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Öğe Assessing Uterine Rupture: A Bibliometric Analysis of a Critical Emergency for Women’s Health(2024) yildirim, engin; özensoy, habibe selminObjective: This study aimed to provide a comprehensive bibliometric analysis of academic literature related to uterine rupture, highlighting trends, publication productivity, and key contributors in this critical area of women’s health. Materials and Methods: A comprehensive analysis of the Web of Science (WoS) database was conducted, encompassing articles published from 1980 to 2023. Keywords “uterine rupture” and “uterus rupture” were utilized. Data visualization was facilitated using Datawrapper, while VosViewer 2019 was used to analyze coauthorship and citation networks. Results: A total of 5.828 publications were identified, of which 5.745 were analyzed after excluding studies from 2024. The United States, England, and France emerged as the top contributing countries. The American Journal of Obstetrics and Gynecology was the leading journal. The publication rate has steadily increased, peaking in 2020. The most cited article, “risk of uterine rupture during labor among women with a prior cesarean delivery” reflects ongoing concerns in obstetric care. Collaborations between researchers and institutions are evident, with significant networks formed around key authors. Conclusion: Uterine rupture remains a pressing clinical issue, increasingly prevalent due to rising cesarean rates. Emergency physicians and obstetricians should understand the risk factors and diagnostics. Continued growth in research publications is anticipated, with a focus on multidisciplinary approaches to enhance understanding and management strategies for uterine rupture.Öğe Association between serum copeptin levels and non-obese normoglycemic polycystic ovary syndrome: A case control study(2024) yildirim, engin; GORKEM, UmitObjective: Copeptin is a glycopeptide that increases under stress and is present in polycystic ovary syndrome (PCOS) patients with metabolic system disorders. We examined the relationship between copeptin and reproductive function in patients with normoglycemic PCOS with anovulatory cycles and normal weight. Materials and Methods: Women with unexplained infertility (n=52) and women with PCOS (n=57) were included in the study. PCOS was determined using the Rotterdam criteria. Biochemical tests including estradiol, follicle-stimulating hormone, luteinizing hormone, anti-Müllerian hormone (AMH), insulin, and copeptin were performed. Serum copeptin concentrations were measured using enzyme immunoassay. Results: There were no significant differences in demographic data, insulin levels, and insulin resistance between the PCOS and healthy volunteers. Copeptin levels were lower in the PCOS group (p<0.001). A significant negative correlation was observed between AMH and copeptin in the control group (r=-0.402, p= 0.013). In the PCOS group, a negative correlation was observed between antral follicle count and copeptin, as well as between AMH and copeptin (r=-0.544, p<0.01). Receiver operating characteristic (ROC) curve analysis was performed to determine the predictive value of copeptin levels. The estimated areas under the ROC curves for serum concentration were found to be statistically significant (p<0.001) with a cut-off value of 2.78 (95% confidence interval 0.701-0.896), sensitivity of 0.87, and specificity of 0.70. Conclusion: This study showed that copeptin levels are lower in patients with PCOS in the absence of insulin resistance and obesity than in healthy volunteers, and there is a negative correlation between copeptin and reproductive markers.Öğe Could ELABELA be a Protective Biomarker in Patients with Abnormal Uterine Bleeding?(2024) KIRAN, TUGBA RAIKA; Doğan, Ümran Karabulut; Otlu, Önder; yildirim, engin; Erdem, Mehmet; İnceoğlu, FeyzaAim: Abnormal uterine bleeding (AUB) is a health problem characterized by various symptoms such as heavy and prolonged menstrual bleeding, affecting approximately 30% of female patients both physiologically and psychologically. The objective of this study was to assess serum Elabela (ELA) concentrations in women aged 18 and above diagnosed with functional AUB, and to compare these concentrations with those of healthy women. Material and Method: This prospective case-control study was performed from August 18, 2022 to December 30, 2022. This was a cross-sectional study including 50 women who applied to the gynecology service of Malatya Turgut Özal Training and Research Hospital with complaints of AUB and 50 women without AUB who underwent gynecological examination. The presence of AUB in patients was determined based on clinical examination conducted by a gynecologist and medical records. Demographic and clinical characteristics were recorded. Serum ELA levels were determined by commercial ELISA kit. Results: Serum ELA levels was significantly lower in patients with AUB (581.54±272.25 pg/mL) compared to the healthy group (744.55±300.31 pg/mL, p=0.005). In this study, ELA in patients with AUB showed 98% sensitivity and 80% specificity with a cut off value of 411.41 pg/mL (area under the curve [AUC], 68.1%; p=0.002). Conclusion: Serum ELA levels in patients with AUB were significantly lower than in healthy women. These results show that ELA is a good predictor of the pathophysiological process of AUB.