Exploring Irisin and Nesfatin-1 in second trimester amniotic fluid: a comparative study of obese and normal weight pregnant women

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dc.contributor.authorERENLER, SEBNEM
dc.contributor.authorMELEKOGLU, RAUF
dc.contributor.authorKIRAN, TUGBA RAIKA
dc.contributor.authorİnceoğlu, Feyza
dc.date.accessioned2025-10-24T18:04:20Z
dc.date.available2025-10-24T18:04:20Z
dc.date.issued2024
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractObjective: Obesity is characterized by dysregulated adipokine production patterns, leading to low-grade inflammation. Irisin has been identified as a potential target for the treatment of diabetes and obesity. Nesfatin-1, another adipokine, plays a significant role in various metabolic processes, including glucose homeostasis. This study investigated the levels of the new generation adipokines, irisin and nesfatin-1, in the amniotic fluid during the second trimester of normal and obese pregnancies. Methods: Amniotic fluid samples were collected following established protocols. The first 2 mL portion of fluid obtained during amniocentesis was retained aAfter centrifugation at 1500 g for 10 minutes, the cell-free amniotic fluid was transferred to Eppendorf tubes and quantitative measurements of irisin and nesfatin-1 levels were performed using the Enzyme-Linked Immuno Sorbent Assay (ELISA) method. Results: Our results demonstrate, for the first time in the literature, the presence of irisin and nesfatin-1 in amniotic fluid. Additionally, we found that the levels of these adipokines were significantly lower in obese pregnant women compared to the control group (both p<0.05). Conclusion: Our results demonstrate, for the first time in the literature, the presence of irisin and nesfatin-1 in amniotic fluid. Additionally, we found that the levels of these adipokines were significantly lower in obese pregnant women compared to the control group (both p<0.05).
dc.identifier.doi10.59215/prn.24.0323005
dc.identifier.endpage207
dc.identifier.issn1305-3124
dc.identifier.issue3
dc.identifier.startpage198
dc.identifier.trdizinid1297949
dc.identifier.urihttps://doi.org/10.59215/prn.24.0323005
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1297949
dc.identifier.urihttps://hdl.handle.net/20.500.12899/2799
dc.identifier.volume32
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofPerinatal journal (Online)
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzTR-Dizin_20251023
dc.subject#DEĞER!
dc.titleExploring Irisin and Nesfatin-1 in second trimester amniotic fluid: a comparative study of obese and normal weight pregnant women
dc.typeArticle

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