The Effects of Honeybee Venom Intoxication on the Cardiovascular System in Rats

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dc.contributor.authorSahin, Levent
dc.contributor.authorMakav, Mustafa
dc.contributor.authorDolanbay, Turgut
dc.contributor.authorDag, Serpil
dc.contributor.authorYildiz, Ayfer
dc.date.accessioned2026-06-19T06:40:54Z
dc.date.available2026-06-19T06:40:54Z
dc.date.issued2025
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractObjectiveThe objective of this study was to examine the effects of bee venom (BV), which contains many enzymes, peptides, and amines, on the cardiovascular system in rats.Materials and MethodsThe animal material of the study included 24 Wistar albino rats in total, divided into the control, low dose (20 mu g/g-mg/kg) BV, and high dose (30 mu g/g-mg/kg) BV groups. Heart rate, PR, QRS, and QTc interval values were recorded in the electrocardiography (ECG) examinations of the rats. Blood samples were collected for biochemical analyses, and heart tissue samples were collected for histopathological analyses.ResultsAccording to the ECG data, heart rate values decreased at the 6th h in both the 20 and 30 mg BV groups. The PR interval value increased at the 6th h in both the 20 and 30 mg BV groups in comparison to the control group. Compared to the control group, the troponin and creatine kinase (CK) values of the 20 and 30 mg BV groups significantly increased. Furthermore, creatine kinase myocardial band (CK-MB) and lactate dehydrogenase (LDH) values increased in both the 20 and 30 mg BV groups compared to the control group. Heart tissues taken from both groups administered BV were hyperemic, and hemorrhagic areas were detected in the heart tissues of some rats in the group administered 30 mg BV.ConclusionBV has a dose-independent bradycardic effect and increases cardiac enzymes while adversely affecting heart tissue at high doses.
dc.description.sponsorshipKafkas University
dc.description.sponsorshipNone
dc.identifier.doi10.1007/s44411-025-00143-3
dc.identifier.endpage1338
dc.identifier.issn0006-9248
dc.identifier.issn1336-0345
dc.identifier.issue7
dc.identifier.scopus2-s2.0-105002460109
dc.identifier.scopusqualityQ2
dc.identifier.startpage1332
dc.identifier.urihttps://doi.org/10.1007/s44411-025-00143-3
dc.identifier.urihttps://hdl.handle.net/20.500.12899/5965
dc.identifier.volume126
dc.identifier.wosWOS:001466224900001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherSpringernature
dc.relation.ispartofBratislava Medical Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20260612
dc.subjectBee Venom
dc.subjectCardiovascular System
dc.subjectIntoxication
dc.subjectEcg
dc.subjectRat
dc.titleThe Effects of Honeybee Venom Intoxication on the Cardiovascular System in Rats
dc.typeArticle

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