Antioxidant and cytotoxic properties of some new dipeptide-indole conjugates

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dc.contributor.authorGonul, Zeynep
dc.contributor.authorOzturk, Dilara Altay
dc.contributor.authorKucukbay, Fatumetuzzehra
dc.contributor.authorTekin, Suat
dc.contributor.authorTekin, Zehra
dc.contributor.authorKucukbay, Hasan
dc.date.accessioned2026-06-19T06:41:17Z
dc.date.available2026-06-19T06:41:17Z
dc.date.issued2023
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractIn this study, 10 new indole-dipeptide conjugates were synthesized, and their anticancer activity was determined against on A2780 (ovarian cancer cell line) and MCF-7 (breast cancer cell line) cells. Among compounds, 5 and 10 showed better activity against A2780 cell lines than the standard drug docatexel at 0.1 and 1 mu M concentrations, while only compound 5 showed better activity than docatexel, the MCF-7 cell line at 0.1 and 1 mu M concentrations. The antioxidant potencies of the compounds were low in both the DPPH and iron reducing power methods tested when compared to standard antioxidants used in this work.
dc.description.sponsorshipInonu University, Turkey [FOA-2020-2203]
dc.description.sponsorshipInonu University, Turkey, Grant/Award Number: FOA-2020-2203
dc.identifier.doi10.1002/jhet.4564
dc.identifier.endpage95
dc.identifier.issn0022-152X
dc.identifier.issn1943-5193
dc.identifier.issue1
dc.identifier.orcid0000-0003-3682-3044
dc.identifier.orcid0000-0003-1126-7416
dc.identifier.scopus2-s2.0-85137595024
dc.identifier.scopusqualityQ2
dc.identifier.startpage86
dc.identifier.urihttps://doi.org/10.1002/jhet.4564
dc.identifier.urihttps://hdl.handle.net/20.500.12899/6173
dc.identifier.volume60
dc.identifier.wosWOS:000849881000001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofJournal of Heterocyclic Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20260612
dc.subject[Keyword Not Available]
dc.titleAntioxidant and cytotoxic properties of some new dipeptide-indole conjugates
dc.typeArticle

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