Proprotein convertase subtilisin/kexin type 9 and apelin in fibromyalgia syndrome

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dc.contributor.authorTAŞ, NEVSUN PIHTILI
dc.contributor.authorBaykara, Rabia Aydogan
dc.contributor.authorKAMANLI, Ayhan
dc.contributor.authorGürbüz, Ali
dc.contributor.authorCÜRE, Erkan
dc.contributor.authorcure, medine cumhur
dc.contributor.authorErdem, Mehmet
dc.date.accessioned2025-10-24T18:04:05Z
dc.date.available2025-10-24T18:04:05Z
dc.date.issued2024
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractObjectives: This study aimed to investigate the potential roles of proprotein convertase subtilisin/ kexin type 9 (PCSK9) and apelin in the etiology of fibromyalgia syndrome (FS). Patients and methods: The retrospective study was conducted between May 2022 and February 2023. Fifty-eight female FS patients (mean age: 45.2±9.9 years; range, 25 to 66 years) and 30 age- and body mass index-matched control subjects (mean age: 43.1±9.9 years; range, 26 to 67 years) were included in the study. Apelin and PCSK9 levels of all individuals were measured using appropriate methods. Results: The levels of PCSK9 (173.2±62.2 vs. 75.1±44.1, p<0.001) and apelin (354.6±195.5 vs. 229.0±83.2, p<0.001) were significantly higher in patients with FS compared to the control group. A positive correlation was found between PCSK9 and apelin levels and various measures, including the Fibromyalgia Impact Questionnaire (FIQ), Symptom Severity Scale (SSS), Pittsburgh Sleep Quality Index (PSQI), and Beck Depression Inventory (BDI). Additionally, there was a positive correlation between apelin levels and FIQ, SSS, PSQI, Beck Anxiety Inventory, and BDI scores. The optimal cutoff value for PCSK9 in predicting FS was 110.0 ng/mL, with a sensitivity of 84.5% and specificity of 83.9% (area under the curve [AUC]=0.920, 95% confidence interval [CI]: 0.852-0.987, p<0.001). For apelin, the optimal cutoff value for predicting FS was 258.8 ng/L, with a sensitivity of 63.8% and specificity of 64.5% (AUC=0.732, 95% CI: 0.623–0.840, p<0.001). Conclusion: Our findings suggest that PCSK9 may play a role in FS etiology and potentially contribute to oxidative stress. Increased apelin levels may be a compensatory response to high oxidative stress, possibly leading to hyperalgesia. Both PCSK9 and apelin can be predictive markers for FS.
dc.identifier.doi10.46497/ArchRheumatol.2024.10462
dc.identifier.endpage383
dc.identifier.issn2148-5046
dc.identifier.issn2618-6500
dc.identifier.issue3
dc.identifier.startpage375
dc.identifier.trdizinid1273101
dc.identifier.urihttps://doi.org/10.46497/ArchRheumatol.2024.10462
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1273101
dc.identifier.urihttps://hdl.handle.net/20.500.12899/2614
dc.identifier.volume39
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofArchives of Rheumatology
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzTR-Dizin_20251023
dc.subject#DEĞER!
dc.titleProprotein convertase subtilisin/kexin type 9 and apelin in fibromyalgia syndrome
dc.typeArticle

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