Öğe Global Trends in Prenatal Mosaicism Research: Insights from a Bibliometric Analysis (1980–2023)(2025) yildirim, engin; Yuksel, Sengul; Cigremis, Yilmaz; Yavemlier, Esra; Erdoğan, ErcanBackground: The coexistence of at least two cell lines with different genetic structures (chromosomal or single gene mutation) originating from the same zygote in an organism is defined as mosaicism. This study aimed to present a medical perspective by examining scientific articles published on diagnosis of prenatal mosaicism from a perinatal and genetic perspective with statistical methods. Methods: The source of our study is the Web of Science (WoS) database. The articles indexed between 1980-2023 were included in our research in the database, and the studies of 2024 were not included since the effect factors are not clear yet. While searching the database, the words “Prenatal Mosaicism” were used as keywords Results: We reached a total of 2124 publications by analyzing the WoS database using the term \"prenatal mosaicism\". When the citations of the documents written about prenatal mosaicism are evaluated, we found that the highest citation was made in 2022. Co-citation analysis has shown that there are 9932 authors investigating the issue of prenatal mosaicism. Collaboration and citation collaboration was observed between Mackay Memorial Hospital, National Taiwan University and National Yang Ming University. Prenatal screening and Aneuploidy were found the strongest relationship with prenatal mosaicism. Conclusions: It is observed that the publications related prenatal mosaicism are associated with prenatal diagnosis and screening and this diagnosis has the highest publication, citation and impact power.Öğe Vascular effects of gestational diabetes can be recognized by carotid intima-media thickness: a prospective case-control study(2023) kahraman, ercan; SENTURK, Metin; ALADAĞ, HÜLYA; yildirim, enginGestational diabetes mellitus (GDM) is a systemic disease that has poor maternal and fetal health outcomes. Patients who are diagnosed with GDM are more likely to encounter cardiovascular system diseases during pregnancy and after birth. Carotid intima-media thickness (CIMT) is used as an early indicator of diseases such as coronary artery disease. This study aims to define the effects of hyperglycemia at an early term using CIMT, maternal and fetal doppler flows in patients diagnosed with GDM. The study included 132 pregnant women who had reached the 24th gestational week. (GDM group n=65, Control group n=67) Comparisons were performed between women with similar demographic characteristics who received a 100-gr oral glucose test (OGT) and GDM diagnosis and who did not. The participants’ routine hemograms and biochemical tests were done during OGT. Fetal biometrics, amniotic fluid index, uterine artery doppler flow, and bilateral CIMT measurements were performed during the obstetric examinations. Gravida, para, and live birth rates of the GDM group participants were higher than those of the control group (p=0.003, 0.002, 0.002 respectively). The amniotic fluid index was found to be higher in the GDM group (p<0.001). Fasting glucose values and platelet counts were higher in the GDM group (p=0.031 and p<0.001). Other laboratory data demonstrated no statistically meaningful differences between the groups (p>0.05). When the doppler measurements were compared, umbilical artery pulsatility index values were discovered to be similar between the groups (p=0.509). While the right uterine artery (UtA) pulsatility index was higher in the GDM group (p<0.001), no statistically significant differences were found between the groups in terms of the left UtA pulsatility index (p=0.485). Right and left CIMTs were higher in the GDM group (p=0.001, p<0.001, p<0.001 respectively). While in the GDM group there was a positive correlation between the thrombocyte level and uterine artery resistance (r=0.336, p=0.006; r=0.397, p=0.044 respectively), no similar correlations were found in the control group. This study found that GDM patients had inflammation, increased resistance in uterine artery flow, and increased CIMT. It has been shown, there is a correlation between CIMT and glucose levels and between thrombocytosis and UtA resistance in GDM patients. Uterine artery doppler data and CIMT measurements could be used as an indicator of systemic inflammation and cardiovascular disease in patients with GDM.
