A potential association between the number of CA repeats in the promoter region of the ADAMTS9 gene with lymphatic metastasis of breast cancer

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dc.authoridTopcu, Vehap/0000-0001-6881-3284|acar, muradiye/0000-0003-4357-5229|Topcu, Vehap/0000-0001-7224-5697;
dc.contributor.authorBozer, Mikdat
dc.contributor.authorAsik, Fatma
dc.contributor.authorAcar, Muradiye
dc.contributor.authorHaltas, Hacer
dc.contributor.authorYenidunya, Sibel
dc.contributor.authorCanbal, Metin
dc.contributor.authorTopcu, Vehap
dc.date.accessioned2025-10-24T18:09:49Z
dc.date.available2025-10-24T18:09:49Z
dc.date.issued2013
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractAim: We investigated the effect of the number of cytosine-adenine (CA) repeats in the ADAMTS9 promoter region on breast cancer lymphatic metastasis. Materials and methods: Thirty-one postoperative breast cancer patients were selected and examined retrospectively. The patients were classified into 2 groups: metastatic or nonmetastatic. Thirty healthy women were selected as the control group, and their peripheral blood was obtained. Following DNA isolation from the cancer tissue specimens and peripheral blood, the promoter region of the ADAMTS9 gene was directly sequenced and the number of CA repeats was determined. Results: The number of CA repeats ranged between 19 and 21 in the control and metastatic groups. However, in the nonmetastatic group, the number of CA repeats ranged between 17 and 18. This difference in the median number of CA repeats between the control group and the nonmetastatic group was statistically significant. Conclusion: A potential relationship may exist between lymphatic metastasis in breast cancer and the number of CA repeats in the promoter region of the ADAMTS9 gene. Our study indicates a potential association between the number of CA microsatellite repeats in the promoter region of the ADAMTS9 gene and breast cancer lymphatic metastasis.
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [3501-110S479]; Japan Society for the Promotion of Science (JSPS); Japan Takeda Science Foundation; MONBUSHO (Japan Ministry of Education); Turgut Ozal University School of Medicine, Scientific Research Project Office
dc.description.sponsorshipThis work was supported by grant 3501-110S479 from the Scientific and Technological Research Council of Turkey (TUBITAK) to K Demircan. Dr Demircan also thanks the Japan Society for the Promotion of Science (JSPS), the Japan Takeda Science Foundation, and MONBUSHO (Japan Ministry of Education) for grants during his doctoral and postdoctoral fellowship. F Asik was supported by a grant from the Turgut Ozal University School of Medicine, Scientific Research Project Office. Dr Demircan would also like to thank Dr Yoshifumi Ninomiya (Japan, pioneer of collagen and extracellular matrix works) and Dr Suneel Apte (USA, pioneering scientist of ADAMTS) for their excellent mentoring, encouragement of junior scientists, and technical support.
dc.identifier.doi10.3906/sag-1210-84
dc.identifier.endpage677
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue5
dc.identifier.scopus2-s2.0-84882973706
dc.identifier.scopusqualityQ1
dc.identifier.startpage671
dc.identifier.trdizinid211685
dc.identifier.urihttps://doi.org/10.3906/sag-1210-84
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/211685
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3853
dc.identifier.volume43
dc.identifier.wosWOS:000323610400001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR
dc.language.isoen
dc.publisherTubitak Scientific & Technological Research Council Turkey
dc.relation.ispartofTurkish Journal Of Medical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20251023
dc.subjectBreast cancer; lymphatic metastasis; ADAMTS9 gene; promoter region; dinucleotide repeats
dc.titleA potential association between the number of CA repeats in the promoter region of the ADAMTS9 gene with lymphatic metastasis of breast cancer
dc.typeArticle

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