Yazar "Yologlu, Saim" seçeneğine göre listele

Listeleniyor 1 - 2 / 2
  • Küçük Resim Yok
    Öğe
    Comparative analysis of models in confirmatory factor analysis: Exploring clinical applications and interpretation
    (2023) İnceoğlu, Feyza; Yologlu, Saim; kanik, arzu
    To demonstrate the explainability of the scales with fewer dimensions instead of the number of existing dimensions by ensuring that the scale structures created by explanatory factor analysis (EFA) are verified with confirmatory factor analysis (CFA). Data from the Nutritional Behavior Scale in Children, answered by the parents of 204 children with autism spectrum disorder (ASD) were used. EFA was performed with the data obtained from the scale. In the next step, the explained variance percentages and dimensions were determined and the model goodness of fit indexes were calculated with CFA. The dimensions with the lowest explained variance percentages were removed from the model, respectively, and three different scale models were tested. The variance explanation percentage of the first eight-dimensional model created with EFA was calculated as 72.68%. The food fussiness sub-dimension was removed and CFA was applied to the model again and new indices were calculated. Finally, the emotional under-eating sub-dimension was excluded from the model, resulting in a six-dimensional Child Eating Behavior Scale (CEBS). Goodness-of-fit indices of the CFA model established with six dimensions were ?2 / df; 1.545, AIC; 715,433 and RMSEA; 0.052 was found. It has been shown that the eight, seven, and six-dimensional scale models constructed according to the percentages of variance explained for CEBS are sufficient to explain the sample and that the six-dimensional scale model can be used for CEBS. Our study is the first to use competing models in confirmatory factor analysis in reducing scale dimensions.
  • Küçük Resim Yok
    Öğe
    Effects of various conditions related to circadian rhythm disturbances on plasma and erythrocyte lipids in rats: a peroxisomal perspective
    (2024) Otlu, Hüsniye Gül; UGUR, Yılmaz; Yıldız, Azibe; Erdoğan, Selim; Yologlu, Saim; Vardi, Nigar; Güldür, Tayfun
    Purpose: Lipidomics studies of sleep restriction, which is known to be associated with circadian perturbations, revealed alterations in some plasma phospholipid levels including plasmalogens which are partly synthesized in liver peroxisomes. To this end it was aimed to investigate effects of various conditions known to cause circadian rhythm disturbances on various peroxisomal parameters and to compare those effects with that of fenofibrate, a peroxisome proliferator-activated receptor alpha agonist. Materials and methods: Plasmalogens and some fatty acids in erythrocyte lysates were analyzed by GC. Peroxisomal metabolites including very long chain fatty acids as well as phytanic and pristanic acids in plasma were measured by GC-MS. Immunohistological analyses by catalase antibodies were conducted on liver sections. Results: All the conditions tested exhibited increased catalase immunoreactivity in liver sections compared to that of controls. Both calorie restriction, time-restricted feeding, as well as fenofibrate treatment exhibited lower C18:0 plasmalogen contents of erythrocyte lysates. As plasmalogens are known to be synthesized by peroxisomes, the present results suggest that the peroxisomal lipid content in membranes might be affected by conditions co-occuring with circadian perturbations. Conclusion: Shared effects of conditions associated with circadian rhythm disturbances and peroxisomal induction by fenofibrate on erythrocyte membrane lipids might indicate a link between them.