Journal of Medical Topics and Updates
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Öğe Sistemik immun-inflamatuar indeks alzheimer hastalığının tanısı ve takibi için yeni bir gösterge olabilir mi?(MTÜ, 2022) Bolayır, Aslı; Bay Karabulut, AysunBackground: Alzheimer's disease (AD) is a chronic neurodegenerative disease whose prevalence continues to increase in the elderly population. It has been shown that the neutrophil/lymphocyte ratio (NLR), is increased in AD compared to the normal population. However, there is no study in the literature regarding the role of systemic immune-inflammatory index (SII), which is calculated according to the formula of peripheral platelet count X neutrophil count/lymphocyte count, in AD. Therefore, our aim in this study was to reveal the role of SII in the diagnosis and follow-up of AD and to determine the relationship of this value with severity, duration of disease and drug use by comparing it with NLR. Materials and Methods: Our retrospective study consisted of 94 gender and age matched healthy volunteers and 102 patients who applied to our clinic were diagnosed with AD. Results: There was no difference between the patient and control groups in terms of age, gender, platelet and neutrophil counts, and SII values. While lymphocyte count was lower in-patient group; NLR and CRP detected higher (p=0.001, p=0.001, p=0.001, respectively). While SII increased as both disease duration and severity elevated; no statistically significant correlation was found between NLR and the severity and duration of the disease and drug use. Conclusions: Based on the data of our study, we can suggest that inflammatory process increases in AD. However, the relationship of this inflammatory process with the severity and duration of the disease and drug use is still unknown.Öğe Can the systemic immune-inflammatory index be a new indicator for the diagnosis and follow-up of alzheimer's disease?(2022) BOLAYIR,Aslı; KIRAN,Tuğba Raika; KARABULUT,Background: Alzheimer's disease (AD) is a chronic neurodegenerative disease whose prevalence continues to increase in the elderly population. It has been shown that the neutrophil/lymphocyte ratio (NLR), is increased in AD compared to the normal population. However, there is no study in the literature regarding the role of systemic immune-inflammatory index (SII), which is calculated according to the formula of peripheral platelet count X neutrophil count/lymphocyte count, in AD. Therefore, our aim in this study was to reveal the role of SII in the diagnosis and follow-up of AD and to determine the relationship of this value with severity, duration of disease and drug use by comparing it with NLR. Materials and Methods: Our retrospective study consisted of 94 gender and age matched healthy volunteers and 102 patients who applied to our clinic were diagnosed with AD. Results: There was no difference between the patient and control groups in terms of age, gender, platelet and neutrophil counts, and SII values. While lymphocyte count was lower in-patient group; NLR and CRP detected higher (p=0.001, p=0.001, p=0.001, respectively). While SII increased as both disease duration and severity elevated; no statistically significant correlation was found between NLR and the severity and duration of the disease and drug use. Conclusions: Based on the data of our study, we can suggest that inflammatory process increases in AD. However, the relationship of this inflammatory process with the severity and duration of the disease and drug use is still unknown.Öğe ÖĞRENCİLERİN ANOTOMİ DERSİNE AYIRDIKLARI ZAMAN İLE ANOTOMİ DERSİ HAKKINDAKİ GÖRÜŞLERİNİN İLİŞKİSİNİN DEĞERLENDİRİLMESİ(MTÜ, 2022) UZUN BAĞCI,Gökçe; ARPACI,Muhammed Furkan; KAYA,Anıl; AYDIN,MerveAmaç: Anatomi dersinin klinikte, hastayı anlamak ve diğer dersleri kavrayabilmek için temel derslerden biri olması nedeniyle hem öğretim elemanları için hem de öğrenciler için önemli bir yere sahiptir. Öğrencilerin Anatomi dersinin dilinin Latince olması, ders öğreniminde zorluk yaşanmasına neden olmaktadır. Çalışmamızın amacı; öğrencilerin Anatomi dersi ile ilgili görüşlerini değerlendirerek öğrencilerin dersi daha iyi anlayabilmeleri için öğrencilere faydalı olunması amaçlanmıştır. Materyal ve Metot: Çalışmamız; Malatya Turgut Özal Üniversitesi’nde eğitim-öğretim gören; Hemşirelik Bölümü, Beslenme ve Diyetetik Bölümü, Tıbbi Laboratuvar Teknikleri Programı öğrencilerinden 113 kız, 19 erkek, toplam 132 kişi üzerinde gerçekleştirildi. Öğrencilerimize Anatomi dersi hakkında görüşlerinin olduğu demografik sorularla birlikte 15 sorudan oluşan bir form uygulanarak öğrencilerin görüşleri değerlendirildi. Bulgular: Öğrencilerin %97’si ‘‘Anatomi dersini veren hoca önemlidir” derken, %87.9 “Anatomi dersinde laboratuvara katılmak bizi mutlu ediyor.’’ cevabını vermiştir. ‘‘Anatomi dersine çalışmak neden çok vakit alıyor?’’ sorusuna %87.1’i ‘‘Latince ve ben ilk defa görüyorum.’’ demiştir. ‘‘Anatomi dersinde öğrencilerin kazanımlarının artırılması için önerileriniz nelerdir?’’ sorusuna %43.9’u ‘‘fikrim yok’’ cevabını verirken, %28’i ‘‘Laboratuvar dersi daha çok yapılmalı’’, %15.9’u ‘‘Anatomi konuları azaltılmalı ve bol kelime tekrarı yapılmalı”, %6.1’i “Anatomi dersinde daha çok görseller kullanılmalı’’ cevabını vermiştir. Sonuç: Çalışmamızda; öğrencilerin görüşleri değerlendirilerek, sonuçların hem öğrencilere ve hem de ders veren öğretim elemanlarına ve ayrıca araştırmacılara katkı sağlayacağı kanaatindeyiz.Öğe Tedaviyle ortaya çıkan santral uyku apnesi (Te-Csa)(MTÜ, 2022) ALTINTOP GEÇGİL, AyşegülTedaviyle ortaya çıkan santral uyku apnesi (TE-CSA), obstrüktif uyku apne (OSA) tanısı ile tedavi başlanan hastalarda, tedavi sürecinde obstrüktif apneler kontrol altına alınmasına rağmen, santral uyku apnesinin (CSA) ortaya çıkmasıdır. OSA hastalarının yaklaşık %2-20’sinde TE-CSA görülmekte olup TE-CSA prevalansı kardiyak komorbiditeleri olan hastalarda daha yüksektir. TE-CSA hastalarında, uygun tedavi seçilmediği takdirde, klasik OSA'lı hastalara kıyasla pozitif havayolu basınç (PAP) tedavisi kullanımının ve tedavi uyumunun zayıf olduğu saptanmıştır. TE-CSA tanılı hastaların değerlendirilmesi ve uygun tedavilerin başlanması, uykuda solunum bozukluğu olan hastalarda, semptom kontrolünü ve yaşam kalitesini iyileştirebilir.Öğe Near-total posterior capsulotomy in congenital cataract surgery: a novel surgical approach(MTÜ, 2022) GÜNDÜZ,Abuzer; ÖZTÜRK,Emrah; OZSOY,ErcanBackground: To define near-total posterior capsulotomy instead of partial posterior capsulotomy with lens aspiration and anterior vitrectomy in congenital cataract surgery. Materials and Methods: The research was carried out in a tertiary care center. Eleven patients who underwent near-total posterior capsulotomy, lens aspiration, and anterior vitrectomy surgery for treatment of congenital cataract between January 2010 and September 2018 were included in the study. Lenticular leukocoria was accepted as an indication for surgery. Patients who were older than six months at diagnosis and had a follow-up time of less than six months were excluded from the research. Surgical success was defined as the presence of a clear central visual axis in postoperative 6th months. Results: The study included 22 eyes from 11 cataract surgery patients due to congenital cataracts. Both eyes of all patients underwent surgery in the same session. At the time of diagnosis, the average age of the patients was 2.89 ± 1.8 months, and at the time of surgery, the mean age of the patients was 3.70 ± 1.84 months. The average follow-up time was 16.54 ± 14.96 (8-48) months. Intraoperative complications did not occur in any patient. Visual axis opacification was not observed in any patient during the follow-up. Conclusions: Near-total posterior capsulotomy is an easy and safe surgical technique. It could reduce the visual axis opacification.Öğe Near-total posterior capsulotomy in congenital cataract surgery: a novel surgical approach(MTÜ, 2022) GÜNDÜZ,Abuzer; ÖZTÜRK,Emrah; OZSOY,ErcanBackground: To define near-total posterior capsulotomy instead of partial posterior capsulotomy with lens aspiration and anterior vitrectomy in congenital cataract surgery. Materials and Methods: The research was carried out in a tertiary care center. Eleven patients who underwent near-total posterior capsulotomy, lens aspiration, and anterior vitrectomy surgery for treatment of congenital cataract between January 2010 and September 2018 were included in the study. Lenticular leukocoria was accepted as an indication for surgery. Patients who were older than six months at diagnosis and had a follow-up time of less than six months were excluded from the research. Surgical success was defined as the presence of a clear central visual axis in postoperative 6th months. Results: The study included 22 eyes from 11 cataract surgery patients due to congenital cataracts. Both eyes of all patients underwent surgery in the same session. At the time of diagnosis, the average age of the patients was 2.89 ± 1.8 months, and at the time of surgery, the mean age of the patients was 3.70 ± 1.84 months. The average follow-up time was 16.54 ± 14.96 (8-48) months. Intraoperative complications did not occur in any patient. Visual axis opacification was not observed in any patient during the follow-up. Conclusions: Near-total posterior capsulotomy is an easy and safe surgical technique. It could reduce the visual axis opacification.
