The Relationship Between Anxiety and Adverse Events During Hematopoietic Stem Cell Transplantation in Cancer Patients: A Cross-Sectional Study

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dc.contributor.authorErturk, Nuriye Efe
dc.contributor.authorMenekli, Tugba
dc.date.accessioned2026-06-19T06:37:57Z
dc.date.available2026-06-19T06:37:57Z
dc.date.issued2024
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractObjective Anxiety, negatively affects the response to transplantation and the recovery process after transplantation. Anxiety prevalence is high pre and post transplantation but no information is known about during transplantation. This study was conducted to determine anxiety and adverse events during hematopoietic stem cell transplantation (HSCT) and to explain the association between these two conditions. Methods The sample consisted of 93 patients with cancer who received hematopoietic stem cell transplantation at the Bone Marrow Transplant Centre in Turkiye. The data were collected using a patient information form and the State Anxiety Inventory (STAI-S). Significance between the descriptive characteristics of the participants and the scale was calculated using a one-way ANOVA and Student -T test. Logistic regression analysis was performed to determine the effect of adverse events on the level of anxiety. Results We found that there was a significant difference between the variables of age (F = 2.497 p = 0.020), gender, years after diagnosis (F= 1.381 p = 0.035), the state of believing that transplant will be successful and previous transplant history, and the STAI-S mean score. The Nagelkerke R2 value of the model was 0.167. The goodness of fit of the model was assessed using Hosmer and Lemeshow's test (X2= 8.900, p = 0.203). When analyzing the adverse events during HSCT that affected the occurrence of anxiety, we found that nausea and vomiting increased the anxiety score by 6.1 -fold (6: 0.613, p = 0.010), abdominal pain by 4.4 -fold (6: 0.449, p = 0.030), and tachycardia by 2.6 -fold (6: 0.267, p = 0.020). Conclusions The results of this study showed that patients experienced nausea and vomiting, hypertension and abdominal pain during stem cell transplantation, respectively; anxiety level was above the moderate level; nausea and vomiting, abdominal pain and palpitations increased anxiety. Preventing anxiety during stem cell transplant can reduce adverse effects depend on HSCT.
dc.identifier.doi10.3329/bjms.v23i2.72166
dc.identifier.endpage454
dc.identifier.issn2223-4721
dc.identifier.issn2076-0299
dc.identifier.issue2
dc.identifier.scopus2-s2.0-85189333533
dc.identifier.scopusqualityQ2
dc.identifier.startpage447
dc.identifier.urihttps://doi.org/10.3329/bjms.v23i2.72166
dc.identifier.urihttps://hdl.handle.net/20.500.12899/5309
dc.identifier.volume23
dc.identifier.wosWOS:001195150500028
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherIbn Sina Trust
dc.relation.ispartofBangladesh Journal of Medical Science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20260612
dc.subjectHematopoietic Stem Cell Transplant
dc.subjectAnxiety
dc.subjectAdverse Events
dc.subjectNursing
dc.titleThe Relationship Between Anxiety and Adverse Events During Hematopoietic Stem Cell Transplantation in Cancer Patients: A Cross-Sectional Study
dc.typeArticle

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