PTZ KINDLING MODEL: EVALUATION OF EEG FACTOR AND BIOCHEMISTRY PARAMETERS UNDER THE INFLUENCE OF RAMELTEON

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dc.contributor.authorPala, Mukaddes
dc.contributor.authorkozan, ramazan
dc.contributor.authorKose, Hayrullah
dc.contributor.authorYılmaz, Şenay Görücü
dc.date.accessioned2025-10-24T18:03:51Z
dc.date.available2025-10-24T18:03:51Z
dc.date.issued2024
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractMany selective synthetic melatonin receptor agonists have anticonvulsant/anti-epileptogenic properties. These agonists bind to melatonin receptor 1 (MT1) and receptor 2 (MT2), causing their activation. Therefore, we evaluated the anticonvulsant effect of Ramelteon (RMLT) as a melatonin agonist in the PTZ (Pentylenetetrazol)-kindling model. In the study, 36 male Wistar Albino rats were assessed in 6 groups (Sham, PTZ, dimethylsulphoxide (DMSO), Valproic acid (VPA) (150 mg/kg) + PTZ, RMLT (30 mg/kg)+PTZ, VPA+RMLT+PTZ). Cortical electroencephalography (EEG) data were recorded for all groups. Seizures were scored according to the Racine scale. Seizure scores and onset times of the first myoclonic movements were compared in EEG traces. Total antioxidant status (TAS), total oxidant status (TOS), catalase, myeloperoxidase (MPO), and Thiol levels were measured in serum samples. Also, Calcineurin (CaN), Neuropeptide-Y (NPY), Neuron Specific Enolase (NSE), and S100B levels were measured in brain tissue samples. There was a significant difference between the PTZ and PTZ+Valproic acid+RMLT groups for the onset of the first myoclonic movements and the rate of spikes in the EEG traces in Racine's convulsion stages (P 0.05). RMLT has anticonvulsant properties. Additionally, the receptor preference of RMLT can be investigated.
dc.identifier.doi10.33715/inonusaglik.1495324
dc.identifier.endpage859
dc.identifier.issn2147-7892
dc.identifier.issue3
dc.identifier.startpage843
dc.identifier.trdizinid1278437
dc.identifier.urihttps://doi.org/10.33715/inonusaglik.1495324
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1278437
dc.identifier.urihttps://hdl.handle.net/20.500.12899/2499
dc.identifier.volume12
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofİnönü üniversitesi Sağlık Hizmetleri Meslek Yüksek Okulu Dergisi
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzTR-Dizin_20251023
dc.subjectEpilepsy
dc.subjectElectroencephalography
dc.subjectPentylenetetrazole
dc.subjectAnticonvulsant effect
dc.subjectRamelteon.
dc.titlePTZ KINDLING MODEL: EVALUATION OF EEG FACTOR AND BIOCHEMISTRY PARAMETERS UNDER THE INFLUENCE OF RAMELTEON
dc.typeArticle

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