EVALUATION OF ANTIOXIDANT POTENTIAL, ANTICHOLINESTERASE ACTIVITY AND ELEMENT CONTENT OF CHLOROPHYLLUM RHACODES SPECIES
Küçük Resim Yok
Tarih
2026
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Medical Univ Warsaw
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
In this study, antioxidant potential, anticholinesterase activity, and elemental contents of Chlorophyllum rhacodes were evaluated. In order to determine the antioxidant capacity, total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), DPPH radical scavenging activity, and FRAP ferric reducing power analyses were applied. According to the obtained results, the TAS value was determined as 3.125 +/- 0.060 mmol/L, the TOS value as 6.821 +/- 0.062 & micro;mol/L, the OSI value as 0.218 +/- 0.003, DPPH activity as 55.430 +/- 1.438 mg TE/g, and the FRAP value as 72.540 +/- 1.461 mg TE/g. These data revealed that C. rhacodes showed a significant level of antioxidant activity. In the evaluation of anticholinesterase activity, inhibitory effects against AChE and BChE enzymes were determined, and IC50 values were found as 94.330 +/- 1.536 & micro;g/mL and 128.397 +/- 1.556 & micro;g/mL, respectively. These results show that C. rhacodes exhibits limited inhibitory effect on these enzymes but may have a certain level of anticholinesterase potential. According to the results of elemental analysis, Cd (14.78 +/- 1.53), Cr (33.17 +/- 1.42), Mn (7.35 +/- 0.52), Cu (155.77 +/- 2.34), Fe (469.30 +/- 15.75), Pb (6.98 +/- 0.54), Ni (3.66 +/- 0.31) and Zn (76.18 +/- 2.25) mg/kg levels were detected in mushroom samples. In particular, it was observed that Cd and Cu levels were above the upper limits specified in the literature. This finding shows that C. rhacodes tends to accumulate some heavy metals and may be highly sensitive to environmental pollution. In conclusion, C. rhacodes exhibits a biologically remarkable profile with certain antioxidant and anticholinesterase activities and can also be considered as a potential indicator species in the biological monitoring of environmental metal exposure.
Açıklama
Anahtar Kelimeler
Chlorophyllum Rhacodes, Antioxidant Activity, Anticholinesterase, Heavy Metal, Elemental Analysis
Kaynak
Prospects in Pharmaceutical Sciences
WoS Q Değeri
Q3
Scopus Q Değeri
Cilt
24
Sayı
1
