increased serum interleukin-33 levels in patients with Graves' disease
    (2013) Çelik, Hüseyin Tuğrul; Abuşoğlu, Sedat; Burnik, S. F.; Sezer, Sevilay; Serdar, Muhittin A.; Ercan, Müjgan; Uğuz, Nihal
    objective. Interleukin-33 (IL-33), a 30 kDa cytokine, is a member of IL-1 family. It is considered to be an autoimmune biomarker associated with T helper 2 (T 2) response. ?-interferon is also produced by T helper 1 (T 1) cells to induce cellular responses. ?-interferon is a 143-amino acid residue glycoprotein with several biological functions including potent anti-viral activity, stimulation of macrophage activity, modulation of Major Histocompatibilty Complex class I/class II expression, and regulation of a diversity of specific immune responses. Te aim of this study was to investigate the serum levels of IL-33 and ?-interferon in different thyroid disorders. Methods. Twenty patients with Graves' disease, 21 patients with Hashimoto hypothyroidism, 21 euthyroid Hashimoto patients, and 27 control subjects were recruited to this study. Blood samples were drawn and IL-33 and ?-interferon tests were analyzed from 89 participants. Serum IL-33 and ?-interferon analyses were performed by enzyme-linked immunosorbent assay. results. Tere was no statistically significant difference between groups for serum ?-interferon levels. Serum IL-33 concentrations were significantly higher in Graves' disease group compared to the other groups (p<0.000) There was a positive correlation between serum IL-33 and free triiodothyronine (fT3) and thyroxine (fT4). Also, negative correlation between serum IL-33 and thyroid-stimulating hormone (TSH) was statistically significant (p<0.000). Conclusions. Te correlation of serum IL-33 with thyroid hormone levels may be a useful indicator for Graves' disease. These findings may help to make evident the pathophysiologic processes of the autoimmune thyroid diseases and improve therapeutic methods. © 2013 Elsevier B.V., All rights reserved.; MEDLINE® is the source for the MeSH terms of this document.