The effects of agomelatine and melatonin on ECoG activity of absence epilepsy model in WAG/Rij rats

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dc.authoridAYYILDIZ, Mustafa/0000-0002-6594-3080;
dc.contributor.authorAygun, Hatice
dc.contributor.authorAydin, Duygu
dc.contributor.authorInanir, Sema
dc.contributor.authorEkici, Fatih
dc.contributor.authorAyyildiz, Mustafa
dc.contributor.authorAgar, Erdal
dc.date.accessioned2025-10-24T18:09:48Z
dc.date.available2025-10-24T18:09:48Z
dc.date.issued2015
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractThe aim of this study was to evaluate the effect of the melatonergic M1 and M2 receptor agonist and serotonergic 5-HT2C receptor antagonist agomelatine on the spike wave discharges (SWDs) seen in electrocorticographic (ECoG) recordings of WAG/Rij rats with absence epilepsy. Twenty-one WAG/Rij male rats were used in this study. Tripolar electrodes were placed on skulls and control ECoG activities were recorded. Experimental groups received normal saline (Group I: 1 mL, intraperitoneally (i.p)), agomelatine (Group II: 40 mg/kg, i.p), and melatonin (Group III: 40 mg/kg, i.p) injections for 7 days. Following this period, 2-h ECoG recordings were repeated. The number of SWDs and their durations were calculated. The total number and duration of SWDs decreased in both the agomelatine and melatonin groups. The systemic administration of agomelatine and melatonin attenuated the genetic absence epilepsy seizures in WAG/Rij rats. The repressive effect of agomelatine on the absence seizures was similar to that of the melatonin used in this study.
dc.identifier.doi10.3906/biy-1507-32
dc.identifier.endpage910
dc.identifier.issn1300-0152
dc.identifier.issn1303-6092
dc.identifier.issue6
dc.identifier.scopus2-s2.0-84946717214
dc.identifier.scopusqualityQ1
dc.identifier.startpage904
dc.identifier.trdizinid185892
dc.identifier.urihttps://doi.org/10.3906/biy-1507-32
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/185892
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3838
dc.identifier.volume39
dc.identifier.wosWOS:000365505600013
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR
dc.language.isoen
dc.publisherTubitak Scientific & Technological Research Council Turkey
dc.relation.ispartofTurkish Journal Of Biology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20251023
dc.subjectAbsence epilepsy; agomelatine; melatonin; seizure; WAG/Rij rat
dc.titleThe effects of agomelatine and melatonin on ECoG activity of absence epilepsy model in WAG/Rij rats
dc.typeArticle

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