Preparation of 10-undecenoic acid based polyurethane/PCL fibers by electrospinning method and investigation of their antifungal properties

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dc.authorid0000-0001-6783-7030en_US
dc.contributor.authorAçarı Karaca, İdil
dc.contributor.authorBoran, Filiz
dc.contributor.authorKolak, Seda
dc.contributor.authorTatlıcı, Eray
dc.contributor.authorYeşilada, Özfer
dc.contributor.authorKöytepe, Süleyman
dc.contributor.authorAteş, Burhan
dc.date.accessioned2022-07-21T07:39:48Z
dc.date.available2022-07-21T07:39:48Z
dc.date.issued2022en_US
dc.departmentMTÖ Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, Biyomühendislik Bölümüen_US
dc.descriptionReceived: 2 April 2022 / Revised: 2 June 2022 / Accepted: 8 June 2022en_US
dc.description© The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022en_US
dc.descriptionİdil Karaca Açarı, Department of Bioengineering, Faculty of Engineering and Natural Sciences, Malatya Turgut Ozal University, Malatya, 44210, Turkey. Filiz Boran, Department of Chemistry, Faculty of Science, Inonu University, Malatya, 44280, Turkey. Seda Kolak, Department of Biology, Faculty of Science, Inonu University, Malatya, 44280, Turkey. Eray Tatlıcı, Department of Biology, Faculty of Science, Inonu University, Malatya, 44280, Turkey. Özfer Yeşilada, Department of Biology, Faculty of Science, Inonu University, Malatya, 44280, Turkey. Süleyman Köytepe, Department of Chemistry, Faculty of Science, Inonu University, Malatya, 44280, Turkey. Burhan Ateş, Department of Chemistry, Faculty of Science, Inonu University, Malatya, 44280, Turkey.en_US
dc.description.abstractNowadays, in the treatment of such fungal infections, antifungal drugs in various forms are one of the most preferred methods. These medications can be in the form of creams and lotions, shampoos, pills, suppositories, powders, or sprays. The dose of the drugs is adjusted according to the type and growth area of the fungus, the severity of the symptoms, and the medical history of the patients. Dressing materials with antifungal properties are an alternative treatment method used for the treatment of fungal skin infections. These covers not only treat fungal infections but also prevent their spread. Within the scope of this study, polyurethane-based wound dressing materials (PU-UDA/PCL) with antifungal properties were developed. Electrospining method was used to produce these dressing materials and the surface area of the wound dressing material was increased, thereby increasing the effect of antifungal property. Polypropylene glycol, glycerol, and catechin as polyol were preferred in polyurethane (PU) synthesis. These structures were polymerized with isophorone diisocyanate and modified with 10-undecenoic acid. Obtained 10-undecenoic acid modified polyurethane (PU-UDA) structures were transformed into wound dressing structure with polycaprolactone (PCL) by electrospinning method. Structural, morphological, and thermal properties of the wound dressing materials were analyzed with different instrumental analysis methods. The antifungal activities of PU-UDA/PCL were tested. Antifungal tests were performed on C. albicans and C. tropicalis. Therefore, PU-UDA/PCL series could be used as an efficient antifungal agent. Finally, it was determined that the obtained 10-undecenoic acid-based polyurethane fibers have a suitable structure and feature for the treatment of many fungal infections.en_US
dc.identifier.citationAçarı, İ. K., Boran, F., Kolak, S., Tatlıcı, E., Yeşilada, Ö., Köytepe, S., & Ateş, B. (2022). Preparation of 10-undecenoic acid based polyurethane/PCL fibers by electrospinning method and investigation of their antifungal properties. Polymer Bulletin, 1-19.en_US
dc.identifier.doi10.1007/s00289-022-04322-y
dc.identifier.endpage19en_US
dc.identifier.issn0170-0839en_US
dc.identifier.issn1436-2449en_US
dc.identifier.scopus2-s2.0-85132882037en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://doi.org/10.1007/s00289-022-04322-y
dc.identifier.urihttps://hdl.handle.net/20.500.12899/1164
dc.identifier.wosWOS:000817011700001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorAçarı Karaca, İdil
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofPolymer Bulletinen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPolyurethaneen_US
dc.subjectWound dressing materialen_US
dc.subjectAnti-fungal propertyen_US
dc.titlePreparation of 10-undecenoic acid based polyurethane/PCL fibers by electrospinning method and investigation of their antifungal propertiesen_US
dc.typeArticleen_US

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