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Öğe Resistin predicts ischemia in myocardial perfusion scintigraphy(Tubitak Scientific & Technological Research Council Turkey, 2014) Yildirim, Mustafa; Erkan, Melih Engin; Asik, Muhammet; Ucgun, Taner; Yilmaz, Ayse; Ilce, Huri Tilla; Aslantas, YusufAim: Resistin plays a role in the pathogenesis of coronary artery disease and is related to mortality and morbidity through a number of mechanisms. We hypothesize that plasma resistin levels are increased in the presence of ischemia, as measured by GATED single-photon emission computed tomography myocardial perfusion scintigraphy (SPECT MPS), in comparison with nonischemic subjects. Materials and methods: Fasting intravenous blood samples of patients were drawn before a stress test. An ELISA kit was used for the assays. All patients underwent a technetium 99m-sestamibi GATED SPECT MPS study with a 1-day stress-rest protocol. Images were analyzed visually and patients were assessed as ischemic or nonischemic. Resistin levels were presented as medians (25th-75th percentiles) and were compared using the Mann-Whitney U test. Results: Plasma resistin levels were higher in the ischemic group (n = 47) than in the nonischemic group (n = 67) [9.04 mu mol/L (6.27-11.8 mu mol/L) vs. 3.56 mu mol/L (0.39-7.93 mu mol/L), respectively; P < 0.001). We showed that plasma resistin levels (OR = 1.26, 95% CI: 1.13-1.41; P < 0.001) and METs (OR = 0.82, 95% CI: 0.70-0.92; P = 0.021) were independent predictors of ischemia. No linear correlation was found between plasma resistin levels and GATED SPECT or stress test parameters. Conclusion: Increased baseline resistin levels are independently related to presence of ischemia but are not related to the extent or severity of ischemia, or other functional parameters such as poststress ejection fraction, end systolic, and end diastolic volumes.Öğe Tc-99m MDP bone scintigraphy in the evaluation of the joint damage in asymptomatic alpine ski racers(Tubitak Scientific & Technological Research Council Turkey, 2014) Varoglu, Erhan; Yildirim, Mustafa; Gursoy, Recep; Seven, Bedri; Uslu, Hatice; Cogalgil, Sirzat; Kiyici, FatihAim: To evaluate the role of 99m-technetium methylene diphosphonate (Tc-99m MDP) bone scintigraphy on the detection of joint damage in asymptomatic alpine ski racers. Materials and methods: This study included 20 male asymptomatic alpine ski racers (age range: 18-21 years). None of the skiers had a history of ski crashes. Bone scan findings of the racers were examined with Tc-99m MDP bone scintigraphy during the active racing season and the inactive training season. Planar anterior and posterior images of hip, knee, and ankle joints were obtained 4 h after intravenous injection of 20 mCi Tc-99m MDP. All images were interpreted visually by 2 experienced nuclear medicine physicians. Free regions of interest were drawn on hip, knee, and ankle joints, as well as background regions. Joint-to-background ratios were calculated for each joint, and the uptake ratios of both right and left joints during active ski season were compared to those during the inactive training period. Results: Uptake ratios of the right and left hip, knee, and ankle joints were significantly higher during the active racing period than those calculated during the inactive period (P < 0.005). Conclusion: Bone scintigraphy may have an important role in detecting joint injuries of hip, knee, and ankle joints in asymptomatic alpine ski racers and can be used successfully when MRI is unavailable.Öğe The relationship between insulin resistance and the parameters obtained from gated spect myocardial perfusion scintigraphy(Duzce University Medical School, 2014) Aşık, Muhammet; Erkan, Melih Engin; Yilmaz, Ayşe Esra; Uçgun, Taner; Korkmaz, Ayşe Nurdan; Yılmaztekin, Mehmet Zeki; Yildirim, MustafaPurpose: To investigate the correlation between myocardial perfusion scintigraphic findings and insulin resistance. Methods: Our study group consisted of 153 non-diabetic patients (80 women and 73 men, mean age 54 ± 12), referred to our department for the myocardial perfusion scintigraphy with suspected coronary artery disease between October/2011-April/2012., Fasting insulin and blood sugar levels were measured. Insulin resistance was calculated using HOMA-IR method. Left ventricular quantitative parameters were automatically calculated using quantitative GATED SPECT (QGS) software. Results: According to the scintigraphic results, 90 (58.8%) of the patients were normal and 48 (31.3%) of the patients had ischemia. Mean insulin values of patients were found to be 9.06±13.95 in normal group and 7.50±5.71 in the ischemic group (p=0.943). Additionally, HOMA-IR was 2.19±3.59 in normal group and 1.71±1.34 in the ischemic group (p=0.368). There was no significant difference between scintigraphic findings and insulin resistance or HOMA-IR results. Conclusion: We found no significant correlation between insulin resistance and cardiovascular risk parameters obtained from GATED SPECT MPS. © 2021 Elsevier B.V., All rights reserved.Öğe The Relationship between Mean Platelet Volume and the Parameters Obtained From Gated Spect Myocardial Perfusion Scintigraphy(Duzce Univ, 2014) Izgi, Erdinc; Erkan, Melih Engin; Korkmaz, Ayse Nurdan; Asik, Muhammet; Yilmaz, Ayse; Yilmaztekin, Mehmet Zeki; Yildirim, MustafaObjective: It is previously emphasized that mean platelet volume (MPV) is a useful parameter in predicting coronary artery disease and related morbidity and mortality. The purpose of this study is to investigate the relationship between myocardial perfusion scintigraphic findings and mean platelet volume (MPV), which is a simple and reliable parameter of platelet function in patients with suspected coronary heart disease. Methods: In this retrospective study, 344 patients who underwent myocardial perfusion scintigraphy in our clinic between 2009 and 2012 were included. The study group consisted of 139 men and 205 women (mean age 56.67 +/- 11,16). Based on the scintigraphic findings, patients were divided into three groups as normal, suspicious for ischemia and significant ischemia. The results of MPV and the parameters obtained from GATED myocardial perfusion SPECT scintigraphy such as stress ejection fraction, end-systolic volumes and end-diastolic volumes were correlated. Results: 96 (27,9%) of the patients were normal, 98 (28,5%) were suspicious for ischemia and 150 (43,6%) showed significant ischemia. MPV values of patients were found to be 8,43 +/- 1,19 in normal group, 8,10 +/- 1,34 in suspicious ischemic group, 8,06 +/- 1,23 in significant ischemic group. There was no significant difference between scintigraphic findings and MPV results. (p=0,060) Conclusion: In our study, it was found that there was not relationship between MPV, which is considered as a risk factor for cardiovascular disease, parameters of GATED myocardial perfusion SPECT scintigraphy and myocardial ischemia.
