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Öğe ADAM9, ADAM10 and ADAM17 differentially regulated in male infertility(Wiley-Blackwell, 2016) Guven, K. N.; Bayram, N. A.; Pekel, A.; Yildirim, M. E.; Duvan, C. Iltemir; Cimentepe, E.; Onaran, Y.[Abstract Not Available]Öğe Effects of long-term heat stress and dietary restriction on the expression of genes of steroidogenic pathway and small heat-shock proteins in rat testicular tissue(Wiley, 2017) Bozkaya, F.; Atli, M. O.; Guzeloglu, A.; Kayis, S. A.; Yildirim, M. E.; Kurar, E.; Yilmaz, R.The aim was to investigate the effects of long-term heat stress and dietary restriction on the expression of certain genes involving in steroidogenic pathway and small heat-shock proteins (sHSPs) in rat testis. Sprague Dawley rats (n = 24) were equally divided into four groups. Group I and II were kept at an ambient temperature of 22 degrees C, while Groups III and IV were reared at 38 degrees C for 9 weeks. Feed was freely available for Group I and Group III, while Group II and Group IV were fed 60% of the diet consumed by their ad libitum counterparts. At the end of 9 weeks, testicles were collected under euthanasia. Total RNA was isolated from testis tissue samples. Expression profiles of the genes encoding androgen-binding protein, follicle-stimulating hormone receptor, androgen receptor, luteinising hormone receptor, steroidogenic acute regulatory protein (StAR), cyclooxygenase-2 and sHSP genes were assessed at mRNA levels using qPCR. Long-term heat stress decreased the expression of StAR and HspB10 genes while dietary restriction upregulated StAR gene expression. The results suggested that long-term heat stress negatively affected the expression of StAR and HspB10 genes and the dietary restriction was able to reverse negative effect of heat stress on the expression of StAR gene in rat testis.Öğe Protective Effect of Intravesical Platelet-Rich Plasma on Cyclophosphamide-Induced Hemorrhagic Cystitis(Canadian Soc Clinical Investigation, 2016) Ozyuvali, E.; Yildirim, M. E.; Yaman, T.; Kosem, B.; Cimentepe, E.Purpose: Hemorrhagic cystitis (HC) is the most common urotoxic side effect of cyclophosphamide (CYP). Platelet rich plasma (PRP) plays an important role in wound healing and inflammatory responses. The aim of this study was to investigate the efficacy of intravesical PRP at treatment of interstitial cystitis (IC). Methods: Female rats (n=24) were used. IC was induced by intraperitoneal injection of cyclophosphamide (CYP) and rats were randomly allocated to one of four groups (n = 6 per group): A control group; a sham group with saline (75 mg/kg; i.p.) instead of CYP on day 1, IC group, which was injected with CYP (150 mg/kg; i.p.) on day 1; and, an intravesical PRP-treated group which was injected with CYP (150 mg/kg; i.p.) on day 1. On day 2, the rats in each group were sacrificed under anesthesia. Results: Histological evaluation showed CYP administration induced severe IC with marked edema, hemorrhage and inflammation in CYP and CYP+PRP groups, but that PRP did not suppress these histopathological changes. Conclusion: PRP did not suppress the histopathological changes in rats that had IC due to cyclophosphamide injection.Öğe Relationship of galectin-3 to left ventricular geometry and hypertrophy in chronic hemodialysis patients(Urban & Vogel, 2015) Yilmaz, H.; Gurel, O. M.; Celik, H. T.; Bozkurt, A.; Yildirim, M. E.; Bilgic, I.; Bilgic, M. A.Aim and background. Galectin-3 (Gal-3) is used to determine the prognosis of heart failure. Some studies revealed that Gal-3 promoted cardiac hypertrophy but there is no study in which the relationship between -Gal-3 and left ventricular hypertrophy (LVH) geometry in patients without diastolic and systolic function impairment has been explored. The aim of the study was to analyze associations between plasma Gal-3 levels, LVH, and LV geometry in maintenance hemodialysis (HD) patients without systolic and diastolic dysfunction. Patients and methods. The study group included 105 patients (53 women and 52 men)-with an average age of 58.2+/-12.6 years, treated with HD for an average of 45+/-32 months-and 60 healthy controls. The Gal-3 and other biochemical parameters were measured and color Doppler echocardiography was performed. For this study LVH was considered present when the LV mass index (LVMI) exceeded 95 g/m(2) in women and 115 g/m(2) in men. Left ventricular geometry was classified into the four groups on the basis of left ventricular mass and relative wall thickness (RWT). Results. Concentric hypertrophy (CH, 40.9%, n= 43) was the commonest geometric pattern in our study. The Gal-3 levels in CH patients were not different from the patients with eccentric hypertrophy (EH). Plasma levels of Gal-3 correlated with LVMI (r= 0.617, p< 0.001), parathyroid hormone (PTH, r= 0.408, p< 0.001), uric acid (r= 0.281, p = 0.004), C-reactive protein (CRP, r= 0.412, p< 0.001), and RWT (r= 0.281, p = 0.004) but were inversely correlated with albumin (r=-0.466, P< 0.001) in the whole group. Plasma levels of Gal-3 were associated with LVMI (r= 0.812, P< 0.001), RWT (r= 0.318, p = 0.001), and CRP(r= 0.381, p< 0.001) in maintenance hemodialysis patients. Conclusion. The Gal-3 level is related to left ventricular hypertrophy and it is independent of left ventricle geometry. The relationship between LVH and Gal-3 might be direct or it may also be inflammation-related.Öğe SURGICAL TREATMENT IN WOMEN WITH ANORGASMIA: OUR INITIAL EXPERIENCE RESULTS(Wiley-Blackwell, 2014) Karatas, O. F.; Badem, H.; Incebay, I. B.; Cavis, M.; Cimentepe, E.; Yildirim, M. E.[Abstract Not Available]Öğe The association between plasma visfatin levels and ED(Nature Publishing Group, 2015) Karatas, O. F.; Yildirim, M. E.; Celik, H. T.; Badem, H.; Cavis, M.; Cimentepe, E.Visfatin was initially proposed as a clinical marker of atherosclerosis, endothelial dysfunction and vascular damage, with a potential prognostic value. It has been shown that endothelial dysfunction has an important role in ED. We aimed to determine the levels of visfatin in ED patients and characterize the relationship between visfatin levels and ED. This case-control study was conducted between October 2010 and August 2012, and 41 severe ED patients (group 1) and 36 healthy controls (group 2) were involved. Fasting visfatin level was measured with enzyme-linked immunosorbent assay method. The groups were compared in terms of some clinical (height, weight and body mass index) and biochemical parameters (glucose, triglycerides, cholesterol, low-density lipoprotein and high-density lipoprotein). No statistically significant difference in the visfatin levels was found between the patients and the controls (17, 5 +/- 14.4, 14, 9 +/- 7 and 9, respectively, P=0.399). No difference in the other clinical and biochemical parameters was observed between the two groups. No significant difference in the serum visfatin levels of ED patients compared with healthy patients was noticed. Further studies are needed to confirm the effect of visfatin on cardiometabolic diseases and ED, indeed.Öğe THE PREDICTIVE EFFECT OF NEUTROPHIL/LYMPHOCYTE RATIO ON THE SEVERITY OF ERECTILE DYSFUNCTION(Wiley-Blackwell, 2014) Yildirim, M. E.; Badem, H.; Cavis, M.; Karatas, O. F.; Cimentepe, E.[Abstract Not Available]
