Effects of various conditions related to circadian rhythm disturbances on plasma and erythrocyte lipids in rats: a peroxisomal perspective

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dc.contributor.authorOtlu, Hüsniye Gül
dc.contributor.authorUGUR, Yılmaz
dc.contributor.authorYıldız, Azibe
dc.contributor.authorErdoğan, Selim
dc.contributor.authorYologlu, Saim
dc.contributor.authorVardi, Nigar
dc.contributor.authorGüldür, Tayfun
dc.date.accessioned2025-10-24T18:03:48Z
dc.date.available2025-10-24T18:03:48Z
dc.date.issued2024
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractPurpose: Lipidomics studies of sleep restriction, which is known to be associated with circadian perturbations, revealed alterations in some plasma phospholipid levels including plasmalogens which are partly synthesized in liver peroxisomes. To this end it was aimed to investigate effects of various conditions known to cause circadian rhythm disturbances on various peroxisomal parameters and to compare those effects with that of fenofibrate, a peroxisome proliferator-activated receptor alpha agonist. Materials and methods: Plasmalogens and some fatty acids in erythrocyte lysates were analyzed by GC. Peroxisomal metabolites including very long chain fatty acids as well as phytanic and pristanic acids in plasma were measured by GC-MS. Immunohistological analyses by catalase antibodies were conducted on liver sections. Results: All the conditions tested exhibited increased catalase immunoreactivity in liver sections compared to that of controls. Both calorie restriction, time-restricted feeding, as well as fenofibrate treatment exhibited lower C18:0 plasmalogen contents of erythrocyte lysates. As plasmalogens are known to be synthesized by peroxisomes, the present results suggest that the peroxisomal lipid content in membranes might be affected by conditions co-occuring with circadian perturbations. Conclusion: Shared effects of conditions associated with circadian rhythm disturbances and peroxisomal induction by fenofibrate on erythrocyte membrane lipids might indicate a link between them.
dc.identifier.doi10.31362/patd.1327736
dc.identifier.endpage98
dc.identifier.issn1309-9833
dc.identifier.issn1308-0865
dc.identifier.issue1
dc.identifier.startpage87
dc.identifier.trdizinid1219209
dc.identifier.urihttps://doi.org/10.31362/patd.1327736
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1219209
dc.identifier.urihttps://hdl.handle.net/20.500.12899/2459
dc.identifier.volume17
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofPamukkale Tıp Dergisi
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzTR-Dizin_20251023
dc.subjectBiyoloji
dc.subjectSpektroskopi
dc.subjectKimya
dc.subjectUygulamalı
dc.subjectKimya
dc.subjectOrganik
dc.subjectViroloji
dc.subjectEkoloji
dc.subjectFarmakoloji ve Eczacılık
dc.subjectKimya
dc.subjectİnorganik ve Nükleer
dc.subjectCircadian rhythm
dc.subjectplasmalogen
dc.subjectCalorie restriction
dc.subjectfenofibrate
dc.subjectperoxisome
dc.titleEffects of various conditions related to circadian rhythm disturbances on plasma and erythrocyte lipids in rats: a peroxisomal perspective
dc.typeArticle

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