Investigation of Acrylamide Based Hydrogels as L-Dopa and L-Tyrosine Drug Release System

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dc.contributor.authorAcari, Idil Karaca
dc.date.accessioned2026-06-19T06:37:31Z
dc.date.available2026-06-19T06:37:31Z
dc.date.issued2022
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractAcrylamide-based hydrogels exhibit significant volume migration in response to physical and chemical stimuli. These properties make their use as drug delivery systems widespread. In the study, acrylamide-based hydrogel structures were synthesized to be used as two prodrugs known as L-Dopa and L-Tyrosine carrier and release system. Fourier-transform infrared (FTIR) spectroscopy, scanning electron micrography (SEM), Image J program were used to evaluate the structure-property relationship of the synthesized hydrogels and swelling studies were performed. The maximum swelling capacity of the synthesized hydrogel structures was determined as 973.80 +/- 12.25 %. The L-Dopa loading on the hydrogel was 69.51 +/- 9.64% and the L-Tyrosine loading was 61.37 +/- 5.08%. The release behavior of the drugs loaded on the hydrogel was monitored using a UV-vis spectrophotometer at pH 7.4 and lambda(max) 280 nm. Accordingly, it was observed experimentally that 84.21 +/- 1.71% of L-Dopa and 75.98 +/- 2.69% of L-Tyrosine were released. The study is an alternative release system with the simultaneous release of L-Dopa molecule, which is especially used in the treatment of Parkinson's disease, and L-Tyrosine, which plays an important role in the synthesis of L-Dopa.
dc.identifier.doi10.52568/001076/JCSP/44.04.2022
dc.identifier.endpage392
dc.identifier.issn0253-5106
dc.identifier.issue4
dc.identifier.scopus2-s2.0-85140004898
dc.identifier.scopusqualityQ4
dc.identifier.startpage382
dc.identifier.urihttps://doi.org/10.52568/001076/JCSP/44.04.2022
dc.identifier.urihttps://hdl.handle.net/20.500.12899/5078
dc.identifier.volume44
dc.identifier.wosWOS:000856662200010
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorAcari, Idil Karaca
dc.language.isoen
dc.publisherChem Soc Pakistan
dc.relation.ispartofJournal of the Chemical Society of Pakistan
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20260612
dc.subjectAcrylamide-Based Hydrogels
dc.subjectL-Dopa
dc.subjectL-Tyrosine
dc.subjectDrug Release System
dc.titleInvestigation of Acrylamide Based Hydrogels as L-Dopa and L-Tyrosine Drug Release System
dc.typeArticle

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