Impairment of Glucose Tolerance Test During Pregnancy and Serum Assymmetric Dimethylarginine Levels

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dc.contributor.authorFindik, Rahime Bedir
dc.contributor.authorCelik, Huseyin Tugrul
dc.contributor.authorYilmaz, Fatma Meric
dc.contributor.authorYilmaz, Hinc
dc.contributor.authorAbusoglu, Sedat
dc.date.accessioned2025-10-24T18:10:00Z
dc.date.available2025-10-24T18:10:00Z
dc.date.issued2016
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractAim: Assymetric dimethylarginin (ADMA), an inhibitor of nitric oxide synthase (NOS), has been linked to endothelial dysfunction. Our aim in this study was to compare ADMA and arginine levels in normal glucose tolerance, impaired glucose tolerance and gestational diabetes groups and investigate the effect on baby birth weight. Material and Method: Serum ADMA and arginine levels were investigated in 64 patients whose 50-g glucose loading test was normal (group 1, NGT); 33 patients whose 50-g test result was high and those whose 100-g oral glucose tolerance test (OGTT) was normal, namely, those with impaired glucose tolerance (IGT, group 2); and in 8 patients diagnosed with gestational diabetes mellitus (GDM, group 3). Results: Arginine levels were significantly higher in the IGT group than in the NGT group. ADMA levels were high in the GDM group, but the difference was not statistically significant. There were a statistically significant correlation between arginine and ADMA levels and the ADMA level of those with a diabetes history. No significant relationship was found between ADMA level, arginine and the weight of the infant. Discussions: Although there has not been a clinical status related with nitric oxide deficiency caused by increasing ADMA concentrations, pregnancies with increased body mass indeks (BMI), family history for diabetes and older ages should be carefully monitorized. ADMA tends to increase in patients with IGT and GDM. In addition, blood ADMA and arginine levels do not seem to influence the weight of the infant.
dc.identifier.doi10.4328/JCAM.2657
dc.identifier.endpage303
dc.identifier.issn1309-0720
dc.identifier.issn1309-2014
dc.identifier.issue3
dc.identifier.scopus2-s2.0-84954061948
dc.identifier.scopusqualityN/A
dc.identifier.startpage300
dc.identifier.urihttps://doi.org/10.4328/JCAM.2657
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3939
dc.identifier.volume7
dc.identifier.wosWOS:000376566800004
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherDerman Medical Publ
dc.relation.ispartofJournal Of Clinical And Analytical Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20251023
dc.subjectAsymmetric Dimethylarginine; Gestational Diabetes; Impaired Glucose Tolerance; Endothelial Dysfunction; Arginine
dc.titleImpairment of Glucose Tolerance Test During Pregnancy and Serum Assymmetric Dimethylarginine Levels
dc.title.alternativeGebelikte bozulmuş glukoz tolerans testi ve serum asimetrik dimetil arjinin düzeyleri
dc.typeArticle

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