The Role of Long Pentraxin 3 and Nuclear Factor Kappa Beta in Vitiligo Occurrence and Disease Severity

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dc.contributor.authorGencoglu, Sule
dc.contributor.authorKanat, Zekiye
dc.date.accessioned2026-06-19T06:38:26Z
dc.date.available2026-06-19T06:38:26Z
dc.date.issued2023
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractObjectives. To reveal the role of long pentraxin 3 (PTX3) and nuclear factor kappa beta (NF-kB) in vitiligo and their relationship with disease severity. Materials and Methods. The study groups consisted of a total of 54 patients, including 27 patients diagnosed with vitiligo and 27 healthy controls without any cutaneous disease. Patients with amelanotic, sharply demarcated, and chalk-white macular lesions were defined as vitiligo. The diagnosis of vitiligo was confirmed by Wood's lamp examination. No biopsies were taken from the lesions, and no additional laboratory testing was performed. Skin and hair pigmentations in lesions other than hands and feet were evaluated. Vitiligo grading was done using the largest macules overall. Spreading rates were evaluated in selected lesions with Wood's lamp. The long pentraxin 3 and NF-kB levels in serum samples of participants were measured by the ELISA method. Results. According to the Vitiligo European Task Force consensus 16 of 27, vitiligo patients were in the slow progressive phase, and 11 patients were in the active progressive phase. The serum PTX3 levels of the patients in the vitiligo group were found to be significantly higher than those of the control group (8.21 +/- 2.11 ng/ml vs. 6.76 +/- 1.90 ng/ml, < 0.03). Similarly, the serum NF-kB levels of the patients in the vitiligo group were significantly higher than those of the patients in the control group (15.03 +/- 3.45 ng/ml vs. 12.19 +/- 4.20 ng/ml, < 0.01). A positive and significant correlation was found between serum NF-kB and PTX3 (r = 0.677 and < 0.01). PTX3 and NF-kB levels were significantly higher in patients in the active progressive phase than in patients in the slow progressive phase. PTX3 and NF-kB values in the active progressive phase tended to be higher than those detected when the disease was in the slow progressive phase. Conclusions. High serum PTX3 and NF-kB levels in vitiligo are evidence of impaired proinflammatory activity and innate and adaptive immunity.
dc.identifier.doi10.1155/2023/6303637
dc.identifier.issn1396-0296
dc.identifier.issn1529-8019
dc.identifier.orcid0000-0001-9057-6625
dc.identifier.scopus2-s2.0-85177851725
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1155/2023/6303637
dc.identifier.urihttps://hdl.handle.net/20.500.12899/5535
dc.identifier.volume2023
dc.identifier.wosWOS:001107372900001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofDermatologic Therapy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20260612
dc.subject[Keyword Not Available]
dc.titleThe Role of Long Pentraxin 3 and Nuclear Factor Kappa Beta in Vitiligo Occurrence and Disease Severity
dc.typeArticle

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