Antiproliferative effects of cadmium sulfide nanoparticles obtained from walnut shells by green synthesis method on SH-SY5Y cell line

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dc.contributor.authorYeni, Yesim
dc.contributor.authorNadaroglu, Hayrunnisa
dc.contributor.authorErtugrul, M. Sait
dc.contributor.authorHacimuftuoglu, Ahmet
dc.contributor.authorAlayli, Azize
dc.date.accessioned2026-06-19T06:31:55Z
dc.date.available2026-06-19T06:31:55Z
dc.date.issued2024
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractNanoparticles are attracting attention for their potential therapeutic applications, particularly in cancer therapy, underscoring their importance in medicine. Cadmium sulfide nanoparticles, known for their robust catalytic and optical properties, are classified as chalcogenides and show promise for cancer diagnosis and treatment. Neuroblastoma, a common solid tumor in childhood, poses a significant health threat with different outcomes depending on its biological subtype. This study evaluated the antiproliferative effects of cadmium sulfide nanoparticles on the SY-SH5Y cell line. Walnut shell extract and Na2S were used to facilitate the synthesis of cadmium sulfide nanoparticles by green synthesis. Characterization of the synthesized cadmium sulfide nanoparticles was performed by Fourier transform infrared spectroscopy, scanning electron microscopy, and x-ray diffraction analyses. The SH-SY5Y cell line was cultured in a standard cell culture medium and then exposed to different cadmium sulfide nanoparticles (10–25–50–75–100 µg/mL) for 24 hours. Cell viability, oxidant, and antioxidant levels were then assessed using a 3-(4,5-dimetiltiyazol-2-il)-2,5-difeniltetrazolyum bromür, total antioxidant, and total oxidant assays. The data showed that applying 100 μg/mL cadmium sulfide nanoparticles resulted in a significant decrease in cancer cell viability of up to 40.96 % (p<0.05). The cadmium sulfide nanoparticles had a dose-dependent effect on the SH-SY5Y cell line. Furthermore, cadmium sulfide nanoparticles increased oxidative activity in neuroblastoma cells, which was consistent with the results of the 3-(4,5-dimetiltiyazol-2-il)-2,5-difeniltetrazolyum bromür assay. In conclusion, cadmium sulfide nanoparticles exhibited potent activity against the neuroblastoma cell. This study highlights the antiproliferative efficacy of green-synthesized cadmium sulfide nanoparticles with walnut shell extract on relevant cancer cell lines. © 2024 The Authors
dc.identifier.doi10.1016/j.toxrep.2024.101818
dc.identifier.issn2214-7500
dc.identifier.scopus2-s2.0-85209732198
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.toxrep.2024.101818
dc.identifier.urihttps://hdl.handle.net/20.500.12899/4864
dc.identifier.volume13
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier Inc.
dc.relation.ispartofToxicology Reports
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_Scopus_20260612
dc.subjectAntioxidant
dc.subjectCadmium Sulfide Nanoparticles
dc.subjectGreen Synthesis
dc.subjectNeuroblastoma
dc.subjectSy-Sh5Y
dc.subjectWalnut Shell Extract
dc.titleAntiproliferative effects of cadmium sulfide nanoparticles obtained from walnut shells by green synthesis method on SH-SY5Y cell line
dc.typeArticle

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