Determining the role of HLA-B27 on COVID-19

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dc.contributor.authorKarahan, Doğu
dc.contributor.authorDemir, Bilgehan
dc.date.accessioned2025-10-24T18:04:10Z
dc.date.available2025-10-24T18:04:10Z
dc.date.issued2023
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractAim: Human leukocyte antigen-B27 (HLA-B27) binds antigenic peptides in the structure of some viruses and presents them to cytotoxic T lymphocytes and plays a role in the immune response against these viruses. It has also been found to be associated with auto-immunity as an inverse relationship and is associated with a number of auto-immune inflammatory diseases, especially Ankylosing Spondylitis (AS). Our aim in this study is to determine the role of HLA-B27 in Severe Acute Respiratory Syndrome (SARS)-Cov-2 (Coronavirus Disease-COVID-19). Materials and Methods: 90 HLA-B27 positive and 96 HLA-B27 negative cases were included in the study. COVID-19 Polymerase Chain Reaction (PCR) results and Thorax Computed Tomography (CT) results, hospitalization and death records of the cases were retrospectively analyzed from the system records. Results were compared between HLA B27 positive and negative groups. Results: Of the HLA-B27 positive cases, 32.2% had COVID-19 positivity, 5.6% had COVID-19 lung involvement. 44.8% of HLA-B27 negative cases had COVID-19 positivity and 11.5% had lung involvement. There was no significant difference between the HLA-B27 positive and negative groups in terms of having COVID-19 infection, lung involvement, hospitalization and death rates. Conclusion: The results of our study show that HLA-B27 does not have a protective role in terms of having COVID-19 and lung involvement. Again, since no auto-immunity related SARS was observed in any of the patients, it can be said that it did not increase the severity of the hyper-immunity-related disease and did not increase the risk of death in particular for COVID-19. These results need to be supported by more studies.
dc.identifier.doi10.5455/annalsmedres.2022.10.306
dc.identifier.endpage433
dc.identifier.issn2636-7688
dc.identifier.issue4
dc.identifier.startpage428
dc.identifier.trdizinid1164948
dc.identifier.urihttps://doi.org/10.5455/annalsmedres.2022.10.306
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1164948
dc.identifier.urihttps://hdl.handle.net/20.500.12899/2692
dc.identifier.volume30
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofAnnals of Medical Research
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzTR-Dizin_20251023
dc.subjectKlinik Nöroloji
dc.subjectMikrobiyoloji
dc.subjectSağlık Bilimleri ve Hizmetleri
dc.subjectİmmünoloji
dc.subjectPsikiyatri
dc.subjectCOVID-19
dc.subjectHLA B27
dc.subjectAuto-immunity
dc.titleDetermining the role of HLA-B27 on COVID-19
dc.typeArticle

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