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    Exploring the anti-inflammatory activity of boron compounds through the miR-21/PTEN/AKT pathway in cecal ligation and puncture-induced sepsis
    (Spandidos Publ Ltd, 2025) Sevim, Cigdem; Ozkaraca, Mustafa; Kara, Mehtap; Taghizadehghalehjoughi, Ali; Genc, Sidika; Yeni, Yesim; Mendil, Ali Sefa
    The present study investigated the impact of boric acid (BA) and borax (BX) on markers of inflammation and modifications in miR-21/PTEN/AKT pathway genes in the liver and kidney tissues of Sprague Dawley male rats with sepsis induced by cecal ligation and puncture (CLP). A total of 60 male Sprague Dawley rats were randomly divided into 6 groups, each containing 10 animals as follows: Control, CLP (where the model was created), 20 mg/kg BX (CLP + BX1), 40 mg/kg BX (CLP + BX2), 20 mg/kg BA (CLP + BA1) and 40 mg/kg BA (CLP + BA2). Liver and kidney tissues were analyzed for histopathological changes, immunopositivity for tumor necrosis factor-alpha, interleukin (IL)-6 and IL-10, and gene expression of microRNA-21 (miR-21), phosphatase and tensin homolog (PTEN) and AKT. Gene expression analysis in the liver tissues revealed a significant decrease in miR-21, and a marked but not significant decrease in PTEN levels in the CLP group, while AKT expression was significantly increased in the CLP group, and was significantly decreased in CLP + BA1 group compared with in the CLP group. In the kidney tissues, miR-21 levels were significantly decreased in the CLP group, but the CLP + BA2 group showed a significant increase compared with in the CLP group. These results suggest the potential therapeutic benefits of low-dose BA and BX in ameliorating sepsis-induced tissue damage, emphasizing the need for further exploration of their mechanisms of action.
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    In Vitro Effect of Boron Compounds in Combination with Photobiomodulation Therapy by 905 nm on the Viability of Human Gingival Fibroblasts
    (Kafkas Univ, Veteriner Fakultesi Dergisi, 2025) Turgut, Ferda; Yanmaz, Latif Emrah; Yildirim, Serkan; Taghizadehghalehjoughi, Ali; Yeni, Yesim; Okur, Sitkican; Orhun, Omer Tarik
    This study aimed to evaluate the effect of Low-level laser therapy (LLLT) and Boric acid (BA) or Borax decahydrate (BD) on the cell survival of gingival fibroblasts. Fibroblast planted plates were divided into 10 groups: Control group, BD 100 mu g/mL (BD 100), BD 200 mu g/mL (BD200), BA 100 mu g/mL (BA100), BA 200 mu g/mL (BA200), LLLT, LLLT+BD100 mu g/mL (LLLT+BD100), LLLT+BD200 mu g/mL (LLLT+BD200), LLLT+BA100 mu g/mL (LLLT+BA100) and LLLT+BA 200 mu g/mL (LLLT+BA200) groups. LLLT was performed at a dose of 4 J/cm2 for 160 sec. Following LLLT, MTT analysis was performed after the cells were kept in the incubator for 24 h. The LLLT+BA 200 group exhibited the highest cell density. In MTT analysis, significantly higher cell numbers were observed in the BA200, LLLT+BA100, and LLLT+BA200 groups compared to the control group (P<0.05). Then, the 3-(4,5-dimethyl thiazolyl-2)-2, 5-diphenyltetrazolium bromide assay and 8-hydroxy-2'-deoxyguanosine and Bcl-2 Associated X-Protein were analyzed. The 8-hydroxy-2'-deoxyguanosine and Bcl-2 Associated X-Protein levels were decreased in the LLLT+BA200 group compared to the control group (P<0.05). This study suggests that BA200, LLLT+BA100, and LLLT+BA200 increase the survival of fibroblast cells.