The effect of regularly performed moderate-intensity exercise program on thiol/disulfide homeostasis, and ischemia-modified albumin

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dc.contributor.authorPala, Mukaddes
dc.contributor.authorAltan, Mehmet
dc.contributor.authorHanikoglu, Ferhat
dc.contributor.authorneselioglu, salim
dc.contributor.authorEREL, Ozcan
dc.contributor.authorMetin, Gökhan
dc.date.accessioned2025-10-24T18:03:46Z
dc.date.available2025-10-24T18:03:46Z
dc.date.issued2022
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractAim: Thiol/disulfide homeostasis is an indicator of oxidative stress and antioxidant capacity. Ischemia-modified albumin (IMA) is an important marker for both oxidative stress and ischemia. We aimed to evaluate the possible effects of regularly performed moderate-intensity exercise on thiol/disulfide homeostasis, and IMA levels.Methods: Sprague Dawley rats were used. The study was composed of an Exercise group (EG, n=9) and Control group (CG, n=6). A 10-weeks swimming exercise was performed. Thiol/disulfide homeostasis measurement method was used in this study. IMA levels were measured by a cobalt-albumin binding method.Results: In the EG, total thiol levels were significantly higher compared to the CG (p<0.01). The disulfide/total thiol ratio was lower in the EG compared to the CG (p<0.01). We observed that there was a slight increase in IMA levels in EG (p=0.18). This increase was not statistically significant.Conclusion: Regularly performed moderate-intensity exercise has increased native and total thiol levels. Increase of thiol levels can prevent oxidative stress. Regularly performed moderate-intensity exercise programs appear to provide favourable effects on oxidative stress. 
dc.identifier.doi10.30565/medalanya.1055424
dc.identifier.endpage125
dc.identifier.issn2587-0319
dc.identifier.issue2
dc.identifier.startpage120
dc.identifier.trdizinid1216485
dc.identifier.urihttps://doi.org/10.30565/medalanya.1055424
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1216485
dc.identifier.urihttps://hdl.handle.net/20.500.12899/2435
dc.identifier.volume6
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofActa Medica Alanya
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzTR-Dizin_20251023
dc.subjectBiyoloji
dc.subjectTıbbi Araştırmalar Deneysel
dc.subjectHalk ve Çevre Sağlığı
dc.subjectOxidative stress
dc.subjectSwimming
dc.subjectischemia-modified albumin
dc.subjectthiol/disulfide homeostasis
dc.titleThe effect of regularly performed moderate-intensity exercise program on thiol/disulfide homeostasis, and ischemia-modified albumin
dc.typeArticle

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